Orexin Receptors

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  1. Lemborexant

    Catalog No. A21289
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    orexin OX1/OX2 receptors antagonist
    Lemborexant (E-2006) is a reversible, competitive and orally active dual antagonist of the orexin OX1 and OX2 receptors with IC50 values of 6.1 nM and 2.6 nM, respectively. Lemborexant can be treated insomnia. Learn More
  2. SB-334867 free base

    Catalog No. A16695
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    orexin OX1 receptor antagonist
    SB-334867 free base is a selective non-peptide orexin OX1 receptor antagonist with a pKb value of 7.2. Learn More
  3. Orexin 2 Receptor Agonist

    Catalog No. A15982
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    Orexin 2 receptor agonist
    A potent and selective Orexin2 receptor agonist. Learn More
  4. MK-1064

    Catalog No. A16360
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    OX2 Antagonist
    MK-1064 is a potent, selective and orally active Orexin OX2 Receptor Antagonist for potential treatment of insomnia. Learn More
  5. Alverine Citrate

    Catalog No. A16396
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    Alverine citrate is a drug used for functional gastrointestinal disorders. Learn More
  6. MK-6096 (Filorexant)

    Catalog No. A13168
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    Orexin receptor antagonist
    MK6096, also known as filorexant, is an orally bioavailable potent and selective reversible antagonist of OX(1)R and OX(2)R currently in clinical development for insomnia. MK-6096 demonstrated potent binding and antagonism of both human OX(1)R and OX(2)R (<3 nM in binding, 11 nM in FLIPR), with no significant off-target activities against a panel of >170 receptors and enzymes. Learn More
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    TCS-OX2-29 HCl

    Catalog No. A17136
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    OX2 receptor antagonist
    TCS-OX2-29 is a selective OX2 receptor antagonist with IC50 value of 40 nM. CAS: 1610882-30-8 (HCl) 372523-75-6 (Free Base) Learn More
  7. GSK1059865

    Catalog No. A12401
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    orexin 1 receptor antagonist
    GSK1059865 is a potent orexin 1 receptor antagonist. Learn More
  8. Nemorexant

    Catalog No. A12685
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    orexin receptor antagonist
    Nemorexant (ACT-541468) is a potent orexin receptor antagonist extracted from patent WO2015083094A1, compound example 7, has IC50s of 2 nM and 3 nM for Ox1 receptor and Ox2 receptor, respectively. Learn More
  9. SB-674042

    Catalog No. A15233
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    OX1 receptor antagonist
    SB-674042 is a potent and selective non-peptide orexin OX1 receptor antagonist (Kd = 3.76 nM); exhibits 100-fold selectivity for OX1 over OX2 receptors. Learn More
  10. SB-408124 HCl

    Catalog No. A15231
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    OX Receptor Antagonist
    SB408124 Hcl is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively; exhibits 50-fold selectivity over OX2 receptor. Learn More
  11. ACT-335827

    Catalog No. A13778
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    OX1 Antagonist
    ACT-335827 is a selective orexin receptor 1 antagonist. Learn More
  12. SB-408124

    Catalog No. A11567
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    OX Receptor Antagonist
    SB-408124 is a selective non-peptide orexin OX1 receptor antagonist (Kb values are 21.7 and 1405 nM for human OX1 and OX2 receptors respectively). Blocks orexin-A induced grooming following oral administration in vivo. Learn More
  13. SB-649868

    Catalog No. A12651
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    Orexin Antagonist
    SB-649868 is an orexin receptor antagonist in development by GlaxoSmithKline. Learn More
  14. SB 334867

    Catalog No. A12786
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    OX1 receptor antagonist
    SB 334867 is a selective non-peptide orexin OX1 receptor antagonist. pKb values are 7.2 and < 5 for inhibition of intracellular Ca2+ release in CHO cells expressing human OX1 and OX2 receptors respectively. Blocks orexin-A induced grooming and feeding following systemic administration in vivo. Learn More
  15. TCS 1102

    Catalog No. A13439
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    Dual orexin receptor antagonist
    TCS 1102 is a potent, dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively). Learn More
  16. Almorexant

    Catalog No. A12503
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    OX Antagonist
    Almorexant(ACT078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively. Learn More
  17. MK-3697

    Catalog No. A12633
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    OX2 Antagonist
    MK-3697 is a highly potent, orally bioavailable selective orexin 2 receptor antagonists. Learn More
  18. JNJ-10397049

    Catalog No. A14104
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    OX2 receptor antagonist
    JNJ-10397049 is a potent, selective, and bioavailable antagonist of the orexin-2 receptor (OX2R) (KB = 4.5 nM for OX2R versus 1.1 μM for OX1R). Learn More
  19. Almorexant HCl

    Catalog No. A14286
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    OX1/OX2 Antagonist
    Almorexant HCl is an orally active, dual orexin receptor antagonist with IC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor 3. Learn More
  20. MK-4305 (Suvorexant)

    Catalog No. A11500
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    OX receptor antagonist
    Suvorexant (MK-4305) is a potent, selective, and orally bioavailable antagonist of OX1R and OX2R currently under clinical investigation as a novel therapy for insomnia. Learn More

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