S1P Receptor

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  1. PF429242 dihydrochloride

    Catalog No. A21386
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    S1P inhibitor
    PF429242 dihydrochloride is a reversible and competitive S1P inhibitor with an IC50 of 175 nM. Learn More
  2. FTY720 (S)-Phosphate

    Catalog No. A21324
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    S1PR1 agonist
    FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury. Learn More
  3. Cenerimod

    Catalog No. A20913
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    S1P1 agonist
    Cenerimod (ACT-334441) is a potent and orally available sphingosine 1-phosphate 1 receptor (S1P1) agonist extracted from patent WO 2016184939 A1 and WO 2011007324 A1, example 1, with an EC50 of 2.7 nM. Learn More
  4. TY-52156

    Catalog No. A12265
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    S1P3 receptor antagonist
    TY-52156 is a potent and selective S1P3 receptor antagonist with a Ki value of 110 nM. Learn More
  5. VPC 23019

    Catalog No. A20102
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    S1P antagonist
    VPC 23019, an aryl amide-containing Sphingosine 1-phosphate (S1P) analog, is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively) and an agonist at the S1P4 and S1P5 receptors (pEC50= 6.58 and 7.07, respectively). Learn More
  6. MP-A08

    Catalog No. A16290
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    ATP competitive SK inhibitor
    MP-A08 is a highly selective ATP competitive SK inhibitor that targets both SK1 and SK2 with Kivalues of 6.9 ±0.8 uM and 27 ± 3 uM, respectively. Learn More
  7. K145 hydrochloride

    Catalog No. A16289
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    SphK2 inhibitor
    K145 is a selective sphingosine kinase-2 (SphK2) inhibitor and anticancer agent. Learn More
  8. K145

    Catalog No. A16288
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    SphK2 inhibitor
    K145 is a selective SphK2 inhibitor with an IC50 of 4.30± 0.06 μM , while no inhibition of SphK1 at concentrations up to 10 uM. Learn More
  9. Ponesimod

    Catalog No. A13307
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    S1P1 receptor modulator
    Ponesimod is an orally active, selective sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator with EC50 of 5.7 nM. Learn More
  10. BAF312 (Siponimod)

    Catalog No. A12906
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    S1PR1/S1PR5 inhibitor
    BAF312 is a next-generation potent sphingosine 1-phosphate (S1P) receptor agonist, selective for S1P1 and S1P5. Learn More
  11. PF-543

    Catalog No. A13039
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    SphK1 inhibitor
    PF-543 is a novel selective SK-1 inhibitor which inhibited SK-1 activity in a competitive manner with sphingosine. Learn More
  12. ABC294640

    Catalog No. A12614
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    SphK2 inhibitor
    ABC294640 is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Learn More
  13. CYM 5442 HCl

    Catalog No. A13637
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    EDG-1 (S1P1) agonist
    CYM 5442 HCl is a potent and selective EDG-1 (S1P1) agonist in vitro (EC50 = 1.35 nM). Learn More
  14. ASP1126

    Catalog No. A18432
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    S1P agonist
    ASP1126 is a selective and orally active sphingosine-1-phosphate (S1P) agonist, with EC50 values of 7.12 nM, 517 nM for hS1P1 and hS1P3, respectively. Learn More
  15. Fingolimod

    Catalog No. A17798
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    S1P antagonist
    Fingolimod is a sphingosine 1-phosphate (S1P) antagonist with IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant. Learn More
  16. KRP-203

    Catalog No. A13308
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    S1PR1 inhibitor
    KRP-203 is a selective Sphingosine-1-phosphate receptor agonist. It shows to reduce peripheral lymphocyte infiltration and to prolong survival in rat transplant models. Learn More
  17. PF-543 Citrate

    Catalog No. A15210
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    SphK1 Inhibitor
    PF-543 Citrate is a novel cell-permeant inhibitor of SphK1 with a K(i) of 3.6 nM, PF-543 is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. Learn More
  18. RPC1063 (Ozanimod)

    Catalog No. A15819
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    S1PR1 modulators
    RPC1063 is a selective sphingosine 1 phosphate receptor modulators and methods which may be useful in the treatment of S1P1-?associated diseases. Learn More
  19. NS13001

    Catalog No. A15833
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    SK2 modulator
    NS13001 is a selective SK2/3 modulator that acts as a potential therapeutic agent for treatment of SCA2 and possibly other cerebellar ataxias. Learn More
  20. SKI-II

    Catalog No. A15988
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    SphK Inhibitor
    SKI-II is a selective non-lipid inhibitor of sphingosine kinase (IC50 = 0.5 uM). Learn More
  21. FTY720 (Fingolimod)

    Catalog No. A10408
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    S1P Receptor antagonist
    FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. Learn More

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