Proteasome

Inhibitory Selectivity
Catalog No.Inhibitor Name Proteasome20S proteasome
A10160Bortezomib (PS-341)
****
A11043MG-132
*
A11278Carfilzomib (PR-171)
***
A10602MLN9708
***
A10600Ixazomib (MLN2238)
****
A12653ONX-0914 (PR-957)
**
A14181Oprozomib (ONX 0912)
**
A11145Delanzomib (CEP-18770)
***
A10192Celastrol
*
A13650VR23
****
A14146PI-1840
**
A12730Epoxomicin

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A14910

Aclacinomycin A

20S proteasome inhibitor
Aclarubicin A, an anthracycline drug, specific inhibitor of the 20S proteasome chymotrypsin-like activity.
A14922

AM 114

20S proteasome inhibitor
AM 114, a derivative of boronic chalcone, is a potent small-molecule inhibitor of the proteasome that inhibits the chymotrypsin-like activity of the 20S proteasome, with a value of 50% inhibition concentration IC50 of approximately 1 uM, resulting in a significant accumulation of ubiquitinated p53 and other cellular proteins in whole cells without significantly disrupting the interaction of p53 and murine double minute 2 (mdm2) proteins.
A10160 SALE

Bortezomib (Velcade)

Proteasome inhibitor
Bortezomib is a highly selective, reversible inhibitor of the 26S proteasome
A11145 SALE

CEP-18770

Proteasome inhibitor
CEP-18770 is a novel orally active proteasome inhibitor with a favorable tumor selectivity profile for the treatment of MM and other malignancies responsive to proteasome inhibition.
A15427

Clasto-Lactacystin b-lactone

20S proteasome inhibitor
Clasto-lactacystin b-lactone was later identified as the active metabolite of lactacystin, resulting from the elimination of cysteine and the formation of a reactive b-lactone.
A14932

Dihydroeponemycin

Proteasome inhibitor
Dihydroeponemycin is an inhibitor of proteasome and antitumor reagent.
A12730

Epoxomicin

Proteasome inhibitor
Epoxomicin is a potent anti-tumor agent isolated from Actinomycetes that is used as a selective and irreversible inhibitor of the 20S proteasome.
A13711

Gliotoxin

20S proteasome inhibitor
Gliotoxin is an immunosuppressive mycotoxin produced by pathogenic strains of Aspergillus and other fungi.
A12768

Lactacystin

proteasome inhibitor
Lactacystin is a cell-permeable, potent and selective proteasome inhibitor.
A11601

MG-115

Reversible Proteasome Inhibitor
MG-115 is a potent, reversible peptide aldehyde inhibitor of proteasome chymotrypsin-like and caspase-like activities. It induces p53 dependent apoptosis.
A11043 SALE

MG-132

Proteasome inhibitor
MG-132 is a potent cell-permeable inhibitor of proteasome (IC50 = 100 nM) and calpain (IC50 = 1.2 μM).
A12220

MG-262

Proteasome inhibitor
MG-262, a boronic peptide acid, is a potent proteasome inhibitor that selectively and reversibly inhibits the chymotryptic activity of the proteasome.
A10600 SALE

MLN2238

Proteasome Inhibitor
MLN2238 is a potent reversible and specific β5 site of the 20S proteasome inhibitor with an IC50 value of 3.4 nM.
A10602 SALE

MLN9708

Proteasome Inhibitor
MLN9708 is a proteasome inhibitor, which inhibits the activity of the proteasome, blocking the targeted proteolysis normally performed by the proteasome.
A14181 SALE

ONX 0912

-
ONX 0912 is a tripeptide epoxyketone, which inhibits growth and induces apoptosis in MM cells resistant to conventional and bortezomib therapies.
A12653 SALE

ONX-0914

Immunoproteasome inhibitor
ONX 0914 is an immunoproteasome inhibitor with potential treatment applications in autoimmune disorders, such as rheumatoid arthritis, inflammatory bowel disease and lupus. ONX 0914 was designed to be a potent inhibitor of the immunoproteasome with minimal cross-reactivity for the constitutive proteasome.
A14146

PI-1840

reversible proteasome inhibitor
PI-1840 is a novel noncovalent and rapidly reversible proteasome inhibitor with anti-tumor activity.
A11278 SALE

PR-171 (Carfilzomib)

Proteasome inhibitor
PR-171 (Carfilzomib) is a tetrapeptide epoxyketone and a selective proteasome inhibitor. It is an analog of epoxomicin.
A14048

PSI

Proteasome inhibitor
PSI is a proteasome inhibitor that inhibits chymotrypsin-like activity of the proteasome.
A13650

VR23

Proteasome inhibitor‎
VR23 is a small molecule that potently inhibited the activities of trypsin-like proteasomes (IC50 = 1 nM), chymotrypsin-like proteasomes (IC50 = 50-100 nM), and caspase-like proteasomes (IC50 = 3uM).

20 Item(s)

per page

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