Calcium Channels

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  1. GV-58

    Catalog No. A21966
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    N- and P/Q-type Ca2+ channels agonist
    GV-58 is a potent, selective N- and P/Q-type Ca2+ channels agonist with EC50 of 7.21/8.81 uM for N-type/P-Q-type Ca2+ channel; 20-fold less potent CDK inhibitor activity. Learn More
  2. JTV-519 free base

    Catalog No. A21846
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    Ca2+-dependent blocker
    TV-519 free base (K201 free base) is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties. Learn More
  3. TTA-Q6(isomer)

    Catalog No. A21724
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    T-type Ca2+ channel antagonist
    TTA-Q6(isomer) is an isomer of TTA-Q6. TTA-Q6 is a selective T-type Ca2+ channel antagonist. Learn More
  4. TTA-Q6

    Catalog No. A21360
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    T-type Ca2+ channel antagonist
    TTA-Q6 is a selective T-type Ca2+ channel antagonist, used in the neurological disease. Learn More
  5. (S)-(-)-Bay-K-8644

    Catalog No. A21164
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    L-type Ca2+ channel agonist
    (S)-(-)-Bay-K-8644 is an agonist of L-type Ca2+ channel. (S)-(-)-Bay-K-8644 activates Ba2+ currents (IBa) (EC50=32 nM). Learn More
  6. ABT-639 hydrochloride

    Catalog No. A12571
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    T-type Ca2+ channel blocker
    ABT-639 hydrochloride is a novel, peripherally acting, selective T-type Ca2+ channel blocker. Learn More
  7. Caldaret

    Catalog No. A13148
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    intracellular Ca2+ handling modulator
    Caldaret is an intracellular Ca2+ handling modulator that acts through reverse mode Na+/Ca2+ exchanger inhibition. Learn More
  8. Aranidipine

    Catalog No. A18291
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    Calcium channel antagonist
    Aranidipine (MPC1304) is a Ca2+ channel antagonist with potent and long-lasting antihypertensive effects. Learn More
  9. (S)-Amlodipine

    Catalog No. A14935
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    Calcium channel blocker
    (S)-Amlodipine is a (S)-Enantiomer of Amlodipine and a dihydropyridine calcium channel blocker with activity resides mainly in the (-)-isomer. Learn More
  10. NNC 55-0396

    Catalog No. A15188
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    Calcium channel blocker
    NNC 55-0396, Mibefradil derivative, is a highly selective T-type calcium channel blocker; displays IC50 values of 6.8 and > 100 μM for inhibition of Cav3.1 T-type channels and HVA currents respectively in INS-1 cells. Learn More
  11. NP118809

    Catalog No. A15192
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    N-type calcium channel blocker
    NP118809 is a potent N-type calcium channel blockers(IC50= 0.11 uM) ; good selectivity over L-type calcium channels. Learn More
  12. NS6180

    Catalog No. A12405
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    K(Ca) 3.1 channel blocker
    NS6180 is a novel potent and selective KCa3.1 channel inhibitor(IC50= 9 nM) prevents T-cell activation and inflammation. Learn More
  13. Bay K 8644

    Catalog No. A15875
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    Calcium Channel Activator
    Bay K 8644 is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM. Learn More
  14. Mibefradil dihydrochloride

    Catalog No. A12482
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    Calcium channel blocker
    Mibefradil 2Hcl is calcium channel blocker with moderate selectivity for T-type Ca2+ channels displaying IC50 values of 2.7 uM and 18.6 uM for T-type and L-type channels respectively. Learn More
  15. Dantrolene sodium Hemiheptahydrate

    Catalog No. A16146
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    Dantrolene sodium Hemiheptahydrate is a skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. Learn More
  16. YM-58483

    Catalog No. A16346
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    CRAC channel inhibitor
    YM-58483 is the first selective and potent inhibitor of CRAC channels and subsequent Ca2+ signals. Learn More
  17. Chlorocresol

    Catalog No. A16444
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    Chlorocresol is an activator of ryanodine receptor. Learn More
  18. Cinepazide maleate

    Catalog No. A16454
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    Cinepazide maleate is a maleate salt form of cinepazide which is a vasodilator. Learn More
  19. Cinnarizine

    Catalog No. A16455
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    calcium channel blocker
    Cinnarizine is a medication derivative of piperazine, and characterized as an antihistamine and a calcium channel blocker. Learn More
  20. Berbamine

    Catalog No. A14794
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    Calcium channel blocker
    Berbamine is a calcium channel blocker. Learn More
  21. ABT-639

    Catalog No. A12330
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    T-type Ca2+ channel blocker
    ABT-639 is a novel, peripherally acting, selective T-type Ca2+ channel blocker. Learn More
  22. Ca2+ channel agonist 1

    Catalog No. A12186
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    Ca2+ channel agonist/CDK2 inhibitor
    Ca2+ channel agonist 1 is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2, with EC50s of 14.23 μM and 3.34 μM, respectively, and is used as a potential treatment for motor nerve terminal dysfunction. Learn More
  23. Barnidipine

    Catalog No. A21940
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    L-type calcium antagonist
    Barnidipine (Mepirodipine) is an L-type calcium antagonist (CaA) with high affinity for [3H] initrendipine binding sites (Ki=0.21 nmol/l), has selective action against CaA receptors. Learn More
  24. Dantrolene sodium

