Potassium Channels

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  1. Cisapride

    Catalog No. A21340
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    hERG potassium channel inhibitor
    Cisapride(R 51619) is a nonselective 5-HT4 receptor agonist, it is also a potent hERG potassium channel inhibitor. Learn More
  2. ML277

    Catalog No. A21749
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    KCNQ1 potassium channel activator
    ML277(CID53347902) is a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator with EC50 of 270 nM. Learn More
  3. VU591

    Catalog No. A21362
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    potassium channel inhibitor
    VU591 is a potent, selective renal outer medullary potassium channel (ROMK or Kir1.1) inhibitor, with an IC50 of 0.24 μM. Learn More
  4. Digoxin

    Catalog No. A14242
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    sodium-potassium pump inhibitor
    Digoxin is a sodium-potassium pump inhibitor. Learn More
  5. K+ Channel inhibitor

    Catalog No. A16182
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    K+ Channel inhibitor
    K+ Channel inhibitor, building block for synthesis of dihydropyrazolopyrimidine inhibitors of Kv1.5 (IKur). Learn More
  6. Doxapram

    Catalog No. A15961
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    Doxapram inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively. Doxapram is a respiratory stimulant. Administered intravenously, doxapram stimulates an increase in tidal volume, and respiratory rate. Learn More
  7. NS1619

    Catalog No. A15975
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    Potassium channel activator
    NS1619 is a Bkca opener or large-conductance Ca2+-activated potassium (BKCa, KCa1.1) channel activator. Learn More
  8. TAK-438 (vonoprazan)

    Catalog No. A11239
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    potassium-competitive acid Blocker
    TAK-438 is a novel potassium-competitive acid blocker. Learn More
  9. NS-1643

    Catalog No. A15929
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    hERG channel activator
    NS-1643 is a Human ether-a-go-go related gene (hERG) KV11.1 channel activator (EC50 = 10.5 uM). Learn More
  10. ICA-110381

    Catalog No. A15503
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    KV7.2/7.3 activator
    ICA-110381 is a KV7.2/7.3 activator with EC50 of 0.38 uM. Learn More
  11. Cesium chloride

    Catalog No. A15341
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    Potassium channel blocker
    Cesium chloride is a potassium channel blocker; inhibits the pacemaker current (If) and the hyperpolarization-activated cationic current (Ih). Prevents activation of caspase-3 and neuronal apoptosis in serum- and potassium-deprived cerebellar granule neurons by inactivating GSK-3β. Learn More
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    SKA-31

    Catalog No. A17117
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    potassium channel activator
    SKA-31 is an activator of KCa2 and KCa3.1 calcium-activated potassium channels. Learn More
  12. 4-Aminopyridine

    Catalog No. A17490
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    Potassium channel blocker
    Dalfampridine is a potassium channel blocker used to help multiple sclerosis patients walk. Learn More
  13. AUT1

    Catalog No. A18648
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    Kv3 potassium channel modulator
    AUT1 is a Kv3 potassium channel modulator with pEC50s of 5.33 and 5.31 for human recombinant Kv3.1b and Kv3.2a, respectively, exhibits 10-fold lower potency at human recombinant Kv3.3 channel (pEC50, 4.5). Learn More
  14. ML418

    Catalog No. A18426
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    Kir7.1 potassium channels blocker
    ML418 is a selective, sub-micromolar pore blocker of Kir7.1 potassium channels. The inward rectifier potassium (Kir) channel Kir7.1 (KCNJ13) is a key regulator of melanocortin signaling in the brain, electrolyte homeostasis in the eye, and uterine muscle contractility during pregnancy. Learn More
  15. Y-26763

    Catalog No. A12271
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    K+ (KATP) channel activator
    Y-26763 is a K+ channel opener and active metabolite of Y-27152. Y-26763 is an ATP-sensitive K+ (KATP) channel activator. Learn More
  16. JNJ 303

    Catalog No. A20952
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    IKs blocker
    JNJ 303 is a potent IKs blocker with an IC50 value of 64 nM. Learn More
  17. RPR-260243

    Catalog No. A20977
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    HERG activator
    RPR-260243 is a novel activator of HERG; modifies HERG currents inhibited by dofetilide (IC50 = 58 nM); little effect on HERG current amplitude and no significant effects on steady-state activation parameters or on channel inactivation processes. Learn More
  18. KB130015

    Catalog No. A15493
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    hERG1 potassium channel activator
    KB130015 is a novel activator of hERG1 potassium channels, blocking native and recombinant hERG1 channels at high voltages, but activating them at low voltages. Learn More
  19. Vernakalant HCl

