Protein Kinase A (PKA)
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A-3 Hydrochloride
Catalog No. A13584 PKA, PKG, Casein Kinase I and II inhibitorA-3 Hydrochloride is an inhibitor of PKA (cAMP-dependent protein kinase, Ki=4.3μM) and cGMP-dependent protein kinase, Ki=3.8μM, PKC (protein kinase C, Ki=47μM), casein kinase I and II, and MLCK (myosin light chain kinase) ( Ki=7.4μM). Learn More -
PKA inhibitor fragment (6-22) amide
Catalog No. A14868 PKA inhibitorPKA inhibitor fragment (6-22) amide is a synthetic peptide that acts as a protein kinase inhibitor. Learn More -
cAMPS-Rp, triethylammonium salt
Catalog No. A16028 reversible PKA inhibitorRp-cAMPS is a cell-permeable and reversible inhibitor of PKA (protein kinase A) (Ki = 11 uM). Rp-cAMPS is resistant to hydrolysis by phosphodiesterases and is noncompetitive with respect to ATP. Learn More -
6-Bnz-cAMP sodium salt
Catalog No. A16017 PKA-selective activator6-Bnz-cAMP is a PKA-selective activator. It regulates the PKA dependent signaling pathways. Learn More -
Dibutyryl-cAMP
Catalog No. A15914 PKA activatorDibutyryl-cAMP is a cell-permeable PKA activator by mimicing the action of endogenous cAMP. Learn More -
8-Bromo-cAMP
Catalog No. A15910 protein kinase A activator8-Bromo-cAMP is a cell perbeable cyclic AMP (cAMP) analog and a PKA activator. Learn More -
Synaptamide
Catalog No. A16222 Synaptamide is a potent mediator for neurogenic differentiation of NSCs acting through PKA/CREB activation. Learn More -
CCG215022
Catalog No. A16189 GRK2/5 inhibitorCCG215022 is a potent GRK2 and GRK5 inhibitor. CCG215022 exhibited nanomolar IC50 values against both GRK2 and GRK5 and good selectivity against other closely related kinases such as GRK1 and PKA. Learn More -
cGMP Dependent Kinase Inhibitor Peptid
Catalog No. A16052 PKG/PKA inhibitorcGMP Dependent Kinase Inhibitor Peptid is a specific cGKI (cyclic GMP-dependent protein kinase) inhibitor. Data indicates that it does not block cyclic GMP-dependent protein kinase phosphorylation of intact histones and has been used to study Plasmodium falciparum. Learn More -
PKI 14-22 amide, myristoylated
Catalog No. A16031 PKA inhibitorPKI 14-22 amide, myristoylated is a useful heat stable cAMP-dependent protein kinase inhibitor. This is often used to study PKA in cellular systems in-vitro. Learn More -
KT 5720
Catalog No. A16016 PKA inhibitorKT 5720 is prepared by a modificiation of K-252a (sc-200517), which is synthesized by the fungus Nocardiopsis sp. Learn More -
A-674563
Catalog No. A11034 Akt inhibitorA-674563 is a B/Akt inhibitor with an IC50 of 14 nM and also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively. Learn More -
AT7867 2HCl
Catalog No. A15006 Akt inhibitorAT7867 dihydrochloride is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively, little activity outside the AGC kinase family. Learn More -
NH125
Catalog No. A14307 -
AT13148
Catalog No. A12464 multi-AGC kinase inhibitorAT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors. Learn More -
H 89 2HCl
Catalog No. A11935 PKA inhibitorH 89 dihydrochloride is a cell-permeable, selective, reversible, ATP-competitive and potent inhibitor of protein kinase. Learn More -
Daphnetin
Catalog No. A10286 EGFR, PKA,PKC inhibitorDaphnetin is a coumarin analog that acts as an inhibitor of several protein kinases. It inhibits EGFR kinase (IC50 = 7.67 µM), PKA (IC50 = 9.33 µM), and PKC (IC50 = 25 µM), in vitro. The inhibition of EGFR kinase by daphnetin was competitive to ATP and non-competitive to the peptide substrate. Also acts as a potent antioxidant and anti-malarial agent. Learn More