Adenosine Receptors

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  1. Istradefylline (KW-6002)

    Catalog No. A11451
    A2A antagonist
    Istradefylline (KW-6002) is a selective antagonist at the A2A receptor. It has been found to be useful in the treatment of Parkinson's disease. Learn More
  2. SCH58261

    Catalog No. A15886
    A2A adenosine receptor antagonist
    SCH58261 is a potent and selective A2a adenosine receptor antagonist with Ki of 2.3 nM and 2 nM for rat A2a and bovine A2a, respectively. Learn More
  3. DPCPX

    Catalog No. A16104
    Adenosine A1-R antagonist
    DPCPX, a xanthine derivative, is a very potent and selective Adenosine A1-R antagonist. It displays very modest efficacy against Adenosine A2A-R, Adenosine A2B-R and Adenosine A3-R. Learn More
  4. 2-Chloroadenosine (CADO)

    Catalog No. A16105
    Adenosine A Receptor agonist
    2-Chloroadenosine is a metabolically stable analog of adenosine that behaves as an Adenosine A Receptor agonist (Ki values are 300, 80 and 1900 nM for Adenosine A1-R, Adenosine A2A-R and Adenosine A3-R, respectively). Learn More
  5. CGS 21680 HCl

    Catalog No. A16441
    Adenosine A2 receptor agonist
    CGS 21680 HCl is an adenosine A2 receptor agonist with IC50 of 22 nM, exhibits 140-fold over A1 receptor. Learn More
  6. Regadenoson

    Catalog No. A12541
    A2A adenosine agonist
    Regadenoson was selective agonist for the A2A adenosine receptor versus the A1, A2B, and A3 receptors in binding and functional studies. Regadenoson was also found to be a full and potent agonist to cause coronary vasodilation, a response that has a very large A2A receptor reserve? Learn More
  7. Vipadenant (BIIB-014)

    Catalog No. A13963
    A2A receptor antagonist
    Vipadenant, also known as BIIB014, CEB-4520, is a potent, selective and orally available adenosine A2A receptor antagonist under development for Parkinson's disease. Vipadenant demonstrates strong oral activity in commonly used models of Parkinson's disease. Learn More
  8. Theophylline-7-acetic acid

    Catalog No. A16822
    Adenosine receptor antagonist
    Theophylline-7-acetic acid (Acefylline), acting as an adenosine receptor antagonist, is a stimulant drug of the xanthine chemical class. Learn More
  9. Proxyphylline

    Catalog No. A16821
    A1 adenosine receptors antagonist
    Proxyphylline is a derivative of theophylline which is used as a bronchodilator and for its cardiovascular properties. It selectively antagonizes A1 adenosine receptors (Ki = 82 nM for bovine brain) versus A2 adenosine receptors (Ki = 850 μM for platelets). Learn More
  10. AZD-4635 (HTL1071)

    Catalog No. A16820
    A2AR antagonist
    AZD-4635 (HTL1071) is an oral A2AR antagonist that binds to human A2AR with a Ki of 1.7 nM and with > 30-fold selectivity over other adenosine receptors. Learn More
  11. NECA

    Catalog No. A16962
    adenosine receptor agonist
    NECA is a high-affinity adenosine receptor agonist (Ki values are 6.2, 14, and 20 nM for human A3, A1 and A2A receptors respectively; EC50 = 2.4 μM for human A2B). Learn More
  12. MRS1177

    Catalog No. A16871
    Adenosine A3 receptor
    MRS1177 is a potent and selective human Adenosine A3 receptor (hA3AR) antagonist, with a Ki of 0.3 nM. Learn More
  13. MRS1186

    Catalog No. A16870
    Adenosine A3 receptor
    MRS1186 is a potent and selective human Adenosine A3 receptor (hA3AR) antagonist, with a Ki of 7.66 nM. Learn More
  14. Preladenant

    Catalog No. A13504
    Adenosine A2A receptor antagonist
    Preladenant is a potent and selective antagonist at the adenosine A2A receptor. Learn More
  15. ZM-241385

