RNA/DNA Polymerase

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  1. Dehydroaltenusin

    Catalog No. A21804
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    eukaryotic DNA polymerase α inhibitor
    Dehydroaltenusin is a small molecule selective inhibitor of eukaryotic DNA polymerase α, a type of antibiotic produced by a fungus with an IC50 value of 0.68 μM. Learn More
  2. Mithramycin A

    Catalog No. A15385
    DNA/RNA polymerase Inhibitor
    Mithramycin A is an antibiotic DNA/RNA polymerase and DNA binding transcriptional inhibitor observed to facilitate TNF-?? and Fas-ligand induced apoptosis. Learn More
  3. Thiolutin

    Catalog No. A15386
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    RNA polymerase Inhibitor
    Thiolutin is an RNA polymerase inhibitor, and a sulfur-based microbial antibiotic generated by Streptomyces sp. Learn More
  4. Triptolide (PG490)

    Catalog No. A11596
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    Triptolide is a diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordii. Learn More
  5. ACX-362E

    Catalog No. A18560
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    DNA polymerase IIIC inhibitor
    ACX-362E is an orally available DNA polymerase IIIC (pol IIIC) inhibitor, acts as an antimicrobial agent to treat Gram-positive infections, with a MIC50 of 2 μg/mL for C. difficile. ACX-362E displays very potent in vitro and in vivo activities against broad spectrum of C. difficile pathogens. Learn More
  6. Pseudouridimycin

    Catalog No. A18520
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    RNA polymerase inhibitor
    Pseudouridimycin (PUM), an antibiotic, is a selective bacterial RNA polymerase (RNAP) inhibitor. Pseudouridimycin is a C-nucleoside analogue that is effective against both Gram-negative and Gram-positive bacteria. Learn More
  7. DNA31

    Catalog No. A18466
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    RNA polymerase inhibitor
    DNA31 is a potent RNA polymerase inhibitor. Learn More
  8. ddATP

    Catalog No. A18898
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    DNA polymerase inhibitor
    dATP is a dideoxynucleotide, acts as a chain-elongating inhibitor of DNA polymerase, used for Sanger method for DNA sequencing. Learn More
  9. dmDNA31

    Catalog No. A18469
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    DNA-dependent RNA polymerase inhibitor
    dmDNA31 is a rifamycin-class antibiotic that inhibits bacterial DNA-dependent RNA polymerase with potent bactericidal activity against S. aureus. Learn More
  10. Oncrasin 1

    Catalog No. A15333
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    RNA polymerase II inhibitor
    Oncrasin 1 is a proapoptotic substance. Induces abnormal nuclear aggregation of PKCι and suppressing RNA transcription. Learn More
  11. Valaciclovir

    Catalog No. A15270
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    DNA polymerase Inhibitor
    Valacyclovir is an antiviral drug used in the management of herpes simplex, herpes zoster, and herpes B. Learn More
  12. BMH-21

    Catalog No. A14335
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    RNA polymerase inhibitor
    BMH-21 is a potent small molecule DNA intercalator. BMH-21 binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription. Learn More
  13. Abacavir sulfate

    Catalog No. A11120
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    Transcriptase inhibitor
    Abacavir sulfate is a nucleoside analog reverse transcriptase inhibitor (NRTI); guanosine analog used to treat HIV and AIDS. Learn More
  14. Abacavir

    Catalog No. A11115
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    Transcriptase inhibitor
    Abacavir is a nucleoside analog reverse transcriptase inhibitor (NRTI); guanosine analog used to treat HIV and AIDS. Learn More
  15. Fludarabine Phosphate (Fludara)

    Catalog No. A10395
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    Fludarabine or fludarabine phosphate (Fludara) is a chemotherapy drug used in the treatment of hematological malignancies (cancers of blood cells such as leukemias and lymphomas) .Fludarabine inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase. It is active against both dividing and resting cells. Learn More
  16. Rifabutin

    Catalog No. A10790
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    RNA polymerase inhibitor
    Rifabutin is a bactericidal antibiotic drug primarily used in the treatment of tuberculosis. Its effect is based on blocking the DNA-dependent RNA-polymerase of the bacteria. Learn More
  17. Rifampin

    Catalog No. A10791
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    RNA polymerase inhibitor
    Antibiotic; inhibits bacterial RNA polymerase. Prototypical activator of the pregnane X receptor (PXR). Learn More
  18. T-705 (Favipiravir)

    Catalog No. A11590
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    viral RNA polymerase inhibitor

    T-705, a substituted pyrazine compound, has been found to exhibit potent anti-influenza virus activity in vitro and in vivo.

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  19. Actinomycin D

    Catalog No. A13239
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    Actinomycin D is a metabolite isolated from Streptomyces parvulus that binds to the GpC steps of DNA. The compound acts as an antibiotic and is more effective against gram-positive bacteria than gram negative bacteria. Learn More
  20. Delavirdine mesylate

    Catalog No. A13274
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    NNRT inhibitor
    Delavirdine is a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). Learn More
  21. Tenofovir (Viread)

    Catalog No. A10908
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    HIV reverse transcriptase inhibitor
    Tenofovir is in a class of medications called nucleoside reverse transcriptase inhibitors (NRTIs). It works by decreasing the amount of HIV in the blood. Learn More

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