Orexin Receptors

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  1. SB-334867 free base

    Catalog No. A16695
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    orexin OX1 receptor antagonist
    SB-334867 free base is a selective non-peptide orexin OX1 receptor antagonist with a pKb value of 7.2. Learn More
  2. SB-408124 HCl

    Catalog No. A15231
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    OX Receptor Antagonist
    SB408124 Hcl is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively; exhibits 50-fold selectivity over OX2 receptor. Learn More
  3. Nemorexant

    Catalog No. A12685
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    orexin receptor antagonist
    Nemorexant (ACT-541468) is a potent orexin receptor antagonist extracted from patent WO2015083094A1, compound example 7, has IC50s of 2 nM and 3 nM for Ox1 receptor and Ox2 receptor, respectively. Learn More
  4. GSK1059865

    Catalog No. A12401
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    orexin 1 receptor antagonist
    GSK1059865 is a potent orexin 1 receptor antagonist. Learn More
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    TCS-OX2-29 HCl

    Catalog No. A17136
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    OX2 receptor antagonist
    TCS-OX2-29 is a selective OX2 receptor antagonist with IC50 value of 40 nM. CAS: 1610882-30-8 (HCl) 372523-75-6 (Free Base) Learn More
  5. MK-6096 (Filorexant)

    Catalog No. A13168
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    Orexin receptor antagonist
    MK6096, also known as filorexant, is an orally bioavailable potent and selective reversible antagonist of OX(1)R and OX(2)R currently in clinical development for insomnia. MK-6096 demonstrated potent binding and antagonism of both human OX(1)R and OX(2)R (<3 nM in binding, 11 nM in FLIPR), with no significant off-target activities against a panel of >170 receptors and enzymes. Learn More
  6. Alverine Citrate

    Catalog No. A16396
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    Alverine citrate is a drug used for functional gastrointestinal disorders. Learn More
  7. MK-1064

    Catalog No. A16360
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    OX2 Antagonist
    MK-1064 is a potent, selective and orally active Orexin OX2 Receptor Antagonist for potential treatment of insomnia. Learn More
  8. Orexin 2 Receptor Agonist

    Catalog No. A15982
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    Orexin 2 receptor agonist
    A potent and selective Orexin2 receptor agonist. Learn More
  9. SB-674042

    Catalog No. A15233
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    OX1 receptor antagonist
    SB-674042 is a potent and selective non-peptide orexin OX1 receptor antagonist (Kd = 3.76 nM); exhibits 100-fold selectivity for OX1 over OX2 receptors. Learn More
  10. SB-408124

    Catalog No. A11567
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    OX Receptor Antagonist
    SB-408124 is a selective non-peptide orexin OX1 receptor antagonist (Kb values are 21.7 and 1405 nM for human OX1 and OX2 receptors respectively). Blocks orexin-A induced grooming following oral administration in vivo. Learn More
  11. ACT-335827

    Catalog No. A13778
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    OX1 Antagonist
    ACT-335827 is a selective orexin receptor 1 antagonist. Learn More
  12. Almorexant HCl

    Catalog No. A14286
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    OX1/OX2 Antagonist
    Almorexant HCl is an orally active, dual orexin receptor antagonist with IC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor 3. Learn More
  13. JNJ-10397049

    Catalog No. A14104
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    OX2 receptor antagonist
    JNJ-10397049 is a potent, selective, and bioavailable antagonist of the orexin-2 receptor (OX2R) (KB = 4.5 nM for OX2R versus 1.1 μM for OX1R). Learn More
  14. MK-3697

    Catalog No. A12633
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    OX2 Antagonist
    MK-3697 is a highly potent, orally bioavailable selective orexin 2 receptor antagonists. Learn More
  15. Almorexant

    Catalog No. A12503
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    OX Antagonist
    Almorexant(ACT078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively. Learn More
  16. TCS 1102

    Catalog No. A13439
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    Dual orexin receptor antagonist
    TCS 1102 is a potent, dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively). Learn More
  17. SB 334867

    Catalog No. A12786
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    OX1 receptor antagonist
    SB 334867 is a selective non-peptide orexin OX1 receptor antagonist. pKb values are 7.2 and < 5 for inhibition of intracellular Ca2+ release in CHO cells expressing human OX1 and OX2 receptors respectively. Blocks orexin-A induced grooming and feeding following systemic administration in vivo. Learn More
  18. SB-649868

    Catalog No. A12651
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    Orexin Antagonist
    SB-649868 is an orexin receptor antagonist in development by GlaxoSmithKline. Learn More

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