Proteasome

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  1. Inhibitor (15)


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Catalog No. Product Name Application Product Information
A12003

(-)-Gallocatechin

-
(-)-Gallocatechin possesses free radical scavenging ability. It inhibits the growth and adherence of P. gingivalis onto the buccal epithelial cells.
A14922

AM 114

20S proteasome inhibitor
AM 114, a derivative of boronic chalcone, is a potent small-molecule inhibitor of the proteasome that inhibits the chymotrypsin-like activity of the 20S proteasome, with a value of 50% inhibition concentration IC50 of approximately 1 uM, resulting in a significant accumulation of ubiquitinated p53 and other cellular proteins in whole cells without significantly disrupting the interaction of p53 and murine double minute 2 (mdm2) proteins.
A10085

Artemether (SM-224)

Derivative of artemisinin
Artemether has been shown to have significant anticancer and antitumor activities. It is demonstrated that artemether caused strong inhibitory effects on brain glioma growth and angiogenesis in rats.
A10160

Bortezomib (Velcade)

Proteasome inhibitor
Bortezomib is a highly selective, reversible inhibitor of the 26S proteasome
A11145

CEP-18770

Proteasome inhibitor
CEP-18770 is a novel orally active proteasome inhibitor with a favorable tumor selectivity profile for the treatment of MM and other malignancies responsive to proteasome inhibition.
A10320

Disulfiram

-
Disulfiram blocks the processing of alcohol in the body by inhibiting acetaldehyde dehydrogenase thus causing an unpleasant reaction when alcohol is consumed.
A12730

Epoxomicin

Proteasome inhibitor
Epoxomicin is a potent anti-tumor agent isolated from Actinomycetes that is used as a selective and irreversible inhibitor of the 20S proteasome.
A13711

Gliotoxin

20S proteasome inhibitor
Gliotoxin is an immunosuppressive mycotoxin produced by pathogenic strains of Aspergillus and other fungi.
A12768

Lactacystin

proteasome inhibitor
Lactacystin is a cell-permeable, potent and selective proteasome inhibitor.
A11043

MG-132

Proteasome inhibitor
MG-132 is a potent cell-permeable inhibitor of proteasome (IC50 = 100 nM) and calpain (IC50 = 1.2 μM).
A10600

MLN2238

Proteasome Inhibitor
MLN2238 is a potent reversible and specific β5 site of the 20S proteasome inhibitor with an IC50 value of 3.4 nM.
A10602

MLN9708

Proteasome Inhibitor
MLN9708 is a proteasome inhibitor, which inhibits the activity of the proteasome, blocking the targeted proteolysis normally performed by the proteasome.
A10617

Nafamostat mesylate

serine protease inhibitor
Nafamostat is an anticoagulant. Broad spectrum serine protease inhibitor. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma.
A12933

P 22077

USP7 inhibitor
P 22077 is a cell-permeable inhibitor of the ubiquitin-specific protease (IC?? = 8.6 ?M) and the closely related deubiquitinase (DUB) USP47.
A11278

PR-171 (Carfilzomib)

Proteasome inhibitor
PR-171 (Carfilzomib) is a tetrapeptide epoxyketone and a selective proteasome inhibitor. It is an analog of epoxomicin.
A11522

Pralatrexate

DHFR inhibitor
Pralatrexate is an antifolate (a folate analogue metabolic inhibitor) designed to accumulate preferentially in cancer cells.
A14048

PSI

Proteasome inhibitor
PSI is a proteasome inhibitor that inhibits chymotrypsin-like activity of the proteasome.
A13650

VR23

Proteasome inhibitor‎
VR23 is a small molecule that potently inhibited the activities of trypsin-like proteasomes (IC50 = 1 nM), chymotrypsin-like proteasomes (IC50 = 50-100 nM), and caspase-like proteasomes (IC50 = 3uM).

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