FAK

Catalog No.Inhibitor Name FAKOther
A12580PF-00562271
****
CDK2/CyclinE,CDK3/CyclinE,CDK1/CyclinB
A11192PF-562271
****
CDK2/CyclinE,CDK3/CyclinE,CDK1/CyclinB
A11235PF-573228
*
A11507TAE226
**
Insulin Receptor,IGF-1R,c-Met
A11171PF-03814735
*
Aurora A,Aurora B,FLT1
A11142PF-431396
**
A13140PND-1186
****
A11929Defactinib
A15543CEP-37440
**
ALK
A15765GSK2256098
****

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. GSK2256098

    Catalog No. A15765
    FAK inhibitor
    GSK2256098 is a focal adhesion kinase-1 (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. Learn More
  2. NVP-TAE 226

    Catalog No. A11507
    FAK inhibitor
    NVP-TAE226 is a potent FAK inhibitor with IC50 of 5.5 nM and modestly potent to Pyk2(IC50=3.5 nM); 10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met. Learn More
  3. CEP-37440

    Catalog No. A15543
    FAK/ALK inhibitor
    CEP-37440 is a novel potent and selective Dual FAK/ALK inhibitor with IC50 s of 2.3 nM (FAK) and 120 nM(ALK cellular IC50 in 75% human plasma). Learn More
  4. PF-4618433

    Catalog No. A13461
    PYK2/FAK inhibitor
    PF-4618433 shows improved PYK2 potency, reduced p38 activity, and superior overall selectivity relative to the prototype BIRB796. Learn More
  5. PND-1186

    Catalog No. A13140
    FAK inhibitor
    PND-1186 is a potent FAK inhibitor with IC50 of 1.5 nM. Learn More
  6. PF-00562271

    Catalog No. A12580
    FAK inhibitor
    PF-00562271 is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively. Learn More
  7. PF-04554878 (Defactinib)

    Catalog No. A11929
    FAK inhibitor
    PF-04554878 is a novel FAK kinase inhibitor that decreases growth and induces apoptosis in pancreatic neuroendocrine tumor cells Learn More
  8. PF 573228

    Catalog No. A11235
    FAK Inhibitor
    PF 573228 is a potent and selective inhibitor of focal adhesion kinase (FAK) (IC50 = 4 nM). Learn More
  9. PF-03814735

    Catalog No. A11171
    Aurora A/B Kinase inhibitor
    PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1. Learn More
  10. PF 431396

    Catalog No. A11142
    FAK/PYK2 inhibitor
    PF 431396 is a dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively). Learn More
  11. PF-562271

    Catalog No. A11192
    FAK inhibitor
    PF-562271 is an orally bioavailable small molecule and ATP-competitive focal adhesion kinase (FAK) inhibitor with potential antineoplastic and antiangiogenic activities. Learn More

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