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K145
Catalog No. A16288 SphK2 inhibitorK145 is a selective SphK2 inhibitor with an IC50 of 4.30± 0.06 μM , while no inhibition of SphK1 at concentrations up to 10 uM. Learn More -
PF429242 dihydrochloride
Catalog No. A21386 S1P inhibitorPF429242 dihydrochloride is a reversible and competitive S1P inhibitor with an IC50 of 175 nM. Learn More -
FTY720 (S)-Phosphate
Catalog No. A21324 S1PR1 agonistFTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury. Learn More -
Cenerimod
Catalog No. A20913 S1P1 agonistCenerimod (ACT-334441) is a potent and orally available sphingosine 1-phosphate 1 receptor (S1P1) agonist extracted from patent WO 2016184939 A1 and WO 2011007324 A1, example 1, with an EC50 of 2.7 nM. Learn More -
TY-52156
Catalog No. A12265 S1P3 receptor antagonistTY-52156 is a potent and selective S1P3 receptor antagonist with a Ki value of 110 nM. Learn More -
VPC 23019
Catalog No. A20102 S1P antagonistVPC 23019, an aryl amide-containing Sphingosine 1-phosphate (S1P) analog, is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively) and an agonist at the S1P4 and S1P5 receptors (pEC50= 6.58 and 7.07, respectively). Learn More -
MP-A08
Catalog No. A16290 ATP competitive SK inhibitorMP-A08 is a highly selective ATP competitive SK inhibitor that targets both SK1 and SK2 with Kivalues of 6.9 ±0.8 uM and 27 ± 3 uM, respectively. Learn More -
K145 hydrochloride
Catalog No. A16289 SphK2 inhibitorK145 is a selective sphingosine kinase-2 (SphK2) inhibitor and anticancer agent. Learn More -
Ponesimod
Catalog No. A13307 S1P1 receptor modulatorPonesimod is an orally active, selective sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator with EC50 of 5.7 nM. Learn More -
SKI-II
Catalog No. A15988 SphK InhibitorSKI-II is a selective non-lipid inhibitor of sphingosine kinase (IC50 = 0.5 uM). Learn More -
FTY720 (Fingolimod)
Catalog No. A10408 S1P Receptor antagonistFTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. Learn More -
NS13001
Catalog No. A15833 SK2 modulatorNS13001 is a selective SK2/3 modulator that acts as a potential therapeutic agent for treatment of SCA2 and possibly other cerebellar ataxias. Learn More -
RPC1063 (Ozanimod)
Catalog No. A15819 S1PR1 modulatorsRPC1063 is a selective sphingosine 1 phosphate receptor modulators and methods which may be useful in the treatment of S1P1-?associated diseases. Learn More -
KRP-203
Catalog No. A13308 S1PR1 inhibitorKRP-203 is a selective Sphingosine-1-phosphate receptor agonist. It shows to reduce peripheral lymphocyte infiltration and to prolong survival in rat transplant models. Learn More -
Fingolimod
Catalog No. A17798 S1P antagonistFingolimod is a sphingosine 1-phosphate (S1P) antagonist with IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant. Learn More -
ASP1126
Catalog No. A18432 S1P agonistASP1126 is a selective and orally active sphingosine-1-phosphate (S1P) agonist, with EC50 values of 7.12 nM, 517 nM for hS1P1 and hS1P3, respectively. Learn More -
PF-543 Citrate
Catalog No. A15210 SphK1 InhibitorPF-543 Citrate is a novel cell-permeant inhibitor of SphK1 with a K(i) of 3.6 nM, PF-543 is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. Learn More -
CYM 5442 HCl
Catalog No. A13637 EDG-1 (S1P1) agonistCYM 5442 HCl is a potent and selective EDG-1 (S1P1) agonist in vitro (EC50 = 1.35 nM). Learn More -
ABC294640
Catalog No. A12614 SphK2 inhibitorABC294640 is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Learn More -
PF-543
Catalog No. A13039 SphK1 inhibitorPF-543 is a novel selective SK-1 inhibitor which inhibited SK-1 activity in a competitive manner with sphingosine. Learn More -
BAF312 (Siponimod)
Catalog No. A12906 S1PR1/S1PR5 inhibitorBAF312 is a next-generation potent sphingosine 1-phosphate (S1P) receptor agonist, selective for S1P1 and S1P5. Learn More
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