Catalog No.Inhibitor Name AMPK
A13720Dorsomorphin 2HCl
A11071A 769662

1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. A-769662

    Catalog No. A11071
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    AMPK activator
    A-769662 is a new activator of AMP-activated protein kinase (AMPK). Learn More
  2. MK8722

    Catalog No. A13392
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    pan-AMPK activator
    MK8722 is a potent and systemic pan-AMPK activator. Learn More
  3. ex229 (compound 991)

    Catalog No. A16795
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    AMPK activator
    EX229 (compound 991) is a potent AMPK activator that is 5-10-fold more potent than A769662 in activating AMPK. Learn More
  4. YLF-466D

    Catalog No. A16284
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    AMPK activator
    YLF-466D is an allosteric AMPK activator. Learn More
  5. GSK621

    Catalog No. A15896
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    AMPK activator
    GSK621 is a potent and selective AMPK agonist. Learn More
  6. ETC-1002

    Catalog No. A15815
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    ACL inhibitor and AMPK activator
    ETC-1002 is a novel, first-in-class, orally available, once-daily LDL-C lowering small molecule; activator of hepatic AMP-activated protein kinase (AMPK); also has potent inhibitory activity against hepatic ATP-citrate lyase(IC50=29 uM). Learn More
  7. Dorsomorphin 2HCl

    Catalog No. A13720
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    BMP inhibitor
    Dorsomorphin, also known as BML-275, is a selective small molecule inhibitor of BMP signaling, which promotes cardiomyogenesis in embryonic stem cells. Dorsomorphin reverses the mesenchymal phenotype of breast cancer initiating cells by inhibition of bone morphogenetic protein signaling. Learn More
  8. BML-275 (Dorsomorphin)

    Catalog No. A11970
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    AMPK inhibitor
    BML-275 is a cell-permeable pyrazolopyrimidine compound shown to be an AMP-activated protein kinase (AMPK) and fatty acid synthase inhibitor. Learn More
  9. Acadesine (Aicar,NSC 105823)

    Catalog No. A10028
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    AMPK activator

    Acadesine is a selective activator of AMPK in both hepatocytes and adipocytes.

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  10. ZLN024

    Catalog No. A21963
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    AMPK allosteric activator
    ZLN024 is an AMPK allosteric activator. Learn More
  11. WZ4003

    Catalog No. A14312
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    NUAK kinase inhibitor
    WZ4003 is a highly specific NUAK kinase inhibitor with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2 Learn More
  12. HTH-01-015

    Catalog No. A16281
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    NUAK1 inhibitor
    HTH-01-015 is a potent and selective inhibitor of NUAK1 (IC50 = 100 nM) and does not affect the activity of a panel of 139 other kinases, including additional AMPK family members. Learn More
  13. Phenformin hydrochloride

    Catalog No. A10717
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    Phenformin hydrochloride is a hydrochloride salt of phenformin from the biguanide drug class that displays anti-diabetic activity. Learn More
  14. PF-06409577

    Catalog No. A16801
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    AMPK activator
    PF-06409577 is orally bioavailable AMPK activator with EC50 of 7 nM for α1β1γ1 in the TR-FRET assay and it shows no detectable inhibition of hERG in a patch-clamp assay (100 μM) and was not an inhibitor (IC50 > 100 μM) of the microsomal activities of major human cytochrome P450 isoforms. Learn More
  15. MK-3903

    Catalog No. A17063
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    AMPK activator
    MK-3903 is a potent and selective AMPK activator (EC50 = 8 nM). MK-3903 exhibited robust target engagement in mouse liver following oral dosing, leading to improved lipid metabolism and insulin sensitization in mice. Learn More

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