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| Catalog No. | Inhibitor Name | p70 S6K | p70 S6K1 | RSK1 | RSK2 | RSK3 | RSK4 | Other Targets |
|---|---|---|---|---|---|---|---|---|
| A12452 | BI-D1870 | ** | ** | ** | *** | |||
| A10094 | AT7867 | * | Akt2,PKA,Akt1 | |||||
| A11755 | PF-4708671 | * | ||||||
| A14373 | LJI308 | *** | **** | *** | ||||
| A15527 | LY2584702 Tosylate | **** | ||||||
| A14202 | LY2584702 | **** | ||||||
| A12464 | AT13148 | *** | * | PKA,ROCK2,ROCK1 | ||||
| A11160 | SL 0101-1 | ** | ||||||
| A14372 | LJH685 | **** | **** | **** | ||||
| A11423 | FMK | *** |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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SL 0101-1
Catalog No. A11160 RSK InhibitorSL 0101-1 is a selective inhibitor of p90 ribosomal S6 kinase (RSK) (IC50 = 89 nM for RSK2). It also inhibits the growth of MCF-7 human breast cancer cells with no effect on the normal breast cell line.
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PF 4708671
Catalog No. A11755 S6 kinase inhibitorPF 4708671 is a highly specific inhibitor of p70 ribosomal S6 kinase (S6K1) that inhibits S6K1-mediated phosphorylation of S6 protein in response to IGF-1 , while having no effect on highly related RSK and MSK kinases. Learn More -
BI-D1870
Catalog No. A12452 S6 Kinase inhibitorBI-D1870 is a potent and specific inhibitor of the p90 ribosomal S6 kinase (RSK) isoforms in vitro and in vivo, which inhibits RSK1, RSK2, RSK3 and RSK4 in vitro with an IC50 of 10–30 nM. Learn More -
LJH685
Catalog No. A14372 pan-RSK inhibitorLJH685 is a potent , specific and selective RSK inhibitor, inhibits RSK1, 2, and 3 biochemical activities with IC50 of 4 to 13 nM. Learn More -
LJI308
Catalog No. A14373 RSK inhibitorLJI308 is a new and potent pan-RSK inhibitor, with IC50 of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively. Learn More -
AT7867
Catalog No. A10094 AKT inhibitorAT7867 is a novel and potent inhibitor of both AKT and the downstream kinase p70 S6 kinase (p70S6K) and also of protein kinase A. Learn More -
FMK
Catalog No. A11423 RSK inhibitorFMK is potent, highly specific and irreversible inhibitor of p90 ribosomal protein S6 kinase RSK1 and RSK2; Fmk binds in the CTKD ATP-binding site and inhibits RSK autophosphorylation at Ser386. Fmk induces significant apoptosis in human FGFR3-expressing, t(4;14)-positive multiple myeloma cells. Learn More -
AT13148
Catalog No. A12464 multi-AGC kinase inhibitorAT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors. Learn More -
AT7867 2HCl
Catalog No. A15006 Akt inhibitorAT7867 dihydrochloride is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively, little activity outside the AGC kinase family. Learn More -
LY-2584702 tosylate salt
Catalog No. A15527 p70S6K inhibitorLY-2584702 tosylate salt is an orally available inhibitor of p70S6K signaling; inhibits p70S6K and prevents phosphorylation of the S6 subunit of ribosomes. Learn More -
LY-2584702
Catalog No. A14202 p70S6K inhibitorLY-2584702 is an orally available inhibitor of p70S6K signaling; inhibits p70S6K and prevents phosphorylation of the S6 subunit of ribosomes. Learn More -
BIX-02565
Catalog No. A12692 RSK2 inhibitorBIX 02565 is a novel inhibitor of ribosomal S6 kinase 2 with IC50 value of 1 nM. Learn More -
CMK
Catalog No. A11368 RSK2 kinase inhibitorCMK is a RSK2 kinase inhibitor which exhibits similar potency but less chemical stability compared with FMK. Learn More
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