TNF-α

Catalog No.Inhibitor Name TNF-αOther
A10743Pomalidomide
***
A11973Necrostatin-1
*
A12748QNZ
****
NF-κB
A10924Thalidomide
A10522Lenalidomide (CC-5013)
***

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. QNZ (EVP4593)

    Catalog No. A12748
    NF-κB inhibitor
    QNZ inhibits the activation of the transcription factor NF-κB and has been used to investigate NF-κB signaling. Learn More
  2. Pomalidomide (CC-4047)

    Catalog No. A10743
    TNF-alpha inhibitor
    Pomalidomide is a derivative of thalidomide and acts as an immunomodulator. Learn More
  3. Lenalidomide (CC-5013)

    Catalog No. A10522
    Ubiquitin ligase inducer
    Lenalidomide is a derivative of thalidomide. In vitro, lenalidomide has three main activities: direct anti-tumor effect, inhibition of the micro environment support for tumor cells, and immunomodulatory role. It induces tumor cell apoptosis directly and indirectly by inhibition of bone marrow stromal cell support, by anti-angiogenic and anti-osteoclastogenic effects, and by immunomodulatory activity. Learn More
  4. Necrostatin-1

    Catalog No. A11973
    RIPK1 inhibitor
    Necrostatin-1 is an ATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM). Learn More
  5. GW 4869

    Catalog No. A11974
    N-SMase inhibitor
    W4869 is a cell permeable, selective inhibitor of N-SMase (neutral sphingomyelinase). Learn More
  6. Necrostatin 2

    Catalog No. A15183
    Necroptosis inhibitor
    Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM. Learn More
  7. Necrostatin 2 racemate

    Catalog No. A15327
    Necroptosis inhibitor
    Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM. Learn More
  8. Necrostatin 2 S enantiomer

    Catalog No. A15328
    Necroptosis inhibitor
    Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM. Learn More
  9. Thalidomide

    Catalog No. A10924
    E3 ubiquitin ligase inhibitor
    Thalidomide can directly inhibit angiogenesis induced by bFGF or VEGF in vivo. Learn More

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