AMPK

Catalog No.Inhibitor Name AMPK
A13720Dorsomorphin 2HCl
**
A14312WZ4003
****
A11970Dorsomorphin
**
A16281HTH-01-015
***
A11071A 769662
*
A15815ETC-1002

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Acadesine (Aicar,NSC 105823)

    Catalog No. A10028
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    AMPK activator

    Acadesine is a selective activator of AMPK in both hepatocytes and adipocytes.

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  2. IM156

    Catalog No. A22320
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    AMPK activator
    IM156 (HL156A), a metformin derivative, is a potent activator of AMPK that increases AMPK phosphorylation. Learn More
  3. ASP4132

    Catalog No. A22339
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    AMPK activator
    ASP4132 is an orally active, potent AMPK activator with an EC50 of 18 nM. ASP4132 has anti-cancer activity and makes tumor regression in breast cancer xenograft mouse models. Learn More
  4. PF-06679142

    Catalog No. A22484
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    AMPK activator
    PF-06679142 is a potent AMPK activator. PF-06679142 exhibited robust activation of AMPK in rat kidneys as well as desirable oral absorption, low plasma clearance, and negligible renal clearance in preclinical species. Learn More
  5. Metformin

    Catalog No. A11622
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    AMP-activated protein kinase (AMPK) activator
    Metformin is an AMP-activated protein kinase (AMPK) activator that improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. Learn More
  6. O-304

    Catalog No. A19807
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    AMPK activator
    O-304 is a first-in-class, orally available pan-AMPK activator, which increases AMPK activity by suppressing the dephosphorylation of pAMPK. Learn More
  7. ZLN024

    Catalog No. A21963
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    AMPK allosteric activator
    ZLN024 is an AMPK allosteric activator. Learn More
  8. MK8722

    Catalog No. A13392
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    pan-AMPK activator
    MK8722 is a potent and systemic pan-AMPK activator. Learn More
  9. ex229 (compound 991)

    Catalog No. A16795
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    AMPK activator
    EX229 (compound 991) is a potent AMPK activator that is 5-10-fold more potent than A769662 in activating AMPK. Learn More
  10. YLF-466D

    Catalog No. A16284
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    AMPK activator
    YLF-466D is an allosteric AMPK activator. Learn More
  11. GSK621

    Catalog No. A15896
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    AMPK activator
    GSK621 is a potent and selective AMPK agonist. Learn More
  12. ETC-1002

    Catalog No. A15815
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    ACL inhibitor and AMPK activator
    ETC-1002 is a novel, first-in-class, orally available, once-daily LDL-C lowering small molecule; activator of hepatic AMP-activated protein kinase (AMPK); also has potent inhibitory activity against hepatic ATP-citrate lyase(IC50=29 uM). Learn More
  13. Dorsomorphin 2HCl

    Catalog No. A13720
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    BMP inhibitor
    Dorsomorphin, also known as BML-275, is a selective small molecule inhibitor of BMP signaling, which promotes cardiomyogenesis in embryonic stem cells. Dorsomorphin reverses the mesenchymal phenotype of breast cancer initiating cells by inhibition of bone morphogenetic protein signaling. Learn More
  14. BML-275 (Dorsomorphin)

    Catalog No. A11970
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    AMPK inhibitor
    BML-275 is a cell-permeable pyrazolopyrimidine compound shown to be an AMP-activated protein kinase (AMPK) and fatty acid synthase inhibitor. Learn More
  15. A-769662

    Catalog No. A11071
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    AMPK activator
    A-769662 is a new activator of AMP-activated protein kinase (AMPK). Learn More
  16. PF-06409577

    Catalog No. A16801
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    AMPK activator
    PF-06409577 is orally bioavailable AMPK activator with EC50 of 7 nM for α1β1γ1 in the TR-FRET assay and it shows no detectable inhibition of hERG in a patch-clamp assay (100 μM) and was not an inhibitor (IC50 > 100 μM) of the microsomal activities of major human cytochrome P450 isoforms. Learn More
  17. HTH-01-015

    Catalog No. A16281
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    NUAK1 inhibitor
    HTH-01-015 is a potent and selective inhibitor of NUAK1 (IC50 = 100 nM) and does not affect the activity of a panel of 139 other kinases, including additional AMPK family members. Learn More
  18. MK-3903

    Catalog No. A17063
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    AMPK activator
    MK-3903 is a potent and selective AMPK activator (EC50 = 8 nM). MK-3903 exhibited robust target engagement in mouse liver following oral dosing, leading to improved lipid metabolism and insulin sensitization in mice. Learn More
  19. WZ4003

    Catalog No. A14312
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    NUAK kinase inhibitor
    WZ4003 is a highly specific NUAK kinase inhibitor with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2 Learn More
  20. Phenformin hydrochloride

    Catalog No. A10717
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    Phenformin hydrochloride is a hydrochloride salt of phenformin from the biguanide drug class that displays anti-diabetic activity. Learn More

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