Isocitrate Dehydrogenase (IDH)

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  1. Mutant IDH1-IN-1

    Catalog No. A21359
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    mutant-selective IDH1 inhibitor
    Mutant IDH1-IN-1 is a mutant-selective IDH1 inhibitor with with IC50s of 4, 42, 80 and 143 nM against mutant IDH1 R132C/R132C, IDH1 R132H/R132H, IDH1 R132H/WT and wild type IDH1, respectively. Learn More
  2. Mutant IDH1-IN-2

    Catalog No. A21339
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    IDH inhibitor
    Mutant IDH1-IN-2 is a inhibitor of mutant Isocitrate dehydrogenase (IDH) proteins, with IC50 of in LS-MS biochemical assay, IC50 of 16.6 nM in Fluorescence biochemical assay. Learn More
  3. Mutant IDH1 inhibitor

    Catalog No. A21150
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    mutant IDH1 R132H inhibitor
    Mutant IDH1 inhibitor is a potent mutant IDH1 R132H inhibitor with IC50 of < 72 nM. Learn More
  4. IDH1 Inhibitor 2

    Catalog No. A18420
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    IDH1 inhibitor
    DH1 Inhibitor 2 is a potent IDH1 inhibitor via a direct covalent modification of His315, with an IC50 of 110 nM. Learn More
  5. Mutant IDH1-IN-4

    Catalog No. A19106
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    IDH1 inhibitor
    Mutant IDH1-IN-4 (compound 434) is an inhibitor of mutant Isocitrate dehydrogenase 1 (IDH 1), with IC50 values of ?? 0.5 μM for mutant IDH1 in R132H, HT1080 and U87R132H cells. Learn More
  6. Olutasidenib (FT-2102)

    Catalog No. A18789
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    IDH1 inhibitor
    Olutasidenib is a potent, selective inhibitor of mutant Isocitrate dehydrogenase (IDH)1 for the treatment of acute myeloid leukemia. Learn More
  7. BAY-1436032

    Catalog No. A17059
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    mIDH1 inhibitor
    BAY-1436032 is a potent, selective and orally available inhibitor of mutant Isocitrate Dehydrogenase 1 (mIDH1). Learn More
  8. Vorasidenib

    Catalog No. A16908
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    IDH1 Inhibitor
    Vorasidenib, also known as AG-881, is a potent and selective orally available inhibitor of mutated forms of both isocitrate dehydrogenase type 1 (IDH1, IDH1 [NADP+] soluble) in the cytoplasm and type 2 (IDH2, isocitrate dehydrogenase [NADP+], mitochondrial) in the mitochondria, with potential antineoplastic activity. Learn More
  9. IDH-305

    Catalog No. A16943
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    IDH1 inhibitor
    IDH305 is an inhibitor of the citric acid cycle enzyme isocitrate dehydrogenase [NADP] cytoplasmic (isocitrate dehydrogenase 1; IDH1) with mutations at residue R132 (IDH1(R132)), with potential antineoplastic activity. Learn More
  10. AG-120 (Ivosidenib)

    Catalog No. A14386
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    IDH1 inhibitor
    AG-120 is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Learn More
  11. Enasidenib

    Catalog No. A15808
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    IDH2 inhibitor
    Enasidenib is a potent and selective IDH2 inhibitor with potential anticancer activity (IDH2 = Isocitrate dehydrogenase 2). Learn More
  12. IDH-C227

    Catalog No. A12923
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    IDH1 R132H inhibitor
    IDH-C227 is a potent and selective IDH1 R132H inhibitor. Learn More
  13. AGI-6780

    Catalog No. A12903
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    IDH2 R140Q inhibitor
    AGI-6780 is a potent, selective inhibitor of mutant IDH2 with an IC50 value of 23 nM. Learn More
  14. AGI-5198 (IDH-C35)

    Catalog No. A12902
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    IDH1 inhibitor
    AGI-5198, also know as IDH-C35, is the a very potent and selective mutant IDH1 inhibitor that was shown to potential anticancer activity. Learn More

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