Kinesin

Catalog No.Inhibitor Name Kinesin
A10486Ispinesib
***
A10828SB743921
****
A11170AZ 3146
*
A11435GSK923295
**
A14290MPI-0479605
***
A14234ARQ 621

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Arry-520 (Filanesib)

    Catalog No. A11050
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    KSP inhibitor
    KSP inhibitor ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5) with potential antineoplastic activity. Learn More
  2. K 858

    Catalog No. A15844
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    Kinesin Eg5 inhibitor
    K 858 is a selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor with IC50 value of 1.3 uM. Learn More
  3. Dimethylenastron

    Catalog No. A15841
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    Kinesin Eg5 inhibitor
    Dimethylenastron is an inhibitor of mitotic motor kinesin Eg5 with IC50 value of 200 nM. Learn More
  4. ARRY-520 R enantiomer

    Catalog No. A15001
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    KSP inhibitor
    ARRY-520 R enantiomer is the R form of ARRY-520, which is a synthetic, small molecule kinesin spindle protein (KSP) inhibitor with IC50 of 6 nM. Learn More
  5. MPI-0479605

    Catalog No. A14290
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    Mps1 inhibitor
    MPI-0479605 is an ATP competitive and selective inhibitor of mitotic kinase Mps1 Learn More
  6. ARQ 621

    Catalog No. A14234
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    Eg5 mitotic motor protein inhibitor
    ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Learn More
  7. CW069

    Catalog No. A13735
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    Microtubule Associated inhibitor
    CW069 is an allosteric, and selective inhibitor of microtubule motor protein HSET with IC50 of 75 uM, significant selectivity over KSP. Learn More
  8. GSK-923295

    Catalog No. A11435
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    CENP-E inhibitor
    GSK-923295, is a small-molecule inhibitor of the mitotic kinesin centromere-associated protein E, (CENP-E). Learn More
  9. Monastrol

    Catalog No. A11976
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    Kinesin-5(KIF11) inhibitor
    Monastrol is a potent, cell permeable non-tubulin-interacting mitosis inhibitor. Monastrol blocks mitosis (IC5N/A = 14 μM) by binding to the mitotic kinesin Eg5, a motor protein required for spindle bipolarity. Learn More
  10. SB 743921

    Catalog No. A10828
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    KSP Inhibitor
    SB 743921, a second generation KSP inhibitor, is a highly potent and active therapeutic in preclinical models of cancer. Learn More
  11. AZ 3146

    Catalog No. A11170
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    Mps1 inhibitor

    AZ 3146 is a potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM). It interferes with chromosome alignment and overrides spindle assembly checkpoint and also Inhibits the recruitment of Mad1, Mad2 and centromere protein E (CENP-E) to kinetochores.

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  12. Ispinesib (SB-715992)

    Catalog No. A10486
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    KSP Inhibitor
    Ispinesib (SB-715992) is a potent inhibitor of kinesin spindle protein, a kinesin motor protein essential for the formation of a bipolar mitotic spindle and cell cycle progression through mitosis. Learn More
  13. EMD534085

    Catalog No. A15956
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    Kinesin inhibitor
    EMD534085 is a kinesin inhibitor currently in clinical development. Learn More

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