Protein Kinase A (PKA)

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  1. Dibutyryl-cAMP

    Catalog No. A15914
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    PKA activator
    Dibutyryl-cAMP is a cell-permeable PKA activator by mimicing the action of endogenous cAMP. Learn More
  2. 6-Bnz-cAMP sodium salt

    Catalog No. A16017
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    PKA-selective activator
    6-Bnz-cAMP is a PKA-selective activator. It regulates the PKA dependent signaling pathways. Learn More
  3. PKA inhibitor fragment (6-22) amide

    Catalog No. A14868
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    PKA inhibitor
    PKA inhibitor fragment (6-22) amide is a synthetic peptide that acts as a protein kinase inhibitor. Learn More
  4. cAMPS-Rp, triethylammonium salt

    Catalog No. A16028
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    reversible PKA inhibitor
    Rp-cAMPS is a cell-permeable and reversible inhibitor of PKA (protein kinase A) (Ki = 11 uM). Rp-cAMPS is resistant to hydrolysis by phosphodiesterases and is noncompetitive with respect to ATP. Learn More
  5. A-3 Hydrochloride

    Catalog No. A13584
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    PKA, PKG, Casein Kinase I and II inhibitor
    A-3 Hydrochloride is an inhibitor of PKA (cAMP-dependent protein kinase, Ki=4.3μM) and cGMP-dependent protein kinase, Ki=3.8μM, PKC (protein kinase C, Ki=47μM), casein kinase I and II, and MLCK (myosin light chain kinase) ( Ki=7.4μM). Learn More
  6. PKI 14-22 amide, myristoylated

    Catalog No. A16031
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    PKA inhibitor
    PKI 14-22 amide, myristoylated is a useful heat stable cAMP-dependent protein kinase inhibitor. This is often used to study PKA in cellular systems in-vitro. Learn More
  7. cGMP Dependent Kinase Inhibitor Peptid

    Catalog No. A16052
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    PKG/PKA inhibitor
    cGMP Dependent Kinase Inhibitor Peptid is a specific cGKI (cyclic GMP-dependent protein kinase) inhibitor. Data indicates that it does not block cyclic GMP-dependent protein kinase phosphorylation of intact histones and has been used to study Plasmodium falciparum. Learn More
  8. CCG215022

    Catalog No. A16189
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    GRK2/5 inhibitor
    CCG215022 is a potent GRK2 and GRK5 inhibitor. CCG215022 exhibited nanomolar IC50 values against both GRK2 and GRK5 and good selectivity against other closely related kinases such as GRK1 and PKA. Learn More
  9. KT 5720

    Catalog No. A16016
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    PKA inhibitor
    KT 5720 is prepared by a modificiation of K-252a (sc-200517), which is synthesized by the fungus Nocardiopsis sp. Learn More
  10. A-674563

    Catalog No. A11034
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    Akt inhibitor
    A-674563 is a B/Akt inhibitor with an IC50 of 14 nM and also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively. Learn More
  11. 8-Bromo-cAMP

    Catalog No. A15910
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    rprotein kinase A activator
    8-Bromo-cAMP is a cell perbeable cyclic AMP (cAMP) analog and a PKA activator. Learn More
  12. AT7867 2HCl

    Catalog No. A15006
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    Akt inhibitor
    AT7867 dihydrochloride is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively, little activity outside the AGC kinase family. Learn More
  13. NH125

    Catalog No. A14307
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    eEF-2 inhibitor
    NH125 is a selective eEF-2 kinase inhibitor. Learn More
  14. AT13148

    Catalog No. A12464
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    multi-AGC kinase inhibitor
    AT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors. Learn More
  15. H 89 2HCl

    Catalog No. A11935
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    PKA inhibitor
    H 89 dihydrochloride is a cell-permeable, selective, reversible, ATP-competitive and potent inhibitor of protein kinase. Learn More
  16. Daphnetin

    Catalog No. A10286
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    EGFR, PKA,PKC inhibitor
    Daphnetin is a coumarin analog that acts as an inhibitor of several protein kinases. It inhibits EGFR kinase (IC50 = 7.67 µM), PKA (IC50 = 9.33 µM), and PKC (IC50 = 25 µM), in vitro. The inhibition of EGFR kinase by daphnetin was competitive to ATP and non-competitive to the peptide substrate. Also acts as a potent antioxidant and anti-malarial agent. Learn More
  17. Synaptamide

    Catalog No. A16222
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    Synaptamide is a potent mediator for neurogenic differentiation of NSCs acting through PKA/CREB activation. Learn More

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