Sirtuins

Catalog No.Inhibitor Name SIRT1SIRT2SIRT3SirtuinOther
A10377Selisistat (EX 527)
****
A12226Sirtinol
*
**
A15902SirReal2
****
A14221Splitomicin
**
A14225AGK2
***
A12305Tenovin-6
***
*
p53

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. SRT1720 HCl

    Catalog No. A10862
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    SIRT1 Activator
    SRT1720 is an inhibitor developed intended as a small-molecule activator of the sirtuin subtype SIRT1. Learn More
  2. Sirtinol

    Catalog No. A12226
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    sirtuin inhibitor
    Sirtinol is a cell-permeable, specific inhibitor of sirtuin NAD-dependant histone deacetylases. It is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM in cell-free assays, respectively. Learn More
  3. SirReal2

    Catalog No. A15902
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    Selective SIRT2 inhibitor
    SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM. Learn More
  4. SRT 1720

    Catalog No. A15247
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  5. AK-1

    Catalog No. A14370
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    SIRT2 inhibitor
    AK-1 inhibits SIRT2 selectively over SIRT1 and SIRT3. Learn More
  6. AGK2

    Catalog No. A14225
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    SIRT2 inhibitor
    AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM. Learn More
  7. SRT2104 (GSK2245840)

    Catalog No. A14188
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    SIRT1 activator
    SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2. Learn More
  8. Inauhzin

    Catalog No. A12527
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    SIRT1 inhibitor
    Inauhzin is a potent SIRT inhibitor, which effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress. Learn More
  9. Tenovin-6

    Catalog No. A12305
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    p53 activator
    Tenovin-6 is a analog of tenovin-1. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 values of 21, 10, and 67 uM, respectively. Learn More
  10. AK-7

    Catalog No. A12904
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    SIRT2 inhibitor
    AK-7 is a cell- and brain-permeable inhibitor of SIRT2 (IC50 = 15.5 μM). Learn More
  11. EX 527 (Selisistat)

    Catalog No. A10377
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    SIRT1 inhibitor
    EX 527 is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with IC50 of 38 nM in a cell-free assay. Learn More
  12. Fisetin (Fustel)

    Catalog No. A10388
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    Fisetin is a flavonol, a structurally distinct chemical substance that belongs to the flavonoid group of polyphenols. It can be found in many plants, where it serves as a colouring agent. Possible anti-aging, anti-inflammatory, anti-cancer, and anti-viral properties of fisetin are under active scientific investigation. Learn More
  13. OSS-128167

    Catalog No. A17048
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    SIRT 6 inhibitor
    OSS-128167, also known as SIRT6-IN-1, is a potent and selective SIRT 6 inhibitor with IC50 value of 89 μM. Learn More
  14. Thiomyristoyl

    Catalog No. A17166
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    SIRT2 inhibitor
    Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. Learn More
  15. 3-TYP

    Catalog No. A17144
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    SIRT3 inhibitor
    3-TYP is a SIRT3 inhibitor. Learn More

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