Natural Products

pseudohypericin have potent antiretroviral activity

Pseudolaric Acid A is a diterpene acid isolated from Pseudolarix kaempferi, has antifungal, cytotoxic and antifertile activities.

Pseudolaric Acid B, a natural diterpenoid compound isolated from the root and trunk bark of Pseudolaric kaempferi Gordon, has anti-fungal and anti-fertility properties.

Punicalagin is an ellagitannin, a type of phenolic compounds. It is a highly active carbonic anhydrase inhibitor.

Punicalin is a highly active carbonic anhydrase inhibitor.

Quercitrin is known as an bio flavonoid antioxidant and was investigated extensively in its antioxidant potential in streptrozotocin (STZ)-induced diabetic rats.

Rosavin is a well-known glycoside antioxidant from Rhadiola rosea (Golden Root, or Arctic Root) that exhibits antidepressant, anxiolytic and adaptogenic properties.

Rosiridin is a bio-active isolate of Rhodiola.

Sarsasapogenin is a steroidal sapogenin, that is the aglycosidic portion of a plant saponin. Sarsasapogenin and its C-25 epimer smilagenin lowered blood sugar and reversed diabetic weight gain in experiments within mice with a mutant diabetes gene (db).

Scutellarin is a flavonoid that exhibits a number of cardio- and neuro-protective effects.

Sesamolin is a lignan isolated from sesame oil. It is found that sesamolin inhibited lipid peroxidation in rat liver and kidney.

Stevioside is a reagent that exhibits transepithelial p-aminohippurate transport.

Swertiamarin has shown potential as antiatherogenic agent by inhibiting HMG-CoA reductase activity in high cholesterol fed rats.

Tectoridin, an isoflavone glycoside from the flower of Pueraria lobata, prevents acute ethanol-induced liver steatosis in mice.

Tectorigenin is an O-methylated isoflavone.

Tiliroside, a glycosidic flavonoid, ameliorates obesity-induced metabolic disorders via activation of adiponectin signaling followed by enhancement of fatty acid oxidation in liver and skeletal muscle in obese-diabetic mice.

Triptonide is a Triptolide analogue used in the preparation of cytotoxic fluorinated Triptolide.

Vitexicarpin, a flavonoid from the fruits of Vitex rotundifolia, inhibits mouse lymphocyte proliferation and growth of cell lines in vitro.

Vitexin demonstrates antioxidant activity in a DPPH bleaching assay (IC50 = 24.2uM) and also inhibits the activity of the carbohydrate-hydrolyzing enzyme α-glucosidase (IC50 = 244 uM).

Dihydroactinidiolide, existing in plant leaves and fruits, is a potent plant growth inhibitor, a regulator of gene expression and is responsible for photo acclimation in Arabidopsis.

Chelidonin inhibits tubulin polymerisation (IC50=24 uM), thereby disrupting microtubule structure in cells and inducing a G2/M mitotic arrest.

Grosvenorine is the major flavonoid compound of the fruits of Siraitia grosvenorii. Grosvenorine exhibits good antibacterial and antioxidant activities.

Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, inhibits NO release, with anti-fibrotic activity.

Mogroside III-A1, a triterpenoid glycoside isolated from the extracts of Luo Han Guo, is a nonsugar sweetener. Mogrosides are sweeter than sucrose. Mogrosides exhibit antioxidant, antidiabetic and anticancer activities.

Daurinoline is an alkaloid from the rhizomes of Menispermum canadense and Menispermum dauricum and from Phaeanthus vietnamensis.

Angelicin is a furanocoumarin typically isolated from the seeds of P. corylifolia. It has also been shown to prevent tacrine-induced cytotoxicity in human liver-derived HepG2 cells (EC50 = 47 ug/ml) and vascular relaxation in phenylephrine-precontracted rat aorta.

Cyanidin chloride is an anthocyanin polyphenolic antioxidant compound with demonstrated cell protectant effects.

Spinosin, a C-glycoside flavonoid from semen Zizhiphi Spinozae, potentiated pentobarbital-induced sleep via the serotonergic system.

Daurisoline alkaloid isolated from the rhizomes of Menispermum dauricum that exhibit varies pharmacological activities including antiplatelet aggregation, anti-inflammatory, neuron-protective properties, and antiarrhythmic effect.

Betulin is a triterpene with a pentacyclic ring structure and hydroxyl groups in positions C3 and C28. Betulin has protective effects against cadmium induced apoptosis in human hepatoma cell lines.

Pterostilbene is a stilbenoid chemically related to resveratrol and is found in blueberries and grapes. Antioxidant, antiproliferative, apoptosis inducer, antihyperglycemic, antidiabetic.

Wogonin is an anti-inflammatory agent and an inhibitor of CDK9 and does not inhibit CDK2, CDK4 and CDK6 at doses that inhibit CDK9 activity; Also inhibits N-acetyltransferase

Astragaloside II induces osteogenic activities of osteoblasts through the bone morphogenetic protein-2/MAPK and Smad1/5/8 pathways.

Astragaloside I, II, III, and IV concentration-dependently increased the CD45-mediated of pNPP/OMFP hydrolysis with the EC50 values ranged from 3.33 to 10.42 ug/mL.

Sinomenine hydrochloride enhancement of the inhibitory effects of anti-transferrin receptor antibody-dependent on the COX-2 pathway in human hepatoma cells.

Lobetyolin is isolated from the hairy roots of Lobelia inflata.

Scutellarin, a main active ingredient extracted from Erigeron breviscapus (Vant.) Hand-Mazz, has been wildly used to treat acute cerebral infarction and paralysis induced by cerebrovascular diseases.

Eugenin is a chromone isolated from Peucedanum japonicum, with potent antiplatelet aggregation activity.

Astragaloside IV is a constituent of Astragali radix.

Aucubin is an iridoid glycoside. Irioids decrease the growth rates of many generalist herbivores.

Halofuginone is a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities.

6-(γ,γ-Dimethylallylamino)purine is a plant growth substance.

Salvianolic Acid B is isolated and purified from the crude extract of Salvia miltiorrhiza.

Budesonide is a glucocorticoid steroid for the treatment of asthma and non-infectious rhinitis (including hay fever and other allergies), and for treatment and prevention of nasal polyposis. In addition, it is used for Crohn's disease (inflammatory bowel disease).

Manool is a labdane diterpenoid in which the labdane skeleton has double bonds at positions 8(17) and 14 and carries an R-hydroxy group at position 13. It has a role as an antineoplastic agent, a plant metabolite and an antibacterial agent. It is a labdane diterpenoid and a tertiary alcohol.

Procyanidin B3 is a B type proanthocyanidin. Procyanidin B3 is a catechin dimer. It can be found in barley, in beer, in peach or in Jatropha macrantha, the Huanarpo Macho. It has been identified as an hair-growth stimulant

Pladienolide B is the major analogue of a family of macrocyclic lactones isolated from Streptomyces platensis. Pladienolide B is a highly potent inhibitor of both hypoxia signals and cancer cell proliferation. Pladienolide B binds to SF3b complex blocking the spliceosome.

Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.

FR901464 is a potent anticancer natural product that lowers the mRNA levels of oncogenes and tumor suppressor genes.

Gimatecan is an orally bioavailable, semi-synthetic lipophilic analogue of camptothecin, a quinoline alkaloid extracted from the Asian tree Camptotheca acuminate, with potential antineoplastic and antiangiogenic activities.