Reverse Transcriptase

Catalog No.Inhibitor Name Reverse TranscriptaseOther
A10306Didanosine
**
A12587Dapivirine (TMC120)
***
A10908Tenofovir
A10909Tenofovir Disoproxil Fumarate
A10349Emtricitabine
A11216Entecavir Hydrate
A10039Adefovir Dipivoxil
A10639Nevirapine
A10512Lamivudine
A15428Zidovudine
A11120Abacavir sulfate
A11542Rilpivirine

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Loviride

    Catalog No. A21996
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    non-nucleoside reverse transcriptase inhibitor
    Loviride (R 89439) is a non-nucleoside reverse transcriptase inhibitor (NNRTI), with an IC50 of 0.3 ?M for reverse transcriptase from HIV-1. Loviride (R 89439) inhibits HIV-1, HIV-2 and SIV replication in MT-4 cells. Learn More
  2. 4'-Ethynyl-2'-deoxyadenosine

    Catalog No. A18513
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    nucleoside reverse transcriptase (RT) inhibitor
    4'-Ethynyl-2'-deoxyadenosine (4'-E-dA), a nucleoside reverse transcriptase (RT) inhibitor, is an antiretroviral agent which is potent against drug-resistant HIV variants, with an EC50 of 98 nM in MT-4 cells for anti-HIV-1 activity. Learn More
  3. Etravirine ( R165335, TMC125)

    Catalog No. A11417
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    NNRT inhibitor
    Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV. Learn More
  4. MIV-150

    Catalog No. A12060
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    NNRT inhibitor
    MIV-150 is a nonnucleoside reverse transcriptase (NNRT) inhibitor, blocking HIV-1 and HIV-2 infections, with an EC50<1 nM against HIV-1/HIV-2MN. Learn More
  5. Zalcitabine

    Catalog No. A11005
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    nucleoside analogue reverse transcriptase inhibitor
    Zalcitabine is a potent nucleoside analogue reverse transcriptase inhibitor used in the treatment of HIV infection. Learn More
  6. Tenofovir Disoproxil

    Catalog No. A18041
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    nucleotide reverse transcriptase inhibitor
    Tenofovir Disoproxil (Bis(POC)-PMPA) is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B. Learn More
  7. Tenofovir hydrate

    Catalog No. A18042
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    nucleotide reverse transcriptase inhibitor
    Tenofovir hydrate is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B. Learn More
  8. Tenofovir alafenamide fumarate

    Catalog No. A18049
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    HIV-1 nucleotide reverse transcriptase inhibitor
    Tenofovir alafenamide fumarate (GS-7340 fumarate) is an investigational oral prodrug of Tenofovir. Tenofovir is a HIV-1 nucleotide reverse transcriptase inhibitor. Learn More
  9. Tenofovir alafenamide hemifumarate

    Catalog No. A18050
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    HIV-1 nucleotide reverse transcriptase inhibitor
    Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an investigational oral prodrug of Tenofovir. Tenofovir is a HIV-1 nucleotide reverse transcriptase inhibitor. Learn More
  10. Delavirdine

    Catalog No. A21469
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    non-nucleoside reverse transcriptase inhibitor
    Delavirdine(U 90152) is a potent non-nucleoside reverse transcriptase inhibitor (NNRTI). Learn More
  11. Tenofovir maleate

    Catalog No. A21776
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    nucleotide reverse transcriptase inhibitor
    Tenofovir Disoproxil Fumarate is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B. Learn More
  12. Delavirdine mesylate

    Catalog No. A13274
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    NNRT inhibitor
    Delavirdine is a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). Learn More
  13. (Z)-9-Propenyladenine

    Catalog No. A21687
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    (Z)-9-Propenyladenine is a mutagenic impurity in tenofovir disoproxil fumarate. Tenofovir is an antiretroviral drug known as nucleotide analogue reverse transcriptase (NtART) inhibitor, which blocks reverse transcriptase, a crucial virus enzyme in HIV-1 and HBV. Learn More
  14. GS-7340

