S1P Receptor

14 Item(s)

per page

Set Descending Direction
  1. MP-A08

    Catalog No. A16290
    Quick View
    ATP competitive SK inhibitor
    MP-A08 is a highly selective ATP competitive SK inhibitor that targets both SK1 and SK2 with Kivalues of 6.9 ±0.8 uM and 27 ± 3 uM, respectively. Learn More
  2. K145 hydrochloride

    Catalog No. A16289
    Quick View
    SphK2 inhibitor
    K145 is a selective sphingosine kinase-2 (SphK2) inhibitor and anticancer agent. Learn More
  3. K145

    Catalog No. A16288
    Quick View
    SphK2 inhibitor
    K145 is a selective SphK2 inhibitor with an IC50 of 4.30± 0.06 μM , while no inhibition of SphK1 at concentrations up to 10 uM. Learn More
  4. FTY720 (Fingolimod)

    Catalog No. A10408
    Quick View
    S1P Receptor antagonist
    FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. Learn More
  5. SKI-II

    Catalog No. A15988
    Quick View
    SphK Inhibitor
    SKI-II is a selective non-lipid inhibitor of sphingosine kinase (IC50 = 0.5 uM). Learn More
  6. Ponesimod

    Catalog No. A13307
    Quick View
    S1P1 receptor modulator
    Ponesimod is an orally active, selective sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator with EC50 of 5.7 nM. Learn More
  7. NS13001

    Catalog No. A15833
    Quick View
    SK2 modulator
    NS13001 is a selective SK2/3 modulator that acts as a potential therapeutic agent for treatment of SCA2 and possibly other cerebellar ataxias. Learn More
  8. RPC1063 (Ozanimod)

    Catalog No. A15819
    Quick View
    S1PR1 modulators
    RPC1063 is a selective sphingosine 1 phosphate receptor modulators and methods which may be useful in the treatment of S1P1-?associated diseases. Learn More
  9. PF-543 Citrate

    Catalog No. A15210
    Quick View
    SphK1 Inhibitor
    PF-543 Citrate is a novel cell-permeant inhibitor of SphK1 with a K(i) of 3.6 nM, PF-543 is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. Learn More
  10. CYM 5442 HCl

    Catalog No. A13637
    Quick View
    EDG-1 (S1P1) agonist
    CYM 5442 HCl is a potent and selective EDG-1 (S1P1) agonist in vitro (EC50 = 1.35 nM). Learn More
  11. ABC294640

    Catalog No. A12614
    Quick View
    SphK2 inhibitor
    ABC294640 is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Learn More
  12. PF-543

    Catalog No. A13039
    Quick View
    SphK1 inhibitor
    PF-543 is a novel selective SK-1 inhibitor which inhibited SK-1 activity in a competitive manner with sphingosine. Learn More
  13. BAF312 (Siponimod)

    Catalog No. A12906
    Quick View
    S1PR1/S1PR5 inhibitor
    BAF312 is a next-generation potent sphingosine 1-phosphate (S1P) receptor agonist, selective for S1P1 and S1P5. Learn More
  14. KRP-203

    Catalog No. A13308
    Quick View
    S1PR1 inhibitor
    KRP-203 is a selective Sphingosine-1-phosphate receptor agonist. It shows to reduce peripheral lymphocyte infiltration and to prolong survival in rat transplant models. Learn More

14 Item(s)

per page

Set Descending Direction
Rewards