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Catalog No.
Product Name
Application
Product Information
Product Citation
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Cathepsin K Inhibitor
Odanacatib is an inhibitor of cathepsin K,an enzyme involved in bone resorption. -
Cathepsin B inhibitor
CA-074 is a potent inhibitor of cathepsin B with a Ki of 2 to 5 nM.- Tianming Qiu, .et al. , Cell Death Dis, 2018, Oct; 9(10): 946 PMID: 30237538
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Cysteine Protease inhibitor
Loxistatin Acid, a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor. -
Cysteine Protease inhibitor
E-64d is an inhibitor of cathepsins B and L and it is lysosome and cell permeable.- Jason J McDougall, .et al. , Mol Pain, 2021, 17 PMID: 34006144
- Paudel DB, .et al. , Virology, 2018, Nov;524:127-139 PMID: 30195250
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cathepsin C substrate
Gly-Phe-beta-naphthylamide is a cathepsin C substrate. The compound is described to accumulate inside lysosomes leading to their destruction. -
Cysteine Protease inhibitor
Leupeptin hemisulfate is a reversible inhibitor of trypsin-like and cysteine proteases such as calpain. -
Calpain Inhibitor
Calpain Inhibitor II, ALLM is a cell-permeable inhibitor of calpain I, calpain II, cathepsin L and cathepsin B with Ki values of 120 nM, 230 nM, 0.6 nM and 100 nM, respectively. -
Calpain Inhibitor III
MDL 28170 is a cell permeable selective inhibitor of Calpain 1, a Ca2+-dependent cysteine protease which has been implicated in apoptosis of immune cells as well as neuronal cells.- Barker BS, .et al. , Neuroscience, 2019, Nov 26. pii: S0306-4522(19)30796-1 PMID: 31783100
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Non-peptide calpain inhibitor
PD 150606 is a cell-permeable, non-competitive, selective, non-peptide Ca2+ dependent calpain inhibitor for calpain-1 and for calpain-2 directed towards the Ca2+ binding sites of calpain.- Hisamatsu Y, .et al. , Bioconjug Chem, 2017, Feb 15;28(2):507-523 PMID: 28032992
- Z-Gly-Pro-Arg-AMC hydrochloride a fluorescent trypsin and cathepsin K substrate. Z-Gly-Pro-Arg-AMC hydrochloride can be used to determine trypsin and cathepsin K activity.
