Protein Arginine Methyltransferases

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  1. C7280948

    Catalog No. A13876
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    PRMT1 inhibitor
    C7280948 is an inhibitor of histone arginine methyltransferase PRMT1 with IC50 values of 12.75 uM. Learn More
  2. XY1

    Catalog No. A15807
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    PRMT3 inhibitor
    XY1 is a negative control of SGC 707 . SGC 707 (Adooq Catalog# A15450) is a potent, selective allosteric inhibitor of PRMT3 (IC50 = 50 nM). Learn More
  3. SGC 707

    Catalog No. A15450
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    PRMT3 Inhibitor
    SGC 707 is a potent allosteric inhibitor of PRMT3 (IC50 = 50 nM) with >100-fold selectivity over other methyltransferases and other non-epigenetic targets. Learn More
  4. MS023

    Catalog No. A12585
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    PRMT1 inhibitor
    MS023 is a potent inihbitor of PRMTs 1,3,4,6,and 8 (IC50 = 30, 119, 83, 8, and 8 nM, respectively), which are responsible for asymmetric dimethylation of arginine residues. Learn More
  5. GSK591

    Catalog No. A14374
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    PRMT5 inhibitor
    GSK591 is a potent selective inhibitor of the arginine methyltransferase PRMT5 with IC50 of 11 nM. Learn More
  6. AMI-1

    Catalog No. A15916
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    Hmt1p/PRMT1 Inhibitor
    AMI-1 is a potent and specific Histone Methyltransferase (HMT) inhibitor with IC50 of 3.0 uM and 8.8 uM for yeast Hmt1p and human PRMT1, respectively. Learn More
  7. HLCL-61

    Catalog No. A15870
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    PRMT5 Inhibitor
    HLCL-61 hydrochloride is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia. Learn More
  8. AMI5

    Catalog No. A16376
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    protein methyltransferase inhibitor
    AMI5 is a non-selective protein methyltransferase inhibitor. Learn More
  9. EPZ020411

    Catalog No. A16377
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    PRMT6 inhibitor
    EPZ020411 is a potent and selective inhibitor of PRMT6 with IC50 of 10 nM, has >10 fold selectivity for PRMT6 over PRMT1 and PRMT8. Learn More
  10. TC-E 5003

    Catalog No. A16378
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    PRMT1 inhibitor
    TC-E 5003 is a selective inhibitor of PRMT1 with IC50 value of 1.5 uM . Learn More
  11. GSK-3326595 (EPZ015938)

    Catalog No. A16862
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    PRMT5 inhibitor
    GSK3326595 is a potent, selective, reversible inhibitor of protein arginine methyltransferase 5 (PRMT5) with an IC50 of 6.2 nM. Learn More
  12. PF-06855800

    Catalog No. A16860
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    PRMT5 inhibitor
    PF-06855800 (PF06855800) is a potent, selective, SAM competitive, BBB-penetrant, orally active inhibitor of protein arginine methyltransferase PRMT5 with Ki of 0.02 nM. Learn More

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