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$0.00 Casein Kinase
| Catalog No. | Inhibitor Name | CK1 | CK2 | Other |
|---|---|---|---|---|
| A11060 | Silmitasertib | *** | ||
| A13949 | D 4476 | ** | ALK5 | |
| A16235 | SR-3029 | ** | ||
| A15764 | IC 261 | * | ||
| A15257 | TBB | * | ||
| A15069 | DMAT | ** | ||
| A16236 | TA-01 | *** | p38α | |
| A14101 | TTP-22 | ** | JNK3, ROCK1, and MET | |
| A13574 | LH 846 | ** | ||
| A11781 | PF 670462 | *** | ||
| A13977 | TMCB | ** | ERK8 |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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CX-4945 (Silmitasertib)
Catalog No. A11060 CK2 inhibitorCX-4945 is a potent and selective orally bioavailable small molecule inhibitor of CK2 that inhibits human umbilical vein endothelial cell migration, tube formation, and blocks CK2-dependent hypoxia-induced factor 1 alpha (HIF-1α) transcription in cancer cells. Learn More -
LH 846
Catalog No. A13574 CK1 inhibitorLH 846 is a selective inhibitor of casein kinase (CK) 1δ (IC50 values are 290 nM, 1.3 μM and 2.5 μM for CK1δ, ε and α) Learn More -
D4476
Catalog No. A13949 CK1 InhibitorD4476 is a cell-permeant inhibitor of casein kinase 1. Learn More -
TTP-22
Catalog No. A14101 CK2 inhibitorTTP 22 is a high affinity, casein kinase 2 (CK2) inhibitor (IC50= 0.1uM, Ki= 40nM). In addition, TTP 22 shows selectivity for CK2 over JNK3, ROCK1, and MET (inhibitory effects displayed at greater than 10 uM). TTP 22 is highly conserved serine/threonine protein kinase that is also involved in cell proliferation, cell differentiation and apoptosis. Learn More -
DMAT
Catalog No. A15069 CK2 inhibitorDMAT is a potent and specific CK2 inhibitor with an IC50 of 0.13 uM. Learn More -
TBB
Catalog No. A15257 CK2 InhibitorTBB is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2)with IC50s of 0.9 and 1.6 uM for rat liver and human recombinant CK2 respectively). Learn More -
IC 261
Catalog No. A15764 -
CX-4945 sodium salt
Catalog No. A16234 CK2 inhibitorCX-4945 sodium salt is a potent and selective ATP-competitive small molecule protein kinase CK2 inhibitor with a Ki and an IC50 of 0.38 and 1 nM for recombinant human CK2α, respectively. Learn More -
SR-3029
Catalog No. A16235 CK1δ/CK1ε inhibitorSR-3029 is a potent and highly specific CK1δ/CK1ε inhibitor with the IC50 of 97 nM. Learn More -
TA-01
Catalog No. A16236 CK inhibitorTA-01 potently inhibits CK1ε, CK1δ,and p38α (IC50values are 6.4, 6.8, and 6.7 nM respectively). Learn More -
PF 670462
Catalog No. A11781 Casein kinase inhibitorPotent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor (IC50 values are 7.7 and 14 nM respectively) that displays > 30-fold selectivity over 42 other common kinases. Inhibits PER protein nuclear translocation (EC50 = 290 nM) causing phase shifts in circadian rhythms and attenuates methamphetamine-stimulated locomotion in vivo. Learn More -
Ellagic acid
Catalog No. A10344 Ellagic acid is a natural phenol antioxidant found in numerous fruits and vegetables. The antiproliferative and antioxidant properties of ellagic acid have spurred preliminary research into the potential health benefits of ellagic acid consumption. Learn More -
A-3 Hydrochloride
Catalog No. A13584 PKA, PKG, Casein Kinase I and II inhibitorA-3 Hydrochloride is an inhibitor of PKA (cAMP-dependent protein kinase, Ki=4.3μM) and cGMP-dependent protein kinase, Ki=3.8μM, PKC (protein kinase C, Ki=47μM), casein kinase I and II, and MLCK (myosin light chain kinase) ( Ki=7.4μM). Learn More -
TMCB
Catalog No. A13977 CK2/ERK8 inhibitorMCB has been shown to inhibit both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8/MAPK15) (IC50 = 0.50 uM for both CK2 and ERK8). Learn More
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