Protein Arginine Methyltransferases

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  1. C7280948

    Catalog No. A13876
    PRMT1 inhibitor
    C7280948 is an inhibitor of histone arginine methyltransferase PRMT1 with IC50 values of 12.75 uM. Learn More
  2. GSK-3326595 (EPZ015938)

    Catalog No. A16862
    PRMT5 inhibitor
    GSK3326595 is a potent, selective, reversible inhibitor of protein arginine methyltransferase 5 (PRMT5) with an IC50 of 6.2 nM. Learn More
  3. TC-E 5003

    Catalog No. A16378
    PRMT1 inhibitor
    TC-E 5003 is a selective inhibitor of PRMT1 with IC50 value of 1.5 uM . Learn More
  4. EPZ020411

    Catalog No. A16377
    PRMT6 inhibitor
    EPZ020411 is a potent and selective inhibitor of PRMT6 with IC50 of 10 nM, has >10 fold selectivity for PRMT6 over PRMT1 and PRMT8. Learn More
  5. HLCL-61

    Catalog No. A15870
    PRMT5 Inhibitor
    HLCL-61 hydrochloride is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia. Learn More
  6. AMI-1

    Catalog No. A15916
    Hmt1p/PRMT1 Inhibitor
    AMI-1 is a potent and specific Histone Methyltransferase (HMT) inhibitor with IC50 of 3.0 uM and 8.8 uM for yeast Hmt1p and human PRMT1, respectively. Learn More
  7. GSK591

    Catalog No. A14374
    PRMT5 inhibitor
    GSK591 is a potent selective inhibitor of the arginine methyltransferase PRMT5 with IC50 of 11 nM. Learn More
  8. MS023

    Catalog No. A12585
    PRMT1 inhibitor
    MS023 is a potent inihbitor of PRMTs 1,3,4,6,and 8 (IC50 = 30, 119, 83, 8, and 8 nM, respectively), which are responsible for asymmetric dimethylation of arginine residues. Learn More
  9. SGC 707

    Catalog No. A15450
    PRMT3 Inhibitor
    SGC 707 is a potent allosteric inhibitor of PRMT3 (IC50 = 50 nM) with >100-fold selectivity over other methyltransferases and other non-epigenetic targets. Learn More
  10. XY1

    Catalog No. A15807
    PRMT3 inhibitor
    XY1 is a negative control of SGC 707 . SGC 707 (Adooq Catalog# A15450) is a potent, selective allosteric inhibitor of PRMT3 (IC50 = 50 nM). Learn More
  11. PF-06855800

    Catalog No. A16860
    PRMT5 inhibitor
    PF-06855800 (PF06855800) is a potent, selective, SAM competitive, BBB-penetrant, orally active inhibitor of protein arginine methyltransferase PRMT5 with Ki of 0.02 nM. Learn More

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