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$0.00 TNF-α
| Catalog No. | Inhibitor Name | TNF-α | Other |
|---|---|---|---|
| A10743 | Pomalidomide | *** | |
| A11973 | Necrostatin-1 | * | |
| A12748 | QNZ | **** | NF-κB |
| A10924 | Thalidomide | ||
| A10522 | Lenalidomide (CC-5013) | *** |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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Lenalidomide (CC-5013)
Catalog No. A10522 Ubiquitin ligase inducerLenalidomide is a derivative of thalidomide. In vitro, lenalidomide has three main activities: direct anti-tumor effect, inhibition of the micro environment support for tumor cells, and immunomodulatory role. It induces tumor cell apoptosis directly and indirectly by inhibition of bone marrow stromal cell support, by anti-angiogenic and anti-osteoclastogenic effects, and by immunomodulatory activity. Learn More -
QNZ (EVP4593)
Catalog No. A12748 NF-κB inhibitorQNZ inhibits the activation of the transcription factor NF-κB and has been used to investigate NF-κB signaling. Learn More -
Pomalidomide (CC-4047)
Catalog No. A10743 TNF-alpha inhibitorPomalidomide is a derivative of thalidomide and acts as an immunomodulator. Learn More -
Necrostatin-1
Catalog No. A11973 RIPK1 inhibitorNecrostatin-1 is an ATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM). Learn More -
GW 4869
Catalog No. A11974 N-SMase inhibitorW4869 is a cell permeable, selective inhibitor of N-SMase (neutral sphingomyelinase). Learn More -
Necrostatin 2
Catalog No. A15183 Necroptosis inhibitorNecrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM. Learn More -
Necrostatin 2 racemate
Catalog No. A15327 Necroptosis inhibitorNecrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM. Learn More -
Necrostatin 2 S enantiomer
Catalog No. A15328 Necroptosis inhibitorNecrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM. Learn More -
Thalidomide
Catalog No. A10924 E3 ubiquitin ligase inhibitorThalidomide can directly inhibit angiogenesis induced by bFGF or VEGF in vivo. Learn More -
C 87
Catalog No. A12313 TNFα inhibitorC87 is a novel small-molecule TNFα inhibitor; potently inhibits TNFα-induced cytotoxicity with an IC50 of 8.73 μM. Learn More
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