P2X Receptor

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  1. Minodronic acid

    Catalog No. A21975
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    purinergic P2X2/3 receptors antagonist
    Minodronic acid (YM-529) is an antagonist of purinergic P2X2/3 receptors involved in pain. Learn More
  2. GW791343 trihydrochloride

    Catalog No. A21204
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    P2X7 allosteric modulator
    GW791343 3Hcl is a P2X7 allosteric modulator; exhibits species-specific activity and acts as a negative allosteric modulator of human P2X7 (pIC50 = 6.9 - 7.2). Learn More
  3. CE-224535

    Catalog No. A21183
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    P2X7 receptor antagonist
    CE-224535 is a selective P2X7 receptor antagonist. Learn More
  4. A 839977

    Catalog No. A21178
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    P2X7 selective antagonist
    A 839977 is a P2X7 selective antagonist. Learn More
  5. JNJ-54175446

    Catalog No. A18675
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    P2X7 receptor antagonist
    JNJ-54175446 is a potent and selective brain penetrant P2X7 receptor antagonist, with pIC50s of 8.46 and 8.81 for hP2X7 receptor and rP2X7 receptor, respectively. Learn More
  6. A 438079 hydrochloride

    Catalog No. A14983
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    P2X7 receptor antagonist
    A 438079 Hcl is a competitive P2X7 receptor antagonist (pIC50 = 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line). Learn More
  7. AF-353

    Catalog No. A13131
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    P2X3/P2X2/3 receptor antagonist
    AF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist, inhibits human and rat P2X3 (pIC50= 8.0). Learn More
  8. A-438079 HCl

    Catalog No. A12597
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    P2X7 receptor antagonist
    A-438079 HCl is a competitive P2X7 receptor antagonist (pIC50 = 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line). Devoid of activity at other P2 receptors (IC50 >> 10 uM). Learn More
  9. A-804598

    Catalog No. A16066
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    P2X7 receptor antagonist
    A-804598 is a P2X7 selective, competitive antagonist with the IC50s value for human, rat and mouse channels of 11, 10 and 9 nM, respectively. Learn More
  10. A-317491 sodium salt hydrate

    Catalog No. A12412
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    P2X3 and P2X2/3 receptor antagonist
    A-317491 sodium salt hydrate is a non-nucleotide P2X3 and P2X2/3 receptor antagonist, which inhibits calcium flux mediated by the receptors. Learn More
  11. NF 279

    Catalog No. A11972
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    P2X1 antagonist
    NF279 is a suramin analog that acts as a highly selective, competitive, and reversible ATP-antagonist of P2X receptor (IC50/KB ~ 1 μM in smooth muscle). Learn More
  12. A 740003

    Catalog No. A11316
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    P2X7 receptor antagonist
    A 740003 is a novel competitive antagonist of P2X7 receptors (IC50 values = 40 nM for human and 18 nM for rat). Learn More
  13. Ticlopidine HCl

    Catalog No. A11690
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    Ticlopidine is an adenosine diphosphate (ADP) receptor inhibitor. It inhibits platelet aggregation by altering the function of platelet membranes by blocking ADP receptors. This prevents the conformational change of glycoprotein IIb/IIIa which allows platelet binding to fibrinogen. Learn More
  14. GW791343 HCl

    Catalog No. A11107
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    P2X7 modulator
    GW791343 HCl acts as a negative allosteric modulator of human P2X7 (pIC50 = 6.9 - 7.2) and a positive allosteric modulator of rat P2X7. Learn More

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