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Mebendazole
Catalog No. A16606 Hedgehog inhibitorMebendazole is a highly effective, broad-spectrum antihelmintic indicated for the treatment of nematode infestations; has been found as a hedgehog inhibitor. Learn More -
U18666A
Catalog No. A20195 cholesterol synthesis/Hedgehog inhibitorU18666A, a cell permeable drug, is a cholesterol synthesis and transport inhibitor. Learn More -
Purmorphamine
Catalog No. A11480 Hedgehog signaling activatorPurmorphamine is a 2,6,9-trisubstituted purine that promotes the differentiation of both human and mouse mesenchymal progenitor cells into osteoblasts. Learn More -
HPI-4
Catalog No. A16349 hedgehog inhibitorHPI-4 is a hedgehog (Hh) signaling pathway inhibitor with median inhibitory concentration (IC50) less than 10 μM. Learn More -
RU-SKI 43
Catalog No. A16229 Hhat inhibitorRU-SKI 43 is a small molecule inhibitor of Hhat(Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh. Learn More -
MK-4101
Catalog No. A16111 Hedgehog inhibitorMK-4101 is a potent and selective inhibitor of the Hedgehog Pathway. Learn More -
HhAntag
Catalog No. A12418 HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway. Learn More -
JK 184
Catalog No. A12925 Hedgehog inhibitorJK184 is potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM). Learn More -
Hh-Ag1.5
Catalog No. A12920 Hedgehog inhibitorHh-Ag1.5 is one of the most potent and selective small-molecule agonists of the Hedgehog pathway, targeting Smoothened (Smo) with an EC50 ~1 nM. Learn More -
GANT 58
Catalog No. A11442 GLI antagonistGANT 58 is a potent Gli antagonist that inhibits GLI1-induced transcription with IC50 of 5 μM. Learn More -
GANT61
Catalog No. A13252 GLI antagonistGANT61 is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog with IC50 of 5 μM, displays selectivity over other pathways, such as TNF and glucocorticoid receptor gene transactivation. Learn More -
SANT-1
Catalog No. A13095 Sonic hedgehog inhibitorSANT-1 is a potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (KD = 1.2 nM). Inhibits smoothened agonist effects with an IC50 of 20 nM (in Shh-LIGHT2 cells). Learn More -
TAK-441
Catalog No. A11351 Hedgehog inhibitorTAK-441 is a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor. Learn More -
LY2940680 (Taladegib)
Catalog No. A11048 SMO AntagonistLY2940680 has been shown to affect a cancer cell signaling pathway initiated by the Hedgehog (Hh) protein. Learn More -
Cyclopamine
Catalog No. A10249 Hedgehog signaling inhibitorCyclopamine is a Smo or hedgehog signaling pathway inhibitor. Learn More -
GDC-0449 (Vismodegib)
Catalog No. A10258 Hedgehog antagonistGDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM. Learn More
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