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$0.00 AMPK
| Catalog No. | Inhibitor Name | AMPK |
|---|---|---|
| A13720 | Dorsomorphin 2HCl | ** |
| A14312 | WZ4003 | **** |
| A11970 | Dorsomorphin | ** |
| A16281 | HTH-01-015 | *** |
| A11071 | A 769662 | * |
| A15815 | ETC-1002 |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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Acadesine (Aicar,NSC 105823)
Catalog No. A10028 AMPK activatorAcadesine is a selective activator of AMPK in both hepatocytes and adipocytes.
Learn More -
IM156
Catalog No. A22320 AMPK activatorIM156 (HL156A), a metformin derivative, is a potent activator of AMPK that increases AMPK phosphorylation. Learn More -
ASP4132
Catalog No. A22339 AMPK activatorASP4132 is an orally active, potent AMPK activator with an EC50 of 18 nM. ASP4132 has anti-cancer activity and makes tumor regression in breast cancer xenograft mouse models. Learn More -
PF-06679142
Catalog No. A22484 AMPK activatorPF-06679142 is a potent AMPK activator. PF-06679142 exhibited robust activation of AMPK in rat kidneys as well as desirable oral absorption, low plasma clearance, and negligible renal clearance in preclinical species. Learn More -
Metformin
Catalog No. A11622 AMP-activated protein kinase (AMPK) activatorMetformin is an AMP-activated protein kinase (AMPK) activator that improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. Learn More -
O-304
Catalog No. A19807 AMPK activatorO-304 is a first-in-class, orally available pan-AMPK activator, which increases AMPK activity by suppressing the dephosphorylation of pAMPK. Learn More -
ZLN024
Catalog No. A21963 -
MK8722
Catalog No. A13392 -
ex229 (compound 991)
Catalog No. A16795 AMPK activatorEX229 (compound 991) is a potent AMPK activator that is 5-10-fold more potent than A769662 in activating AMPK. Learn More -
YLF-466D
Catalog No. A16284 -
ETC-1002
Catalog No. A15815 ACL inhibitor and AMPK activatorETC-1002 is a novel, first-in-class, orally available, once-daily LDL-C lowering small molecule; activator of hepatic AMP-activated protein kinase (AMPK); also has potent inhibitory activity against hepatic ATP-citrate lyase(IC50=29 uM). Learn More -
Dorsomorphin 2HCl
Catalog No. A13720 BMP inhibitorDorsomorphin, also known as BML-275, is a selective small molecule inhibitor of BMP signaling, which promotes cardiomyogenesis in embryonic stem cells. Dorsomorphin reverses the mesenchymal phenotype of breast cancer initiating cells by inhibition of bone morphogenetic protein signaling. Learn More -
BML-275 (Dorsomorphin)
Catalog No. A11970 AMPK inhibitorBML-275 is a cell-permeable pyrazolopyrimidine compound shown to be an AMP-activated protein kinase (AMPK) and fatty acid synthase inhibitor. Learn More -
A-769662
Catalog No. A11071 AMPK activatorA-769662 is a new activator of AMP-activated protein kinase (AMPK). Learn More -
PF-06409577
Catalog No. A16801 AMPK activatorPF-06409577 is orally bioavailable AMPK activator with EC50 of 7 nM for α1β1γ1 in the TR-FRET assay and it shows no detectable inhibition of hERG in a patch-clamp assay (100 μM) and was not an inhibitor (IC50 > 100 μM) of the microsomal activities of major human cytochrome P450 isoforms. Learn More -
HTH-01-015
Catalog No. A16281 NUAK1 inhibitorHTH-01-015 is a potent and selective inhibitor of NUAK1 (IC50 = 100 nM) and does not affect the activity of a panel of 139 other kinases, including additional AMPK family members. Learn More -
MK-3903
Catalog No. A17063 AMPK activatorMK-3903 is a potent and selective AMPK activator (EC50 = 8 nM). MK-3903 exhibited robust target engagement in mouse liver following oral dosing, leading to improved lipid metabolism and insulin sensitization in mice. Learn More -
WZ4003
Catalog No. A14312 NUAK kinase inhibitorWZ4003 is a highly specific NUAK kinase inhibitor with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2 Learn More -
Phenformin hydrochloride
Catalog No. A10717 Phenformin hydrochloride is a hydrochloride salt of phenformin from the biguanide drug class that displays anti-diabetic activity. Learn More
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