    Catalog No. A15275
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    Ion channel blocker
    Vernakalant Hcl is an investigational mixed ion channel blocker that can terminate acute atrial fibrillation (AF) in humans at 2 to 5 mg/kg and may be more atrial-selective than available agents; in treatment of antiarrhythmic. Learn More
  20. Retigabine dihydrochloride

    Catalog No. A15222
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    KCNQ channel opener
    Retigabine dihydrochloride is a Kv7.2-7.5 (KCNQ2-5) neuronal potassium channel opener witrh anticonvulsant activity. Learn More
  21. Orphenadrine citrate

    Catalog No. A11712
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    NMDA receptor antagonist
    Orphenadrine citrate is a NMDA receptor antagonist with Ki of 6.0 +/- 0.7 μM, HERG potassium channel blocker. Learn More
  22. NS 309

    Catalog No. A11934
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    KCa3.1 channel activator
    NS 309 is a positive modulator of small- and intermediate- conductance Ca2+-activated K+ channels (KCa2 and KCa3.1 channels). Learn More
  23. Glimepiride

    Catalog No. A10430
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    Kir6.2/SUR inhibitor
    Glimepiride is a potent Kir6.2/SUR inhibitor with IC50 of 3.0 nM, 5.4 nM, and 7.3 nM for SUR1, SUR2A and SUR2B, used in the treatment of type 2 diabetes mellitus. Learn More
  24. Retigabine (Ezogabine)

    Catalog No. A11922
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    Retigabine is an anticonvulsant used as a treatment for partial epilepsies. Learn More
  25. Hydralazine hydrochloride

    Catalog No. A10455
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    Hydralazine hydrochloride is a hydrochloride salt of hydralazine (Apresoline) that is a direct-acting smooth muscle relaxant with an IC50 of 1.9 mM. Learn More
  26. Minoxidil (U-10858)

    Catalog No. A10593
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    Minoxidil (U-10858) is a selective ATP dependent K+ (Kir6) channel activator. Learn More
  27. Nateglinide (Starlix)

    Catalog No. A10629
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    Nateglinide(Starlix) is an insulin secretagog agent that lowers blood glucose levels by stimulating insulin secretion from the pancreas. Learn More
  28. Mitiglinide calcium

    Catalog No. A11884
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    KATP channel antagonist
    Mitiglinide is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells. Learn More
  29. PAP-1 (5-(4-Phenoxybutoxy)psoralen)

    Catalog No. A11521
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    Kv1.3 blocker
    PAP-1 is a selective inhibitor of Kv1.3, voltage-gated potassium channel. PAP-1 (EC50=2 nM) potently inhibits human T effector memory cell proliferation and delayed hypersensitivity. Learn More
  30. TRAM-34

    Catalog No. A12783
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    Potassium Channel Blocker
    TRAM-34 is a highly selective blocker of intermediate conductance Ca2+-activated K+ channels (KCa3.1) (Kd = 20 nM). Exhibits 200-1500-fold selectivity over KV, BKCa, KCa2, Na+, CRAC and Cl- channels. Suppresses the reactivation of lymphocytes by mitogenic stimuli. Learn More
  31. E-4031 dihydrochloride

    Catalog No. A12857
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    K+ channel blocker‎
    E-4031 dihydrochloride is a selective blocker of KV11.1 (hERG) channels; inhibits the rapid delayed-rectifier K+ current (IKr). Learn More
  32. Glyburide

    Catalog No. A10433
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    K+ channel and CFTR Cl- channel blocker
  33. Nicorandil

    Catalog No. A10641
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    Kir6 (KATP) channel opener
    Nicorandil (SG-75) is potassium channel activator. Learn More
  34. Repaglinide

    Catalog No. A10783
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    Potassium Channel inhibitor
    Repaglinide is a potent short-acting insulin secretagogue that acts by closing ATP-sensitive potassium (KATP) channels in the plasma membrane of the pancreatic beta cell. Learn More
  35. GW 542573X

    Catalog No. A13944
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    KCa2.1 channels activator
    GW 542573X is an activator of small-conductance Ca2+-activated K+ channels (KCa2). Learn More
  36. 20-HETE

    Catalog No. A14971
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    20-HETE is a potent vasoconstrictor produced in vascular smooth muscle (VSM) cells. Learn More
  37. MK-7145

    Catalog No. A21030
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    ROMK inhibitor
    MK-7145 is a ROMK inhibitor, with an IC50 of 0.045 μM. Learn More

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