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$0.00 Endothelin Receptors
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Macitentan
Catalog No. A11492 Endothelin receptor antagonistMacitentan is an orally active, non-peptide dual endothelin ETA and ETB receptor antagonist for the potential treatment of idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH). Learn More -
Aprocitentan
Catalog No. A21999 dual ETA/ETB antagonistAprocitentan (ACT-132577) is the major and pharmacologically active metabolite of Macitentan. Aprocitentan is dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively. Learn More -
Macitentan (n-butyl analogue)
Catalog No. A21845 endothelin ETA and ETB receptor antagonistMacitentan n-butyl analogue is a n-butyl analogue of Macitentan. Macitentan is an orally active, non-peptide dual endothelin ETA and ETB receptor antagonist for the potential treatment of idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH). Learn More -
Darusentan
Catalog No. A21280 endothelin A (ETA) receptor antagonistDarusentan is a selective endothelin A (ETA) receptor antagonist. Learn More -
Tezosentan
Catalog No. A21118 endothelin (ET) receptor antagonistTezosentan (RO 610612) is an endothelin (ET) receptor antagonist, with pA2s of 9.5, 7.7 for ETA and ETB receptors, respectively. Learn More -
Sparsentan
Catalog No. A20879 angiotensin II and endothelin A receptor antagonistSparsentan (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Kis of 0.8 and 9.3 nM, respectively. Learn More -
Endothelin Mordulator 1
Catalog No. A13040 endothelin receptor modulatorEndothelin Mordulator 1 is a endothelin receptor modulator, used for the research of endothelin-mediated disorders. Learn More -
PD-159020
Catalog No. A13499 ETA/ETB antagonistPD-159020 is a non-selective ETA/ETB antagonist, with IC50s of 30 and 50 nM for hETA and hETB, respectively. Learn More -
RO462005
Catalog No. A13216 endothelin receptor agonistRO462005 is an endothelin receptor selective agonist. Learn More -
IRL-2500
Catalog No. A13638 ETBR antagonistIRL-2500 is a potent, selective ETBR antagonist. It shows some selectivity for ETB receptors (IC50 values are 1.3 and 94 nM for ETB and ETA receptors respectively). Learn More -
Atrasentan HCl
Catalog No. A15007 Endothelin antagonist receptorAtrasentan hydrochloride is an endothelin antagonist receptor (IC50=0.0551 nM, ETA) being developed for the treatment of prostate cancer. Learn More -
Zibotentan (ZD4054)
Catalog No. A11006 ETA-receptor AntagonistZibotentan (ZD4054)is an orally administered, potent and specific ETA-receptor (endothelin A receptor) antagonist (IC50 = 21 nM). Learn More -
Endothelin-2, human
Catalog No. A14894 Endothelin-2, human, endogenous peptide found predominately in the kidney and intestine. Displays similar selectivity for ETA and ETB endothelin receptors. Learn More -
BQ-123
Catalog No. A15912 ETA receptor antagonistBQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2. Learn More -
Bosentan Hydrate
Catalog No. A14944 ET-A and ET-B antagonistBosentan is an endothelin (ET) receptor antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively. Learn More -
Atrasentan
Catalog No. A13779 ETA antagonistAtrasentan is an experimental drug that is being studied for the treatment of various types of cancer, including non-small cell lung cancer. It is an endothelin receptor antagonist selective for subtype A (ETA). Learn More -
BQ-788
Catalog No. A14369 ETBR antagonistBQ-788 sodium salt is a selective ETBR (Endothelin receptor B ) antagonist. Learn More -
Sitaxsentan sodium (TBC-11251)
Catalog No. A11564 ETA receptor antagonistSitaxentan sodium (TBC-11251) is a selective endothelin receptor-A antagonist with IC50 and Ki of 1.4 nM and 0.43 nM, respectively. Learn More -
Avosentan (SPP301)
Catalog No. A11301 Endothelin antagonistAvosentan (SPP301) is a potent and highly selective ETA receptor blocker. Learn More -
Ambrisentan (BSF 208075)
Catalog No. A11291 EndothelinA receptor antagonistAmbrisentan functions as an endothelin receptor antagonist, and is selective for the type A endothelin receptor (ETA). Learn More -
Bosentan
Catalog No. A11091 ETAR/ETBR inhibitorBosentan is a competitive antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors. Learn More
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