Hedgehog

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  1. Purmorphamine

    Catalog No. A11480
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    Hedgehog signaling activator
    Purmorphamine is a 2,6,9-trisubstituted purine that promotes the differentiation of both human and mouse mesenchymal progenitor cells into osteoblasts. Learn More
  2. U18666A

    Catalog No. A20195
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    cholesterol synthesis/Hedgehog inhibitor
    U18666A, a cell permeable drug, is a cholesterol synthesis and transport inhibitor. Learn More
  3. Mebendazole

    Catalog No. A16606
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    Hedgehog inhibitor
    Mebendazole is a highly effective, broad-spectrum antihelmintic indicated for the treatment of nematode infestations; has been found as a hedgehog inhibitor. Learn More
  4. GDC-0449 (Vismodegib)

    Catalog No. A10258
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    Hedgehog antagonist
    GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM. Learn More
  5. Cyclopamine

    Catalog No. A10249
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    Hedgehog signaling inhibitor
    Cyclopamine is a Smo or hedgehog signaling pathway inhibitor. Learn More
  6. LY2940680 (Taladegib)

    Catalog No. A11048
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    SMO Antagonist
    LY2940680 has been shown to affect a cancer cell signaling pathway initiated by the Hedgehog (Hh) protein. Learn More
  7. TAK-441

    Catalog No. A11351
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    Hedgehog inhibitor
    TAK-441 is a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor. Learn More
  8. SANT-1

    Catalog No. A13095
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    Sonic hedgehog inhibitor
    SANT-1 is a potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (KD = 1.2 nM). Inhibits smoothened agonist effects with an IC50 of 20 nM (in Shh-LIGHT2 cells). Learn More
  9. GANT61

    Catalog No. A13252
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    GLI antagonist
    GANT61 is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog with IC50 of 5 μM, displays selectivity over other pathways, such as TNF and glucocorticoid receptor gene transactivation. Learn More
  10. GANT 58

    Catalog No. A11442
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    GLI antagonist
    GANT 58 is a potent Gli antagonist that inhibits GLI1-induced transcription with IC50 of 5 μM. Learn More
  11. Hh-Ag1.5

    Catalog No. A12920
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    Hedgehog inhibitor
    Hh-Ag1.5 is one of the most potent and selective small-molecule agonists of the Hedgehog pathway, targeting Smoothened (Smo) with an EC50 ~1 nM. Learn More
  12. JK 184

    Catalog No. A12925
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    Hedgehog inhibitor
    JK184 is potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM). Learn More
  13. HhAntag

    Catalog No. A12418
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    HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway. Learn More
  14. MK-4101

    Catalog No. A16111
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    Hedgehog inhibitor
    MK-4101 is a potent and selective inhibitor of the Hedgehog Pathway. Learn More
  15. RU-SKI 43

    Catalog No. A16229
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    Hhat inhibitor
    RU-SKI 43 is a small molecule inhibitor of Hhat(Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh. Learn More
  16. HPI-4

    Catalog No. A16349
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    hedgehog inhibitor
    HPI-4 is a hedgehog (Hh) signaling pathway inhibitor with median inhibitory concentration (IC50) less than 10 μM. Learn More

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