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| Catalog No. | Inhibitor Name | FAK | Other |
|---|---|---|---|
| A12580 | PF-00562271 | **** | CDK2/CyclinE,CDK3/CyclinE,CDK1/CyclinB |
| A11192 | PF-562271 | **** | CDK2/CyclinE,CDK3/CyclinE,CDK1/CyclinB |
| A11235 | PF-573228 | * | |
| A11507 | TAE226 | ** | Insulin Receptor,IGF-1R,c-Met |
| A11171 | PF-03814735 | * | Aurora A,Aurora B,FLT1 |
| A11142 | PF-431396 | ** | |
| A13140 | PND-1186 | **** | |
| A11929 | Defactinib | ||
| A15543 | CEP-37440 | ** | ALK |
| A15765 | GSK2256098 | **** |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
17 Item(s)
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PF-562271 hydrochloride
Catalog No. A22370 FAK and Pyk2 kinase inhibitorPF-562271 hydrochloride is a potent, ATP-competitive and reversible FAK and Pyk2 kinase inhibitor with IC50s of 1.5 nM and 13 nM, respectively. Learn More -
Defactinib hydrochloride
Catalog No. A22003 FAK inhibitorDefactinib hydrochloride (VS-6063 hydrochloride; PF 04554878 hydrochloride) is a novel FAK inhibitor, which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner. Learn More -
PF 573228
Catalog No. A11235 FAK InhibitorPF 573228 is a potent and selective inhibitor of focal adhesion kinase (FAK) (IC50 = 4 nM). Learn More -
PF-04554878 (Defactinib)
Catalog No. A11929 FAK inhibitorPF-04554878 is a novel FAK kinase inhibitor that decreases growth and induces apoptosis in pancreatic neuroendocrine tumor cells Learn More -
Defactinib
Catalog No. A21958 FAK inhibitorDefactinib (VS-6063; PF-04554878) is a novel FAK inhibitor with potential antiangiogenic and antineoplastic activities. Learn More -
Y15
Catalog No. A21472 FAK inhibitorY15 is a potent and specific inhibitor of focal adhesion kinase (FAK) that inhibits its autophosphorylation activity, decreases the viability of cancer cells, and blocks tumor growth. Learn More -
PROTAC FAK degrader 1
Catalog No. A18946 FAK degraderPROTAC FAK degrader 1 is a selective and potent focal adhesion kinase (Fak) degrader with an IC50 of 6.5 nM, DC50 of 3 nM. Learn More -
PF-562271
Catalog No. A11192 FAK inhibitorPF-562271 is an orally bioavailable small molecule and ATP-competitive focal adhesion kinase (FAK) inhibitor with potential antineoplastic and antiangiogenic activities. Learn More -
NVP-TAE 226
Catalog No. A11507 FAK inhibitorNVP-TAE226 is a potent FAK inhibitor with IC50 of 5.5 nM and modestly potent to Pyk2(IC50=3.5 nM); 10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met. Learn More -
GSK2256098
Catalog No. A15765 FAK inhibitorGSK2256098 is a focal adhesion kinase-1 (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. Learn More -
BI-4464
Catalog No. A18894 PTK2/FAK inhibitorBI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC. Learn More -
CEP-37440
Catalog No. A15543 FAK/ALK inhibitorCEP-37440 is a novel potent and selective Dual FAK/ALK inhibitor with IC50 s of 2.3 nM (FAK) and 120 nM(ALK cellular IC50 in 75% human plasma). Learn More -
PF-4618433
Catalog No. A13461 PYK2/FAK inhibitorPF-4618433 shows improved PYK2 potency, reduced p38 activity, and superior overall selectivity relative to the prototype BIRB796. Learn More -
PND-1186
Catalog No. A13140 -
PF-00562271
Catalog No. A12580 FAK inhibitorPF-00562271 is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively. Learn More -
PF-03814735
Catalog No. A11171 Aurora A/B Kinase inhibitorPF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1. Learn More -
PF 431396
Catalog No. A11142 FAK/PYK2 inhibitorPF 431396 is a dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively). Learn More
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