RSK

Catalog No.Inhibitor Namep70 S6Kp70 S6K1 RSK1 RSK2 RSK3 RSK4Other Targets
A12452BI-D1870
**
**
**
***
A10094AT7867
*
Akt2,PKA,Akt1
A11755PF-4708671
*
A14373LJI308
***
****
***
A15527LY2584702 Tosylate
****
A14202LY2584702
****
A12464AT13148
***
*
PKA,ROCK2,ROCK1
A11160SL 0101-1
**
A14372LJH685
****
****
****
A11423FMK
***

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. LJI308

    Catalog No. A14373
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    RSK inhibitor
    LJI308 is a new and potent pan-RSK inhibitor, with IC50 of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively. Learn More
  2. LJH685

    Catalog No. A14372
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    pan-RSK inhibitor
    LJH685 is a potent , specific and selective RSK inhibitor, inhibits RSK1, 2, and 3 biochemical activities with IC50 of 4 to 13 nM. Learn More
  3. AT7867

    Catalog No. A10094
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    AKT inhibitor
    AT7867 is a novel and potent inhibitor of both AKT and the downstream kinase p70 S6 kinase (p70S6K) and also of protein kinase A. Learn More
  4. LY-2584702

    Catalog No. A14202
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    p70S6K inhibitor
    LY-2584702 is an orally available inhibitor of p70S6K signaling; inhibits p70S6K and prevents phosphorylation of the S6 subunit of ribosomes. Learn More
  5. LY-2584702 tosylate salt

    Catalog No. A15527
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    p70S6K inhibitor
    LY-2584702 tosylate salt is an orally available inhibitor of p70S6K signaling; inhibits p70S6K and prevents phosphorylation of the S6 subunit of ribosomes. Learn More
  6. AT7867 2HCl

    Catalog No. A15006
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    Akt inhibitor
    AT7867 dihydrochloride is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively, little activity outside the AGC kinase family. Learn More
  7. AT13148

    Catalog No. A12464
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    multi-AGC kinase inhibitor
    AT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors. Learn More
  8. FMK

    Catalog No. A11423
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    RSK inhibitor
    FMK is potent, highly specific and irreversible inhibitor of p90 ribosomal protein S6 kinase RSK1 and RSK2; Fmk binds in the CTKD ATP-binding site and inhibits RSK autophosphorylation at Ser386. Fmk induces significant apoptosis in human FGFR3-expressing, t(4;14)-positive multiple myeloma cells. Learn More
  9. BI-D1870

    Catalog No. A12452
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    S6 Kinase inhibitor
    BI-D1870 is a potent and specific inhibitor of the p90 ribosomal S6 kinase (RSK) isoforms in vitro and in vivo, which inhibits RSK1, RSK2, RSK3 and RSK4 in vitro with an IC50 of 10–30 nM. Learn More
  10. PF 4708671

    Catalog No. A11755
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    S6 kinase inhibitor
    PF 4708671 is a highly specific inhibitor of p70 ribosomal S6 kinase (S6K1) that inhibits S6K1-mediated phosphorylation of S6 protein in response to IGF-1 , while having no effect on highly related RSK and MSK kinases. Learn More
  11. SL 0101-1

    Catalog No. A11160
    RSK Inhibitor

    SL 0101-1 is a selective inhibitor of p90 ribosomal S6 kinase (RSK) (IC50 = 89 nM for RSK2). It also inhibits the growth of MCF-7 human breast cancer cells with no effect on the normal breast cell line.

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  12. BIX-02565

    Catalog No. A12692
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    RSK2 inhibitor
    BIX 02565 is a novel inhibitor of ribosomal S6 kinase 2 with IC50 value of 1 nM. Learn More

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