Shop By
Catalog No.
Product Name
Application
Product Information
Product Citation
-
DUB/Bcr/ABL Inhibitor
WP1130 (Degrasyn) is a novel selective small molecular deubiquitinase inhibitor and a Bcr/Abl destruction pathway activator that specifically and rapidly down-regulates both wild-type and mutant Bcr/Abl protein without affecting bcr/abl gene expression in chronic myelogenous leukemia (CML) cells.- Kevin Bohm, .et al. , Arch Pharm (Weinheim), 2023, Jul;356(7):e2200661 PMID: 37196427
-
DUB inhibitor
PR-619 is a cell-permeable, reversible, and broad-spectrum inhibitor of the deubiquitinylating enzymes (DUBs).- Anurag Rathore, .et al. , Sci Rep, 2020, 10: 5350 PMID: 32210344
-
Usp14 inhibitor
IU1 is a selective inhibitor of Usp14. It inhibits the catalytic activity of proteasome-associated Usp14 in vitro (IC50 < 4 uM).- Kevin Bohm, .et al. , Arch Pharm (Weinheim), 2023, Jul;356(7):e2200661 PMID: 37196427
- Anurag Rathore, .et al. , Sci Rep, 2020, 10: 5350 PMID: 32210344
-
DUB inhibitor
NSC 687852 is an inhibitor of ubiquitin-specific-processing protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5), two proteasome-associated DUBs.- Anurag Rathore, .et al. , Sci Rep, 2020, 10: 5350 PMID: 32210344
-
USP2 inhibitor
ML364 is a selective ubiquitin specific peptidase 2 (USP2) inhibitor (IC50=1.1 μM) with anti-proliferative activity.- Kevin Bohm, .et al. , Arch Pharm (Weinheim), 2023, Jul;356(7):e2200661 PMID: 37196427