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Membrane Transporters-Ion Channels
Membrane Transporters-Ion Channels
Catalog No.
Product Name
Application
Product Information
Product Citation
Kir6 (KATP) channel opener
Nicorandil (SG-75) is potassium channel activator.
VX-770 (Ivacaftor) is known as a CFTR potentiator.
2 publications
Daichi Hinata, .et al. , Int J Mol Sci , 2023, Jan 24;24(3):2305 PMID: 36768629 Okiyoneda T, .et al. , Dev Cell , 2018, Mar 26;44(6):694-708.e7 PMID: 29503157
CK-1827452 is a selective cardiac specific myosin activator.
11 publications
Oleg Lookin, .et al. , Clin Exp Pharmacol Physiol , 2021, Aug 29 PMID: 34459025 Gabor A. Fulop, .et al. , Basic Res Cardiol , 2021, 116(1): 24 PMID: 33844095 Wanjian Tang, .et al. , J Biol Chem , 2019, October 2 PMID: 31578282 Thinh T. Kieu, .et al. , Biophysical Journal , 2019, 2019 PMID: 31103235 Alexandre J. S. Ribeiro, .et al. , Circ Res , 2017, May 12; 120(10): 1572-1583 PMID: 28400398 Anja M. Swenson, .et al. , J Biol Chem , 2017, Mar 3; 292(9): 3768-3778 PMID: 28082673 Nánási P Jr, .et al. , Eur J Pharmacol , 2017, Aug 15;809:73-79 PMID: 28506910 Horváth B, .et al. , Naunyn Schmiedebergs Arch Pharmacol , 2017, Dec;390(12):1239-1246 PMID: 28940010 Szentandrassy N, .et al. , J Physiol Pharmacol , 2016, Aug;67(4):483-489 PMID: 27779469 L Nagy, .et al. , Br J Pharmacol , 2015, Sep; 172(18): 4506-4518 PMID: 26140433 Larissa Butler, .et al. , Toxicol Sci , 2015, Jun;145(2):396-406 PMID: 25820236
NS 309 is a positive modulator of small- and intermediate- conductance Ca2+-activated K+ channels (KCa2 and KCa3.1 channels).
OAC1 enhances iPSC reprogramming efficiency by enhancing Oct4 and Nanog driven gene expression.
photoactive TRPA1 activator
Optovin is a reversible photoactive TRPA1 activator.
TRPM8 and TRPA1 activator
Icilin is a cooling agent that activates the novel cold receptors TRPM8 (CMR1) and TRPA1 (ANKTM1/TRPN1), members of the TRP ion channel family. Induces currents in CMR1-expressing HEK 293 cells (EC50 = 0.36 μM)
GSK1016790A is a novel, potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34nM in choroid plexus epithelial cells.
Potassium channel activator
NS1619 is a Bkca opener or large-conductance Ca2+-activated potassium (BKCa, KCa1.1) channel activator.
Eact activates the Calcium-activated Chloride channel (CaCC) TMEM16A CaCC.
SERCA2 allosteric activator
CDN1163 is a SERCA2 allosteric activator. It increases Ca2+-ATPase activity and Ca2+ uptake by ER microsomes from obese mice. Rescues HEK cells from ER stress-induced cell death.
potassium channel activator
SKA-31 is an activator of KCa2 and KCa3.1 calcium-activated potassium channels.
Potassium Channel activator
Pinacidil monohydrate, an antihypertensive drug, is a potassium channel activator.
CLP290 is an orally available activator of the neuron-specific K+-Cl? cotransporter KCC2, displays potential for treatment of a wide range of neurological and psychiatric indications.
P-1075 is a potent activator of sulfonylurea receptor 2-associated ATP-sensitive potassium channels (SUR2-KIR6), with an EC50 value of 45 nM for SUR2B-KIR6 channel activation.
Kv7.2/Kv7.4 channels activator
ML213 is a selective activator of Kv7.2 and Kv7.4 channels, enhances Kv7.2 and Kv7.4 channels with EC50s of 230 and 510 nM, respectively.
SKA-121 is a selective KCa3.1 activator. SKA-121 exhibits EC50s of 109 nM and 4.4 μM for KCa3.1 and KCa2.3, respectively.
KCNQ2/Q3 potassium channel activator
ICA-069673 is a KCNQ2/Q3 potassium channel activator with an IC50 of 0.69 μM.
KCNQ1 potassium channel activator
ML277(CID53347902) is a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator with EC50 of 270 nM.
Periplocin is a cardiotonic steroid isolated from Periploca forrestii. Periplocin promotes tumor cell apoptosis and inhibits tumor growth. Periplocin has the potential to facilitate wound healing through the activation of Src/ERK and
PI3K /Akt pathways mediated by Na/K-ATPase.
Ca2+-activated K+ channel activator
NS19504 is a Ca2+-activated K+ channel (BK channel, KCa1.1 channel) activator (EC50=11.0 μM) with relaxing effect on bladder smooth muscle spontaneous phasic contractions.
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