Beta-secretase (BACE)

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  1. LY2886721

    Catalog No. A10543
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    BACE1 inhibitor
    LY2886721 is a novel potent agent that is used to treat Alzheimer's Disease in preclinical experiments. Learn More
  2. PF-06751979

    Catalog No. A20066
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    BACE1 inhibitor
    PF-06751979 is a potent, brain penetrant, β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 7.3 nM in BACE1 binding assay. Learn More
  3. BACE1-IN-4

    Catalog No. A18462
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    BACE1 inhibitor
    BACE1-IN-4 is a potent and highly selective BACE1 inhibitor, with an IC50 of 3.8 nM and a Ki of 1.9 nM, more selective at BACE1 over BACE2. Anti-Alzheimer's disease. Learn More
  4. Verubecestat (MK-8931)

    Catalog No. A16113
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    β-secretase/BACE1 inhibitor
    Verubecesta is a potent and selective beta-secretase inhibitor, and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor. Learn More
  5. Timosaponin b-II

    Catalog No. A14591
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    BACE1 Inhibitor
    Timosaponin B-II is a major active component of Anemarrhena asphodeloides Bunge (Liliaceae, rhizome) that has protective effects against cerebral ischaemic damage. Learn More
  6. AMG-8718

    Catalog No. A14407
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    BACE1 inhibitor
    AMG-8718 is a potent and orally efficacious BACE1 inhibitor. Learn More
  7. AZD5423

    Catalog No. A13249
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    nonsteroidal glucocorticoid receptor agonist
    AZD5423 is a novel nonsteroidal glucocorticoid receptor agonist. Learn More
  8. AZD3839

    Catalog No. A12825
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    BACE1 inhibitor
    AZD3839 is a potent and selective inhibitor of human BACE1 with Ki of 26.1 nM. Learn More
  9. LY2811376

    Catalog No. A11776
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    BACE1 inhibitor
    LY2811376 is the first orally available non-peptidic BACE1 inhibitor that produces profound Aβ-lowering effects in animals. Learn More
  10. Umibecestat (CNP520)

    Catalog No. A18987
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    BACE-1 inhibitor
    Umibecestat (CNP520) is a beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) inhibitor with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively. Learn More

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