ROR

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  1. SR1078

    Catalog No. A15245
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    ROR agonist
    SR1078 is an agonist of retinoic acid receptor-related orphan receptors (ROR) RORα/γ; increases transcription of RORα target genes; thought to increase p53 stability. Learn More
  2. SR3335

    Catalog No. A15246
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    RORα agonist
    SR3335 is a selective RORα synthetic ligand, directly binds to RORα, but not other RORs, and functions as a selective partial inverse agonist of RORα in cell-based assays. Learn More
  3. SR1001

    Catalog No. A13193
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    ROR agonist
    SR1001 is a selective ROR-alpha and ROR-gamma inverse agonist; suppresses TH17 cell differentiation and inhibits autoimmunity. Learn More
  4. ROR gamma modulator 1

    Catalog No. A16291
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    RORγ modulator
    RORγ modulator 1 is a retinoid-related orphan receptor gamma (RORy) modulator, extracted from patent WO/2015061515 A1, example 124. Learn More
  5. SR-2211

    Catalog No. A13568
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    RORr agonist
    SR-2211 selectively binds RORr(Ki = 105 nM), acting as an inverse agonist of constitutive in vitro RORr activity (IC50 = 320 nM). Learn More
  6. A-9758

    Catalog No. A19078
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    RORγt inverse agonist
    A-9758 is a RORγ ligand and a potent, selective RORγt inverse agonist (IC50=5 nM), and exhibits robust potency against IL-17A release. Learn More
  7. S18-000003

    Catalog No. A19105
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    RORγt inhibitor
    S18-000003 is a potent orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t (RORγt) inhibitor with an IC50 of 29 nM. S18-000003 inhibits IL-17 production. Learn More
  8. XY101

    Catalog No. A18437
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    RORγ inverse agonist
    XY101 is a potent, selective, metabolically stable and orally available RORγ inverse agonist with an IC50 of 30 nM and a Kd of 380 nM. Learn More
  9. AZD-0284

    Catalog No. A18766
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    RORγ agonist
    AZD-0284 is a potent, selective, inverse agonist of the nuclear receptor RORγ for the potential treatment of Plaque psoriasis. Learn More
  10. Cintirorgon (LYC-55716)

    Catalog No. A16863
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    RORγ agonist
    LYC-55716 is novel oral RAR-related orphan receptor γ (RORγ) agonist. Learn More
  11. AGN-242428

    Catalog No. A16935
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    RORγt inhibitor
    AGN-242428, also known as VTP-43742, is a potent, selective and orally active RORγt inhibitor for the treatment of autoimmune disorders, including multiple sclerosis and psoriasis. Learn More
  12. ROR agonist-1

    Catalog No. A18569
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    ROR agonist
    ROR agonist-1 is a potent and orally bioavailable inverse agonist of the retinoic acid receptor-related orphan receptor C2 (RORC2), inhibition of IL-17A production from human primary TH 17 cells with a pIC50 of 7.5. Learn More

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