Smoothened Receptors

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  1. LY2940680 (Taladegib)

    Catalog No. A11048
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    SMO Antagonist
    LY2940680 has been shown to affect a cancer cell signaling pathway initiated by the Hedgehog (Hh) protein. Learn More
  2. 20(S)-Hydroxycholesterol

    Catalog No. A21850
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    Smo allosteric activator
    20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog (Hh) signaling pathway with an EC50 of 3 μM in a gene transcription reporter assay using NIH3T3 cells. Learn More
  3. SAG hydrochloride

    Catalog No. A21678
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    Smo receptor agonist
    SAG (hydrochloride) is a potent Smo receptor agonist, and activates the Hedgehog signaling pathway, with a Kd of 59 nM. Learn More
  4. LEQ506

    Catalog No. A20941
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    Smo inhibitor
    LEQ506 is a second-generation inhibitor of smoothened (Smo) with IC50s of 2 and 4 nM in human and mouse, respectively. Learn More
  5. Saridegib

    Catalog No. A12966
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    Smo inhibitor
    Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway. Learn More
  6. ALLO-2

    Catalog No. A18698
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    Smo mutant antagonist
    ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM. Learn More
  7. Jervine

    Catalog No. A16221
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    SMO inhibitor
    Jervine is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog(Shh) signaling; Jervine is an inhibitor of Smo. Learn More
  8. SAG

    Catalog No. A13627
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    SMO agonist
    SAG is a chlorobenzothiophene-containing compound which acts as a SMO agonist (EC50 = 3 nM) but inhibits hedgehog signaling at high concentrations (>1 uM). Learn More
  9. PF-04449913

    Catalog No. A13881
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    Smoothened inhibitor
    PF-04449913 is a potent and orally bioavailable inhibitor of smoothened. Learn More
  10. BMS-833923 (XL-139)

    Catalog No. A13204
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    Smoothened inhibitor
    BMS-833923 (or XL-139) is an orally bioavailable small-molecule SMO (Smoothened) inhibitor with potential antineoplastic activity. Learn More
  11. PF-5274857

    Catalog No. A12775
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    Smoothened Inhibitor
    PF-5274857 is a novel Smo antagonist that specifically binds to Smo with a K(i) of 4.6 ± 1.1 nmol/L and completely blocks the transcriptional activity of the downstream gene Gli1 with an IC(50) of 2.7 ± 1.4 nmol/L in cells. Learn More
  12. LDE225 Diphosphate

    Catalog No. A12774
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    Smoothened Inhibitor
    LDE225 is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. Learn More
  13. MRT-83

    Catalog No. A21020
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    Smo antagonist
    MRT-83 is a potent antagonist of Smo, with an IC50 in the nanomolar range. MRT-83 also blocks Hedgehog (Hh) signaling. Learn More
  14. LDE225 (NVP-LDE225, Sonidegib)

    Catalog No. A10520
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    Smo Antagonist
    LDE225 (NVP-LDE225) is a potent, selective and orally bioavailable Smoothened (SMO) antagonist that inhibits hedgehog (Hh) signaling pathway via antagonism of the Smoothened receptor (SMO). Learn More

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