Catalog No.Inhibitor Name SIRT1SIRT2SIRT3SirtuinOther
A10377Selisistat (EX 527)

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2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. SRT1720 HCl

    Catalog No. A10862
    SIRT1 Activator
    SRT1720 is an inhibitor developed intended as a small-molecule activator of the sirtuin subtype SIRT1. Learn More
  2. Sirtinol

    Catalog No. A12226
    sirtuin inhibitor
    Sirtinol is a cell-permeable, specific inhibitor of sirtuin NAD-dependant histone deacetylases. It is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM in cell-free assays, respectively. Learn More
  3. SirReal2

    Catalog No. A15902
    Selective SIRT2 inhibitor
    SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM. Learn More
  4. AK-1

    Catalog No. A14370
    SIRT2 inhibitor
    AK-1 inhibits SIRT2 selectively over SIRT1 and SIRT3. Learn More
  5. AGK2

    Catalog No. A14225
    SIRT2 inhibitor
    AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM. Learn More
  6. SRT2104 (GSK2245840)

    Catalog No. A14188
    SIRT1 activator
    SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2. Learn More
  7. Inauhzin

    Catalog No. A12527
    SIRT1 inhibitor
    Inauhzin is a potent SIRT inhibitor, which effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress. Learn More
  8. Tenovin-6

    Catalog No. A12305
    p53 activator
    Tenovin-6 is a analog of tenovin-1. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 values of 21, 10, and 67 uM, respectively. Learn More
  9. AK-7

    Catalog No. A12904
    SIRT2 inhibitor
    AK-7 is a cell- and brain-permeable inhibitor of SIRT2 (IC50 = 15.5 μM). Learn More
  10. EX 527 (Selisistat)

    Catalog No. A10377
    SIRT1 inhibitor
    EX 527 is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with IC50 of 38 nM in a cell-free assay. Learn More
  11. Fisetin (Fustel)

    Catalog No. A10388
    Fisetin is a flavonol, a structurally distinct chemical substance that belongs to the flavonoid group of polyphenols. It can be found in many plants, where it serves as a colouring agent. Possible anti-aging, anti-inflammatory, anti-cancer, and anti-viral properties of fisetin are under active scientific investigation. Learn More
  12. OSS-128167

    Catalog No. A17048
    SIRT 6 inhibitor
    OSS-128167, also known as SIRT6-IN-1, is a potent and selective SIRT 6 inhibitor with IC50 value of 89 μM. Learn More
  13. Thiomyristoyl

    Catalog No. A17166
    SIRT2 inhibitor
    Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. Learn More
  14. 3-TYP

    Catalog No. A17144
    SIRT3 inhibitor
    3-TYP is a SIRT3 inhibitor. Learn More

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