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Orexin Receptors

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Catalog No. Product Name Application Product Information
A11500 SALE

MK-4305 (Suvorexant)

OX receptor antagonist
Suvorexant (MK-4305) is a potent, selective, and orally bioavailable antagonist of OX1R and OX2R currently under clinical investigation as a novel therapy for insomnia.


OX2 Antagonist
MK-1064 is a potent, selective and orally active Orexin OX2 Receptor Antagonist for potential treatment of insomnia.

Orexin 2 Receptor Agonist

Orexin 2 receptor agonist
A potent and selective Orexin2 receptor agonist.


OX1 receptor antagonist
SB-674042 is a potent and selective non-peptide orexin OX1 receptor antagonist (Kd = 3.76 nM); exhibits 100-fold selectivity for OX1 over OX2 receptors.

SB-408124 HCl

OX Receptor Antagonist
SB408124 Hcl is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively; exhibits 50-fold selectivity over OX2 receptor.


OX1 Antagonist
ACT-335827 is a selective orexin receptor 1 antagonist.

Almorexant HCl

OX1/OX2 Antagonist
Almorexant HCl is an orally active, dual orexin receptor antagonist with IC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor 3.


OX2 receptor antagonist
JNJ-10397049 is a potent, selective, and bioavailable antagonist of the orexin-2 receptor (OX2R) (KB = 4.5 nM for OX2R versus 1.1 ?M for OX1R).


OX2 Antagonist
MK-3697 is a highly potent, orally bioavailable selective orexin 2 receptor antagonists.


OX Antagonist
Almorexant(ACT078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively.
A13439 SALE

TCS 1102

Dual orexin receptor antagonist
TCS 1102 is a potent, dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively).
A12786 SALE

SB 334867

OX1 receptor antagonist
SB 334867 is a selective non-peptide orexin OX1 receptor antagonist. pKb values are 7.2 and < 5 for inhibition of intracellular Ca2+ release in CHO cells expressing human OX1 and OX2 receptors respectively. Blocks orexin-A induced grooming and feeding following systemic administration in vivo.


Orexin Antagonist
SB-649868 is an orexin receptor antagonist in development by GlaxoSmithKline.
A11567 SALE


OX Receptor Antagonist
SB-408124 is a selective non-peptide orexin OX1 receptor antagonist (Kb values are 21.7 and 1405 nM for human OX1 and OX2 receptors respectively). Blocks orexin-A induced grooming following oral administration in vivo.

Alverine Citrate

Alverine citrate is a drug used for functional gastrointestinal disorders.

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