Sirtuins

Catalog No.Inhibitor Name SIRT1SIRT2SIRT3SirtuinOther
A10377Selisistat (EX 527)
****
A12226Sirtinol
*
**
A15902SirReal2
****
A14221Splitomicin
**
A14225AGK2
***
A12305Tenovin-6
***
*
p53

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. SirReal2

    Catalog No. A15902
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    Selective SIRT2 inhibitor
    SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM. Learn More
  2. SRT 1720

    Catalog No. A15247
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  3. SRT1720 HCl

    Catalog No. A10862
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    SIRT1 Activator
    SRT1720 is an inhibitor developed intended as a small-molecule activator of the sirtuin subtype SIRT1. Learn More
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    MDL-800

    Catalog No. A17228
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    SIRT6 allosteric activator
    MDL-800 is a first-in-class cellularly active SIRT6 allosteric activator. Learn More
  4. CAY10602

    Catalog No. A19395
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    SIRT1 activator
    CAY10602 is a SIRT1 activator. Learn More
  5. SRT 1460

    Catalog No. A19026
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    SIRT1 activator
    SRT 1460, a potent Sirtuin-1 (SIRT1) activator with an EC1.5 value of 2.9 μM, shows good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 μM), and is more potent than Resveratrol and the closest sirtuin homologues. Learn More
  6. UBCS039

    Catalog No. A18961
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    SIRT6 activator
    UBCS039 is the first synthetic, specific Sirtuin 6 (SIRT6) activator, inducing autophagy in human tumor cells, with an EC50 of 38 μM. Learn More
  7. SRT 2183

    Catalog No. A12150
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    Sirtuin-1 (SIRT1) activator
    SRT 2183 is a selective Sirtuin-1 (SIRT1) activator with an EC1.5 value of 0.36 μM. SRT 2183 induces growth arrest and apoptosis, concomitant with deacetylation of STAT3 and NF-κB, and reduction of c-Myc protein levels. Learn More
  8. Cambinol

    Catalog No. A12381
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    SIRT1/SIRT2 inhibitor
    Cambinol is a SIRT1 and SIRT2 inhibitor with IC50 values of 56 and 59 μM, respectively. Learn More
  9. Salermide

    Catalog No. A12263
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    Sirt1/Sirt2 inhibitor
    Salermide is an inhibitor of Sirt1 and Sirt2; can cause strong cancer-specific apoptotic cell death. Learn More
  10. PROTAC Sirt2 Degrader-1

    Catalog No. A20005
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    Sirt2 degrader
    PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase. Learn More
  11. SRT 1720 Hydrochloride

    Catalog No. A21143
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    SIRT1 activator
    SRT 1720 Hydrochloride is a selective activator of SIRT1 with an EC50 of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3. Learn More
  12. SIRT-IN-2

    Catalog No. A20961
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    SIRT1/2/3 inhibitor
    SIRT-IN-2 is a potent inhibitor of SIRT1/2/3, with IC50s of 4, 4, 7 μM, respectively. Learn More
  13. 3-TYP

    Catalog No. A17144
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    SIRT3 inhibitor
    3-TYP is a SIRT3 inhibitor. Learn More
  14. Thiomyristoyl

    Catalog No. A17166
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    SIRT2 inhibitor
    Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. Learn More
  15. EX 527 (Selisistat)

    Catalog No. A10377
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    SIRT1 inhibitor
    EX 527 is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with IC50 of 38 nM in a cell-free assay. Learn More
  16. Fisetin (Fustel)

    Catalog No. A10388
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    Fisetin is a flavonol, a structurally distinct chemical substance that belongs to the flavonoid group of polyphenols. It can be found in many plants, where it serves as a colouring agent. Possible anti-aging, anti-inflammatory, anti-cancer, and anti-viral properties of fisetin are under active scientific investigation. Learn More
  17. AK-7

    Catalog No. A12904
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    SIRT2 inhibitor
    AK-7 is a cell- and brain-permeable inhibitor of SIRT2 (IC50 = 15.5 μM). Learn More
  18. Tenovin-6

    Catalog No. A12305
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    p53 activator
    Tenovin-6 is a analog of tenovin-1. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 values of 21, 10, and 67 uM, respectively. Learn More
  19. Inauhzin

    Catalog No. A12527
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    SIRT1 inhibitor
    Inauhzin is a potent SIRT inhibitor, which effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress. Learn More
  20. SRT2104 (GSK2245840)

    Catalog No. A14188
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    SIRT1 activator
    SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2. Learn More
  21. AGK2

    Catalog No. A14225
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    SIRT2 inhibitor
    AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM. Learn More
  22. AK-1

    Catalog No. A14370
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    SIRT2 inhibitor
    AK-1 inhibits SIRT2 selectively over SIRT1 and SIRT3. Learn More
  23. Sirtinol

    Catalog No. A12226
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    sirtuin inhibitor
    Sirtinol is a cell-permeable, specific inhibitor of sirtuin NAD-dependant histone deacetylases. It is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM in cell-free assays, respectively. Learn More
  24. OSS-128167

    Catalog No. A17048
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    SIRT 6 inhibitor
    OSS-128167, also known as SIRT6-IN-1, is a potent and selective SIRT 6 inhibitor with IC50 value of 89 μM. Learn More
  25. SIRT-IN-1

    Catalog No. A20962
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    SIRT1/2/3 inhibitor
    SIRT-IN-1 is a potent inhibitor of SIRT1/2/3, with IC50s of 15, 10, 33 μM, respectively. Learn More

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