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$0.00 JNK/c-Jun
| Catalog No. | Inhibitor Name | JNK1 | JNK2 | JNK3 | JNK | Other |
|---|---|---|---|---|---|---|
| A10860 | SP600125 | *** | *** | * | Aurora A,TrkA,FLT3 | |
| A12749 | JNK-IN-8 | **** | *** | **** | Kit (V559D,T670I),Kit (V559D),RIOK2 | |
| A11969 | JNK Inhibitor IX | * | ** | |||
| A11296 | AS 602801 (Bentamapimod) | ** | ** | * | ||
| A13564 | CC-930 ( Tanzisertib) | ** | *** | **** | ||
| A13565 | CEP-1347 | *** | ||||
| A13683 | BI-78D3 | * | ||||
| A11352 | CC-401 | |||||
| A15061 | DB07268 | **** | ||||
| A15136 | JNK-IN-7 | IRAK1, PIK3C3, PIP5K3 and PIP4K2C | ||||
| A16036 | IQ 3 | * | * | ** | NF-κB, AP1 | |
| A16039 | SU 3327 | * | ||||
| A16054 | TCS JNK 6o | **** | **** | ** | ||
| A16062 | IQ-1S | * | * | ** | ||
| A15883 | Vacquinol-1 |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
23 Item(s)
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AS 602801 (Bentamapimod)
Catalog No. A11296 JNK inhibitorAS 602801 is a novel, orally active, Jun Kinase Inhibitor. Learn More -
AS601245
Catalog No. A21502 cell-permeable JNK InhibitorAS601245 is a cell-permeable JNK Inhibitor with IC50s of 150, 220, and 70 nM for three JNK human isoforms (hJNK1, hJNK2, and hJNK3), respectively. Learn More -
DTP3
Catalog No. A16059 JNK inhibitorDTP3 is a selective GADD45β/MKK7 inhibitor, which inhibits cancer-selective NF-kB survival pathway. Learn More -
TCS JNK 6o
Catalog No. A16054 JNK inhibitorTCS JNK 6o is a ATP-competitive and selective c-Jun N-terminal kinase (JNK) inhibitor. Learn More -
JIP-1 (153-163)
Catalog No. A16041 JNK inhibitorJIP-1 (153-163) is a peptide inhibitor of c-Jun N-terminal kinase (JNK), based on residues 153-163 of JNK-interacting protein-1 (JIP-1). Binds to JNK with affinity in the micromolar range and minimally inhibits p38 and ERK. Learn More -
SU 3327
Catalog No. A16039 JNK inhibitorSU 3327 is a selective inhibitor of JNK (c-Jun N-terminal kinase)(IC50 = 0.7uM). SU 3327 is shown to inhibit the protein-protein interaction between JNK and JIP (IC50 = 239 nM). Learn More -
IQ 3
Catalog No. A16036 JNK3 inhibitorIQ 3 is a selective JNK3 inhibitor (Kd values are 66, 240 and 290 nM for JNK3, JNK1 and JNK2 respectively). Inhibits NF-kB/AP1 transcriptional activity in THP1-Blue cells (IC50 = 1.4 μM). Also inhibits TNF-α and IL-6 production in vitro. Learn More -
AEG 3482
Catalog No. A11281 JNK inhibitorAEG 3482 is a small-molecule inhibitor of Jun kinase (JNK)-dependent apoptosis. Learn More -
JNK-IN-7
Catalog No. A15136 JNK InhibitorJNK-IN-7 is a relatively selective JNKs inhibitor(IC50= 1.54/1.99/0.75 for JNK1/2/3); also bound to IRAK1, PIK3C3, PIP5K3 and PIP4K2C. Learn More -
DB07268
Catalog No. A15061 JNK1 inhibitorDB07268 is a potent and selective JNK1 inhibitor with an IC50 value of 9 nM. Learn More -
CC-401 hydrochloride
Catalog No. A15037 JNK inhibitorCC-401 hydrochloride is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity. Learn More -
CEP-1347
Catalog No. A13565 JNK inhibitorCEP-1347 is an inhibitor of c-jun N-terminal kinase (JNK) signaling. It rescues motor neurons undergoing apoptosis (EC50 = 20 nM). Learn More -
CC-930 (Tanzisertib)
Catalog No. A13564 JNK inhibitorCC-930 is kinetically competitive with ATP in the JNK-dependent phosphorylation of the protein substrate c-Jun and potent against all isoforms of JNK (Ki(JNK1) = 44 ± 3 nM, IC50(JNK1) = 61 nM, Ki(JNK2) = 6.2 ± 0.6 nM, IC50(JNK2) = 5 nM, IC50(JNK3) = 5 nM) and selective against MAP kinases ERK1 and p38a with IC50 of 0.48 and 3.4 μM respectively Learn More -
BI-78D3
Catalog No. A13683 JNK inhibitorBI-78D3 is a competitive JNK (c-Jun N-terminal kinases) inhibitor (IC50 = 280 nM) that displays > 100 fold selectivity over p38α and no activity at mTOR and PI-3K. BI 78D3 inhibits JIP1(JNK interacting protein 1)-JNK binding (IC50 = 500 nM). Learn More -
JNK-IN-8
Catalog No. A12749 JNK InhibitorJNK-IN-8 is the first irreversible JNK inhibitor for JNK1, JNK2 and JNK4 with IC50 of 4.7 nM, 18.7 nM and 1 nM, respectively Learn More -
CC-401
Catalog No. A11352 JNK inhibitorCC-401 is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity. Learn More -
SP600125
Catalog No. A10860 JNK inhibitorSP600125 is a JNK inhibitor with IC50=40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3. Learn More -
Vacquinol-1
Catalog No. A15883 MKK4-dependent macropinocytotic ActivatorVacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death. Learn More -
IQ-1S
Catalog No. A16062 JNK3 inhibitorIQ-1S is a Selective JNK3 inhibitor with IC50 value of 390, 360 and 87 nM for JNK1, 2 and 3 respectively. Learn More -
Anisomycin
Catalog No. A11271 SAPKs/JNKs activatorAnisomycin is a pyrrolidine antibiotic, acts as an anti-fungal antibiotic which inhibits Protein Synthesis, also is a potent activator of SAPKs/JNKs. Learn More -
SR 3576
Catalog No. A16020 JNK3 inhibitorSR 3576 is a highly potent and selective JNK3 inhibitor (IC50 = 7 nM); exhibits > 2800-fold selectivity over p38. Learn More -
c-JUN peptide
Catalog No. A16045 JNK inhibitorc-JUN peptide is a peptide comprising residues 33 - 57 of the JNK binding (δ) domain of human c-Jun. Learn More -
TCS JNK 5a
Catalog No. A11969 JNK Inhibitor IXTCS JNK 5a is a highly selective inhibitor of JNK2 and JNK3 (pIC50 values are 6.7, 6.5, <5.0 and <4.8 for JNK3, JNK2, JNK1 and p38?? respectively). Learn More
23 Item(s)
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