    Catalog No. A13517
    Adenosine A2A antagonist
    ZM-241385 is a potent and highly selective Adenosine A2A-R antagonist, with a pA2 of 9.02 for Adenosine A2A-R in cardiac vasculature and selectivities of 1000, 91 and 500,000 over Adenosine A1-R, Adenosine A2B-R and Adenosine A3-R sites, respectively. Learn More
  16. IB-MECA

    Catalog No. A14345
    Adenosine A3-R agonist
    IB-MECA has been shown to act as a potent and selective Adenosine A3-R agonist with Ki values of 1.1, 54 and 56 nM for Adenosine A3-R, Adenosine A1-R and Adenosine A2A-R, respectively. Learn More
  17. SYN-115 (Tozadenant)

    Catalog No. A11560
    A2a receptor antagonist
    SYN115 is an orally administered, potent and selective inhibitor of the adenosine 2a (A2a) receptor that is being developed initially for the treatment of Parkinson’s disease, but may also have utility in other CNS disorders. Learn More
  18. CGS 21680 HCl

    Catalog No. A11619
    Adenosine A2A Receptor Agonist
    CGS 21680 is a specific adenosine A2A subtype receptor agonist. Learn More
  19. Adenosine

    Catalog No. A10040
    Adenosine plays an important role in biochemical processes, such as energy transfer-as adenosine triphosphate (ATP) and adenosine diphosphate (ADP)-as well as in signal transduction as cyclic adenosine monophosphate, cAMP. It is also an inhibitory neurotransmitter. Learn More
  20. Aminophylline

    Catalog No. A10066
    Adenosine receptor antagonist
    Aminophylline is a nonselective adenosine receptor antagonist and phosphodiesterase inhibitor capable of reversing ischemia-induced bradyasystole. Learn More
  21. Dyphylline

    Catalog No. A10339
    Adenosine receptor antagonist
    Dyphylline is a xanthine derivative with bronchodilator and vasodilator effects. It acts as an adenosine receptor antagonist and phosphodiesterase inhibitor. Learn More
  22. SCH 442416

    Catalog No. A12695
    A2A Receptor Antagonist
    SCH 442416 is a selective adenosine A2A receptor antagonist; binds to human and rat A2A receptors with high affinity (Ki values are 0.048 and 0.5 nM respectively). Displays > 23000-fold selectivity for hA2A over hA1 in vitro with minimal affinity for hA2B and hA3 receptors (IC50 > 10 μM). Learn More
  23. Tamsulosin hydrochloride

    Catalog No. A12846
    Tamsulosin hydrochloride is an antagonist of alpha1A adrenoceptors in the prostate. Learn More
  24. CVT 6883

    Catalog No. A13745
    adenosine A2B receptors antagonist
    CVT-6883, a selective A2B adenosine antagonist, represents a novel potential approach to treating cardiopulmonary diseases. Learn More
  25. Capadenoson

    Catalog No. A14159
    Adenosine Receptor agonist
    Capadenoson is a selective agonist of adenosine-A1 receptor. Learn More
  26. 5-Iodotubercidin

    Catalog No. A13948
    Adenosine kinase inhibitor
    5-Iodotubercidin is a potent adenosine kinase inhibitor with IC50 of 26 nM. Learn More
  27. CF-102

    Catalog No. A14402
    Adenosine A3 receptor agonist
    CF-102 is an orally bioavailable, synthetic, highly selective adenosine A3 receptor (A3AR) agonist with potential antineoplastic activity. Learn More
  28. CGS-15943

    Catalog No. A14327
    Adenosine A Receptor antagonist
    CGS 15943 is a potent, non-selective Adenosine A Receptor antagonist. It is orally active in vivo. Learn More
  29. MRS1706

    Catalog No. A16868
    adenosine A2B receptor
    MRS1706 is a selective adenosine A2B receptor inverse agonist with Ki values of 1.39, 157, 112, and 230 nM for human A2B, A1, A2A, and A3 receptors, respectively. Learn More

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