    Catalog No. A15772
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    NRT inhibitor
    GS-7340 is a prodrug of tenofovir (TFV) that more efficiently delivers TFV into lymphoid cells and tissues than TFV disoproxil fumarate. Learn More
  15. Zidovudine

    Catalog No. A15428
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    NRTI Inhibitor
    Zidovudine is a nucleoside analog reverse-transcriptase inhibitor (NRTI), a type of antiretroviral drug used for the treatment of HIV/AIDS infection. Azidothymidine decreases CRISPR-mediated homology directed repair (HDR) efficiency. Learn More
  16. Elvucitabine

    Catalog No. A14435
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    NRT inhibitor
    Elvucitabine is an experimental nucleoside reverse transcriptase inhibitor (NRTI). Learn More
  17. Lamivudine

    Catalog No. A10512
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    Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor (nRTI). Learn More
  18. Entecavir hydrate

    Catalog No. A11216
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    Reverse transcriptase inhibitor
    Entecavir hydrate is a nucleoside analog (more specifically, a guanosine analogue) that inhibits reverse transcription, DNA replication and transcription in the viral replication process. Entecavir is an oral antiviral drug used in the treatment of hepatitis B infection. Learn More
  19. Tenofovir Disoproxil Fumarate

    Catalog No. A10909
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    nucleotide reverse transcriptase inhibitor
    Tenofovir Disoproxil Fumarate is employed as an anti-HIV agend and a reverse transcriptase inhibitor. Learn More
  20. Abacavir sulfate

    Catalog No. A11120
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    Transcriptase inhibitor
    Abacavir sulfate is a nucleoside analog reverse transcriptase inhibitor (NRTI); guanosine analog used to treat HIV and AIDS. Learn More
  21. Abacavir

    Catalog No. A11115
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    Transcriptase inhibitor
    Abacavir is a nucleoside analog reverse transcriptase inhibitor (NRTI); guanosine analog used to treat HIV and AIDS. Learn More
  22. Adefovir dipivoxil

    Catalog No. A10039
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    ntRT inhibitor
    Adefovir dipivoxil is an orally-administered nucleotide analog reverse transcriptase inhibitor (ntRTI). It is used for treatment of hepatitis B and herpes simplex virus infection. Learn More
  23. Rilpivirine (R 278474, TMC 278)

    Catalog No. A11542
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    NNRT inhibitor
    Rilpivirine is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) with higher potency, longer half-life and reduced side-effect profile compared with older NNRTIs, such as efavirenz. Learn More
  24. Emtricitabine

    Catalog No. A10349
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    NRT inhibitor
    Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) for the treatment of HIV infection. Learn More
  25. Didanosine

    Catalog No. A10306
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    Reverse transcriptase inhibitor
    Didanosine is a reverse transcriptase inhibitor, effective against HIV and used in combination with other antiretroviral drug therapy as part of highly active antiretroviral therapy (HAART). Learn More
  26. MK-1439

    Catalog No. A12443
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    NNRT inhibitor
    MK-1439 is a non-nucleoside reverse transcriptase inhibitor Learn More
  27. Nevirapine (Viramune)

    Catalog No. A10639
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    Nevirapine (Viramune) is a potent (IC50=84nM) and selective non-nucleoside inhibitor of HIV-1 reverse transcriptase. Learn More
  28. Dapivirine

    Catalog No. A12587
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    HIV reverse transcriptase inhibitor
    Dapivirine is a potent non-nucleoside reverse transcriptase inhibitor (NNRTI) Learn More
  29. Lersivirine (UK-453061)

    Catalog No. A12667
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    NNRT inhibitor
    Lersivirine (UK-453,061) is a next-generation nonnucleoside reverse transcriptase inhibitor, active against wild-type HIV-1 and several nonnucleoside reverse transcriptase inhibitor-resistant strains. Learn More
  30. Tenofovir (Viread)

    Catalog No. A10908
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    HIV reverse transcriptase inhibitor
    Tenofovir is in a class of medications called nucleoside reverse transcriptase inhibitors (NRTIs). It works by decreasing the amount of HIV in the blood. Learn More

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