Hedgehog

16 Item(s)

per page

Set Descending Direction
  1. Mebendazole

    Catalog No. A16606
    Quick View
    Hedgehog inhibitor
    Mebendazole is a highly effective, broad-spectrum antihelmintic indicated for the treatment of nematode infestations; has been found as a hedgehog inhibitor. Learn More
  2. U18666A

    Catalog No. A20195
    Quick View
    cholesterol synthesis/Hedgehog inhibitor
    U18666A, a cell permeable drug, is a cholesterol synthesis and transport inhibitor. Learn More
  3. Purmorphamine

    Catalog No. A11480
    Quick View
    Hedgehog signaling activator
    Purmorphamine is a 2,6,9-trisubstituted purine that promotes the differentiation of both human and mouse mesenchymal progenitor cells into osteoblasts. Learn More
  4. HPI-4

    Catalog No. A16349
    Quick View
    hedgehog inhibitor
    HPI-4 is a hedgehog (Hh) signaling pathway inhibitor with median inhibitory concentration (IC50) less than 10 μM. Learn More
  5. RU-SKI 43

    Catalog No. A16229
    Quick View
    Hhat inhibitor
    RU-SKI 43 is a small molecule inhibitor of Hhat(Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh. Learn More
  6. MK-4101

    Catalog No. A16111
    Quick View
    Hedgehog inhibitor
    MK-4101 is a potent and selective inhibitor of the Hedgehog Pathway. Learn More
  7. HhAntag

    Catalog No. A12418
    Quick View
    HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway. Learn More
  8. JK 184

    Catalog No. A12925
    Quick View
    Hedgehog inhibitor
    JK184 is potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM). Learn More
  9. Hh-Ag1.5

    Catalog No. A12920
    Quick View
    Hedgehog inhibitor
    Hh-Ag1.5 is one of the most potent and selective small-molecule agonists of the Hedgehog pathway, targeting Smoothened (Smo) with an EC50 ~1 nM. Learn More
  10. GANT 58

    Catalog No. A11442
    Quick View
    GLI antagonist
    GANT 58 is a potent Gli antagonist that inhibits GLI1-induced transcription with IC50 of 5 μM. Learn More
  11. GANT61

    Catalog No. A13252
    Quick View
    GLI antagonist
    GANT61 is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog with IC50 of 5 μM, displays selectivity over other pathways, such as TNF and glucocorticoid receptor gene transactivation. Learn More
  12. SANT-1

    Catalog No. A13095
    Quick View
    Sonic hedgehog inhibitor
    SANT-1 is a potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (KD = 1.2 nM). Inhibits smoothened agonist effects with an IC50 of 20 nM (in Shh-LIGHT2 cells). Learn More
  13. TAK-441

    Catalog No. A11351
    Quick View
    Hedgehog inhibitor
    TAK-441 is a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor. Learn More
  14. LY2940680 (Taladegib)

    Catalog No. A11048
    Quick View
    SMO Antagonist
    LY2940680 has been shown to affect a cancer cell signaling pathway initiated by the Hedgehog (Hh) protein. Learn More
  15. Cyclopamine

    Catalog No. A10249
    Quick View
    Hedgehog signaling inhibitor
    Cyclopamine is a Smo or hedgehog signaling pathway inhibitor. Learn More
  16. GDC-0449 (Vismodegib)

    Catalog No. A10258
    Quick View
    Hedgehog antagonist
    GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM. Learn More

16 Item(s)

per page

Set Descending Direction
Rewards