FAK

Catalog No.Inhibitor Name FAKOther
A12580PF-00562271
****
CDK2/CyclinE,CDK3/CyclinE,CDK1/CyclinB
A11192PF-562271
****
CDK2/CyclinE,CDK3/CyclinE,CDK1/CyclinB
A11235PF-573228
*
A11507TAE226
**
Insulin Receptor,IGF-1R,c-Met
A11171PF-03814735
*
Aurora A,Aurora B,FLT1
A11142PF-431396
**
A13140PND-1186
****
A11929Defactinib
A15543CEP-37440
**
ALK
A15765GSK2256098
****

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Defactinib hydrochloride

    Catalog No. A22003
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    FAK inhibitor
    Defactinib hydrochloride (VS-6063 hydrochloride; PF 04554878 hydrochloride) is a novel FAK inhibitor, which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner. Learn More
  2. Defactinib

    Catalog No. A21958
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    FAK inhibitor
    Defactinib (VS-6063; PF-04554878) is a novel FAK inhibitor with potential antiangiogenic and antineoplastic activities. Learn More
  3. Y15

    Catalog No. A21472
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    FAK inhibitor
    Y15 is a potent and specific inhibitor of focal adhesion kinase (FAK) that inhibits its autophosphorylation activity, decreases the viability of cancer cells, and blocks tumor growth. Learn More
  4. PROTAC FAK degrader 1

    Catalog No. A18946
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    FAK degrader
    PROTAC FAK degrader 1 is a selective and potent focal adhesion kinase (Fak) degrader with an IC50 of 6.5 nM, DC50 of 3 nM. Learn More
  5. BI-4464

    Catalog No. A18894
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    PTK2/FAK inhibitor
    BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC. Learn More
  6. GSK2256098

    Catalog No. A15765
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    FAK inhibitor
    GSK2256098 is a focal adhesion kinase-1 (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. Learn More
  7. NVP-TAE 226

    Catalog No. A11507
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    FAK inhibitor
    NVP-TAE226 is a potent FAK inhibitor with IC50 of 5.5 nM and modestly potent to Pyk2(IC50=3.5 nM); 10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met. Learn More
  8. CEP-37440

    Catalog No. A15543
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    FAK/ALK inhibitor
    CEP-37440 is a novel potent and selective Dual FAK/ALK inhibitor with IC50 s of 2.3 nM (FAK) and 120 nM(ALK cellular IC50 in 75% human plasma). Learn More
  9. PF-4618433

    Catalog No. A13461
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    PYK2/FAK inhibitor
    PF-4618433 shows improved PYK2 potency, reduced p38 activity, and superior overall selectivity relative to the prototype BIRB796. Learn More
  10. PND-1186

    Catalog No. A13140
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    FAK inhibitor
    PND-1186 is a potent FAK inhibitor with IC50 of 1.5 nM. Learn More
  11. PF-00562271

    Catalog No. A12580
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    FAK inhibitor
    PF-00562271 is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively. Learn More
  12. PF-04554878 (Defactinib)

    Catalog No. A11929
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    FAK inhibitor
    PF-04554878 is a novel FAK kinase inhibitor that decreases growth and induces apoptosis in pancreatic neuroendocrine tumor cells Learn More
  13. PF 573228

    Catalog No. A11235
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    FAK Inhibitor
    PF 573228 is a potent and selective inhibitor of focal adhesion kinase (FAK) (IC50 = 4 nM). Learn More
  14. PF-03814735

    Catalog No. A11171
    Aurora A/B Kinase inhibitor
    PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1. Learn More
  15. PF 431396

    Catalog No. A11142
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    FAK/PYK2 inhibitor
    PF 431396 is a dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively). Learn More
  16. PF-562271

    Catalog No. A11192
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    FAK inhibitor
    PF-562271 is an orally bioavailable small molecule and ATP-competitive focal adhesion kinase (FAK) inhibitor with potential antineoplastic and antiangiogenic activities. Learn More

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