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Hedgehog

Catalog No.	Product Name	Application	Product Information
A10258 SALE	GDC-0449 (Vismodegib)	Hedgehog antagonist	GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM. Product Citations (2) Yi Yang, .et al. Tumidulin, a Lichen Secondary Metabolite, Decreases the Stemness Potential of Colorectal Cancer Cells, Molecules, 2018, Nov; 23(11): 2968 PMID: 30441806 Olesen UH, .et al. Topical delivery of vismodegib using ablative fractional laser and micro-emulsion formulation in vitro, Lasers Surg Med, 2018, Aug 28 PMID: 30152536
A16229	RU-SKI 43	Hhat inhibitor	RU-SKI 43 is a small molecule inhibitor of Hhat(Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh.
A16111	MK-4101	Hedgehog inhibitor	MK-4101 is a potent and selective inhibitor of the Hedgehog Pathway.
A12418	HhAntag	-	HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway.
A12920	Hh-Ag1.5	Hedgehog inhibitor	Hh-Ag1.5 is one of the most potent and selective small-molecule agonists of the Hedgehog pathway, targeting Smoothened (Smo) with an EC50 ~1 nM.
A11442	GANT 58	GLI antagonist	GANT 58 is a potent Gli antagonist that inhibits GLI1-induced transcription with IC50 of 5 μM.
A13252 SALE	GANT61	GLI antagonist	GANT61 is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog with IC50 of 5 μM, displays selectivity over other pathways, such as TNF and glucocorticoid receptor gene transactivation. Product Citations (1) Hui Liang, .et al. Targeting the PI3K/AKT pathway via GLI1 inhibition enhanced the drug sensitivity of acute myeloid leukemia cells, Sci Rep, 2017, 7: 40361 PMID: 28098170
A13095 SALE	SANT-1	Sonic hedgehog inhibitor	SANT-1 is a potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (KD = 1.2 nM). Inhibits smoothened agonist effects with an IC50 of 20 nM (in Shh-LIGHT2 cells).
A11351	TAK-441	Hedgehog inhibitor	TAK-441 is a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor.
A11048 SALE	LY2940680 (Taladegib)	SMO Antagonist	LY2940680 has been shown to affect a cancer cell signaling pathway initiated by the Hedgehog (Hh) protein.
A10249	Cyclopamine	Hedgehog signaling inhibitor	Cyclopamine is a Smo or hedgehog signaling pathway inhibitor.
A16349	HPI-4	hedgehog inhibitor	HPI-4 is a hedgehog (Hh) signaling pathway inhibitor with median inhibitory concentration (IC50) less than 10 μM.

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