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Hedgehog
Catalog No. | Product Name | Application | Product Information |
---|---|---|---|
A10258 SALE |
GDC-0449 (Vismodegib) |
Hedgehog antagonist |
GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM.
|
A16229 |
RU-SKI 43 |
Hhat inhibitor |
RU-SKI 43 is a small molecule inhibitor of Hhat(Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh.
|
A16111 |
MK-4101 |
Hedgehog inhibitor |
MK-4101 is a potent and selective inhibitor of the Hedgehog Pathway.
|
A12418 |
HhAntag |
- |
HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway.
|
A12920 |
Hh-Ag1.5 |
Hedgehog inhibitor |
Hh-Ag1.5 is one of the most potent and selective small-molecule agonists of the Hedgehog pathway, targeting Smoothened (Smo) with an EC50 ~1 nM.
|
A11442 |
GANT 58 |
GLI antagonist |
|
A13252 SALE |
GANT61 |
GLI antagonist |
GANT61 is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog with IC50 of 5 μM, displays selectivity over other pathways, such as TNF and glucocorticoid receptor gene transactivation.
|
A13095 SALE |
SANT-1 |
Sonic hedgehog inhibitor |
SANT-1 is a potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (KD = 1.2 nM). Inhibits smoothened agonist effects with an IC50 of 20 nM (in Shh-LIGHT2 cells).
|
A11351 |
TAK-441 |
Hedgehog inhibitor |
TAK-441 is a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor.
|
A11048 SALE |
LY2940680 (Taladegib) |
SMO Antagonist |
LY2940680 has been shown to affect a cancer cell signaling pathway initiated by the Hedgehog (Hh) protein.
|
A10249 |
Cyclopamine |
Hedgehog signaling inhibitor |
Cyclopamine is a Smo or hedgehog signaling pathway inhibitor.
|
A16349 |
HPI-4 |
hedgehog inhibitor |
HPI-4 is a hedgehog (Hh) signaling pathway inhibitor with median inhibitory concentration (IC50) less than 10 μM.
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