    Catalog No. A17644
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    Calcium channel proteins inhibitor
    Dantrolene sodium is a inhibitor of calcium channel proteins, inhibiting the release of Ca2+ from the sarcoplasm. Dantrolene sodium is a skeletal muscle relaxant which acts by blocking muscle contraction beyond the neuromuscular junction. Learn More
  25. Clevidipine

    Catalog No. A11746
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    Calcium channel blocker
    Clevidipine is a dihydropyridine calcium channel blocker indicated for the reduction of blood pressure when oral therapy is not feasible or not desirable. Learn More
  26. Astragaloside A

    Catalog No. A11405
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    Ca2+ signaling modulator
    Astragaloside A is a novel regulator of HIF-1α and angiogenesis through the PI3K/Akt pathway in HUVECs that are exposed to hypoxia. Learn More
  27. CK-1827452 (Omecamtiv mecarbil)

    Catalog No. A11206
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    Myosin activator
    CK-1827452 is a selective cardiac specific myosin activator. Learn More
  28. Manidipine 2HCl

    Catalog No. A10554
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    Manidipine 2HCl is a HCl salt form of Manidipine which is a calcium channel blocker for Ca2+ current with IC50 of 2.6 nM. Learn More
  29. Amlodipine

    Catalog No. A10068
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    L-type calcium channel blocker
    Amlodipin is L-type calcium channel blocker that displays antihypertensive properties. It inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM) and displays vasoprotective effects in cardiovascular disease. Learn More
  30. Amlodipine besylate (Norvasc)

    Catalog No. A10069
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    L-type calcium channel blocker
    Amlodipine-besylate is L-type calcium channel blocker that displays antihypertensive properties. It inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM) and displays vasoprotective effects in cardiovascular disease. Learn More
  31. Cilnidipine

    Catalog No. A10215
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    Calcium channel blocker
    Cilnidipine is a dual blocker of L-type voltage-gated calcium channels in vascular smooth muscle and N-type calcium channels in sympathetic nerve terminals that supply. Learn More
  32. Isradipine

    Catalog No. A10487
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    calcium channel blocker
    Isradipine is a calcium channel blocker of the dihydropyridine class. Learn More
  33. Azelnidipine

    Catalog No. A11219
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    calcium channel blocker
    Azelnidipine is a calcium blocker that attenuates liver fibrosis and may increase antioxidant defence. that attenuates liver fibrosis and may increase antioxidant defence. Learn More
  34. Lacidipine

    Catalog No. A11729
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    Lacidipine is a calcium channel blocker Learn More
  35. Benidipine hydrochloride

    Catalog No. A11730
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    Benidipine hydrochloride is a long-acting T-type calcium channel blocker, on blood pressure and renal function in hypertensive patients with diabetes mellitus. Learn More
  36. Nilvadipine (ARC029)

    Catalog No. A11731
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    calcium channel blocker
    Nilvadipine is a calcium channel blocker (CCB) used for the treatment of hypertension and chronic major cerebral artery occlusion Learn More
  37. Tetrandrine (Fanchinine)

    Catalog No. A10921
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    Calcium Channel inhibitor
    Tetrandrine is a calcium channel blocker. It inhibits the degranulation of mast cells.Tetrandrine has anti-inflammatory and anti-fibrogenic actions, which make tetrandrine and related compounds potentially useful in the treatment of lung silicosis, liver cirrhosis, and rheumatoid arthritis. Learn More
  38. Diethylstilbestrol

    Catalog No. A10309
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    Diethylstilbestrol is a synthetic nonsteroidal estrogen that was first synthesized in 1938. It is also classified as an endocrine disruptor. Learn More
  39. Diltiazem HCl

    Catalog No. A10311
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    Diltiazem is a nondihydropyridine (non-DHP) member of the class of drugs known as calcium channel blockers, used in the treatment of hypertension, angina pectoris, and some types of arrhythmia. Learn More
  40. Manidipine (Manyper)

    Catalog No. A10553
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    Manidipine is a dihydropyridine compound and calcium channel protein inhibitor and antagonist. Learn More
  41. Pinaverium Bromide

    Catalog No. A12684
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    Pinaverium Bromide is a spasmolytic agent with low incidence of anticholinergic effects. Pinaverium Bromide is also an antispasmodic. Learn More
  42. Nifedipine

    Catalog No. A10643
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    L-type calcium channel blocker.
    Nifedipine is a L-type calcium channel blocker. Learn More
  43. Nimodipine

    Catalog No. A10645
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    Calcium Channel inhibitor
    Nimodipine is a L-type Ca2+ channel blocker. Learn More
  44. BAPTA tetrapotassium

    Catalog No. A13989
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    Selective calcium chelator
    BAPTA tetrapotassium is a selective calcium chelator with greater affinity for Ca2+ than Mg2+. Learn More
  45. BAPTA/AM

    Catalog No. A14023
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    Selective calcium chelator
    BAPTA/AM, an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures. Learn More
  46. Dantrolene

    Catalog No. A13928
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    Ca2+ release inhibitor
    Dantrolene sodium is a muscle relaxant that acts by abolishing excitation-contraction coupling in muscle cells, probably by action on the ryanodine receptor. Learn More
  47. Atagabalin

    Catalog No. A13402
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    Atagabalin is related to gabapentin, which similarly binds to the α2δ calcium channels (1 and 2). Learn More

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