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$0.00 Orexin Receptors
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SB-334867 free base
Catalog No. A16695 orexin OX1 receptor antagonistSB-334867 free base is a selective non-peptide orexin OX1 receptor antagonist with a pKb value of 7.2. Learn More -
SB-408124 HCl
Catalog No. A15231 OX Receptor AntagonistSB408124 Hcl is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively; exhibits 50-fold selectivity over OX2 receptor. Learn More -
Nemorexant
Catalog No. A12685 orexin receptor antagonistNemorexant (ACT-541468) is a potent orexin receptor antagonist extracted from patent WO2015083094A1, compound example 7, has IC50s of 2 nM and 3 nM for Ox1 receptor and Ox2 receptor, respectively. Learn More -
GSK1059865
Catalog No. A12401 orexin 1 receptor antagonistGSK1059865 is a potent orexin 1 receptor antagonist. Learn More -
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TCS-OX2-29 HCl
Catalog No. A17136 OX2 receptor antagonistTCS-OX2-29 is a selective OX2 receptor antagonist with IC50 value of 40 nM. CAS: 1610882-30-8 (HCl) 372523-75-6 (Free Base) Learn More -
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MK-6096 (Filorexant)
Catalog No. A13168 Orexin receptor antagonistMK6096, also known as filorexant, is an orally bioavailable potent and selective reversible antagonist of OX(1)R and OX(2)R currently in clinical development for insomnia. MK-6096 demonstrated potent binding and antagonism of both human OX(1)R and OX(2)R (<3 nM in binding, 11 nM in FLIPR), with no significant off-target activities against a panel of >170 receptors and enzymes. Learn More -
Alverine Citrate
Catalog No. A16396 Alverine citrate is a drug used for functional gastrointestinal disorders. Learn More -
MK-1064
Catalog No. A16360 OX2 AntagonistMK-1064 is a potent, selective and orally active Orexin OX2 Receptor Antagonist for potential treatment of insomnia. Learn More -
Orexin 2 Receptor Agonist
Catalog No. A15982 -
SB-674042
Catalog No. A15233 OX1 receptor antagonistSB-674042 is a potent and selective non-peptide orexin OX1 receptor antagonist (Kd = 3.76 nM); exhibits 100-fold selectivity for OX1 over OX2 receptors. Learn More -
SB-408124
Catalog No. A11567 OX Receptor AntagonistSB-408124 is a selective non-peptide orexin OX1 receptor antagonist (Kb values are 21.7 and 1405 nM for human OX1 and OX2 receptors respectively). Blocks orexin-A induced grooming following oral administration in vivo. Learn More -
ACT-335827
Catalog No. A13778 -
Almorexant HCl
Catalog No. A14286 OX1/OX2 AntagonistAlmorexant HCl is an orally active, dual orexin receptor antagonist with IC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor 3. Learn More -
JNJ-10397049
Catalog No. A14104 OX2 receptor antagonistJNJ-10397049 is a potent, selective, and bioavailable antagonist of the orexin-2 receptor (OX2R) (KB = 4.5 nM for OX2R versus 1.1 μM for OX1R). Learn More -
MK-3697
Catalog No. A12633 OX2 AntagonistMK-3697 is a highly potent, orally bioavailable selective orexin 2 receptor antagonists. Learn More -
Almorexant
Catalog No. A12503 OX AntagonistAlmorexant(ACT078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively. Learn More -
TCS 1102
Catalog No. A13439 Dual orexin receptor antagonistTCS 1102 is a potent, dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively). Learn More -
SB 334867
Catalog No. A12786 OX1 receptor antagonistSB 334867 is a selective non-peptide orexin OX1 receptor antagonist. pKb values are 7.2 and < 5 for inhibition of intracellular Ca2+ release in CHO cells expressing human OX1 and OX2 receptors respectively. Blocks orexin-A induced grooming and feeding following systemic administration in vivo. Learn More -
SB-649868
Catalog No. A12651 Orexin AntagonistSB-649868 is an orexin receptor antagonist in development by GlaxoSmithKline. Learn More
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