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Inhibitory Selectivity
Catalog No.Inhibitor Name Kinesin
A11170AZ 3146
A14234ARQ 621

1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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Catalog No. Product Name Application Product Information

Arry-520 (Filanesib)

KSP inhibitor
KSP inhibitor ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5) with potential antineoplastic activity.
A15844 SALE

K 858

Kinesin Eg5 inhibitor
K 858 is a selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor with IC50 value of 1.3 uM.
A15841 SALE


Kinesin Eg5 inhibitor
Dimethylenastron is an inhibitor of mitotic motor kinesin Eg5 with IC50 value of 200 nM.

ARRY-520 R enantiomer

KSP inhibitor
ARRY-520 R enantiomer is the R form of ARRY-520, which is a synthetic, small molecule kinesin spindle protein (KSP) inhibitor with IC50 of 6 nM.


Mps1 inhibitor
MPI-0479605 is an ATP competitive and selective inhibitor of mitotic kinase Mps1

ARQ 621

Eg5 mitotic motor protein inhibitor
ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor.


Microtubule Associated inhibitor
CW069 is an allosteric, and selective inhibitor of microtubule motor protein HSET with IC50 of 75 uM, significant selectivity over KSP.
A11435 SALE


CENP-E inhibitor
GSK-923295, is a small-molecule inhibitor of the mitotic kinesin centromere-associated protein E, (CENP-E).


Kinesin-5(KIF11) inhibitor
Monastrol is a potent, cell permeable non-tubulin-interacting mitosis inhibitor. Monastrol blocks mitosis (IC5N/A = 14 ?M) by binding to the mitotic kinesin Eg5, a motor protein required for spindle bipolarity.
A10828 SALE

SB 743921

KSP Inhibitor
SB 743921, a second generation KSP inhibitor, is a highly potent and active therapeutic in preclinical models of cancer.
A11170 SALE

AZ 3146

Mps1 inhibitor

AZ 3146 is a potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM). It interferes with chromosome alignment and overrides spindle assembly checkpoint and also Inhibits the recruitment of Mad1, Mad2 and centromere protein E (CENP-E) to kinetochores.

A10486 SALE

Ispinesib (SB-715992)

KSP Inhibitor
Ispinesib (SB-715992) is a potent inhibitor of kinesin spindle protein, a kinesin motor protein essential for the formation of a bipolar mitotic spindle and cell cycle progression through mitosis.


Kinesin inhibitor
EMD534085 is a kinesin inhibitor currently in clinical development.

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