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$0.00 Sirtuins
| Catalog No. | Inhibitor Name | SIRT1 | SIRT2 | SIRT3 | Sirtuin | Other |
|---|---|---|---|---|---|---|
| A10377 | Selisistat (EX 527) | **** | ||||
| A12226 | Sirtinol | * | ** | |||
| A15902 | SirReal2 | **** | ||||
| A14221 | Splitomicin | ** | ||||
| A14225 | AGK2 | *** | ||||
| A12305 | Tenovin-6 | *** | * | p53 |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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EX 527 (Selisistat)
Catalog No. A10377 SIRT1 inhibitorEX 527 is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with IC50 of 38 nM in a cell-free assay. Learn More -
Sirtinol
Catalog No. A12226 sirtuin inhibitorSirtinol is a cell-permeable, specific inhibitor of sirtuin NAD-dependant histone deacetylases. It is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM in cell-free assays, respectively. Learn More -
SirReal2
Catalog No. A15902 Selective SIRT2 inhibitorSirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM. Learn More -
SRT 1720
Catalog No. A15247 SIRT1 ActivatorSRT 1720 is a selective activator of human SIRT1 (EC1.5 = 0.16 μM) versus the closest sirtuin homologues, SIRT2 and SIRT3 (SIRT2: EC1.5 = 37 uM; SIRT3: EC1.5 > 300 uM). Learn More -
AK-1
Catalog No. A14370 -
AGK2
Catalog No. A14225 SIRT2 inhibitorAGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM. Learn More -
SRT2104 (GSK2245840)
Catalog No. A14188 SIRT1 activatorSRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2. Learn More -
Inauhzin
Catalog No. A12527 SIRT1 inhibitorInauhzin is a potent SIRT inhibitor, which effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress. Learn More -
Tenovin-6
Catalog No. A12305 p53 activatorTenovin-6 is a analog of tenovin-1. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 values of 21, 10, and 67 uM, respectively. Learn More -
AK-7
Catalog No. A12904 SIRT2 inhibitorAK-7 is a cell- and brain-permeable inhibitor of SIRT2 (IC50 = 15.5 μM). Learn More -
SRT1720 HCl
Catalog No. A10862 SIRT1 ActivatorSRT1720 is an inhibitor developed intended as a small-molecule activator of the sirtuin subtype SIRT1. Learn More -
SirReal1-O-propargyl
Catalog No. A20091 Sirt2 inhibitorSirReal1-O-propargyl is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC50 of 2.4 μM. Learn More -
SIRT5 inhibitor 1
Catalog No. A19841 SIRT5 inhibitorSIRT5 inhibitor 1 is a potent Human Sirtuin 5 deacylase inhibitor, with an IC50 of 0.11 μM. Learn More -
JFD00244
Catalog No. A19517 SIRT2 inhibitorJFD00244 is a sirtuin 2 (SIRT2) inhibitor. Anti-tumor effect. Learn More -
Sirt2-IN-1
Catalog No. A19348 Sirt2 inhibitorSirt2-IN-1 (Compound 9) is a sirtuin 2 (Sirt2) inhibitor with an IC50 of 163 nM. Learn More -
SIRT-IN-1
Catalog No. A20962 SIRT1/2/3 inhibitorSIRT-IN-1 is a potent inhibitor of SIRT1/2/3, with IC50s of 15, 10, 33 μM, respectively. Learn More -
SIRT-IN-2
Catalog No. A20961 SIRT1/2/3 inhibitorSIRT-IN-2 is a potent inhibitor of SIRT1/2/3, with IC50s of 4, 4, 7 μM, respectively. Learn More -
SRT 1720 Hydrochloride
Catalog No. A21143 SIRT1 activatorSRT 1720 Hydrochloride is a selective activator of SIRT1 with an EC50 of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3. Learn More -
PROTAC Sirt2 Degrader-1
Catalog No. A20005 Sirt2 degraderPROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase. Learn More -
Salermide
Catalog No. A12263 Sirt1/Sirt2 inhibitorSalermide is an inhibitor of Sirt1 and Sirt2; can cause strong cancer-specific apoptotic cell death. Learn More -
Cambinol
Catalog No. A12381 SIRT1/SIRT2 inhibitorCambinol is a SIRT1 and SIRT2 inhibitor with IC50 values of 56 and 59 μM, respectively. Learn More -
SRT 2183
Catalog No. A12150 Sirtuin-1 (SIRT1) activatorSRT 2183 is a selective Sirtuin-1 (SIRT1) activator with an EC1.5 value of 0.36 μM. SRT 2183 induces growth arrest and apoptosis, concomitant with deacetylation of STAT3 and NF-κB, and reduction of c-Myc protein levels. Learn More -
UBCS039
Catalog No. A18961 SIRT6 activatorUBCS039 is the first synthetic, specific Sirtuin 6 (SIRT6) activator, inducing autophagy in human tumor cells, with an EC50 of 38 μM. Learn More -
SRT 1460
Catalog No. A19026 SIRT1 activatorSRT 1460, a potent Sirtuin-1 (SIRT1) activator with an EC1.5 value of 2.9 μM, shows good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 μM), and is more potent than Resveratrol and the closest sirtuin homologues. Learn More -
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New
MDL-800
Catalog No. A17228 SIRT6 allosteric activatorMDL-800 is a first-in-class cellularly active SIRT6 allosteric activator. Learn More -
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Thiomyristoyl
Catalog No. A17166 SIRT2 inhibitorThiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. Learn More -
OSS-128167
Catalog No. A17048 SIRT 6 inhibitorOSS-128167, also known as SIRT6-IN-1, is a potent and selective SIRT 6 inhibitor with IC50 value of 89 μM. Learn More -
Fisetin (Fustel)
Catalog No. A10388 Fisetin is a flavonol, a structurally distinct chemical substance that belongs to the flavonoid group of polyphenols. It can be found in many plants, where it serves as a colouring agent. Possible anti-aging, anti-inflammatory, anti-cancer, and anti-viral properties of fisetin are under active scientific investigation. Learn More
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