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$0.00 Smoothened Receptors
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LY2940680 (Taladegib)
Catalog No. A11048 SMO AntagonistLY2940680 has been shown to affect a cancer cell signaling pathway initiated by the Hedgehog (Hh) protein. Learn More -
LDE225 Diphosphate
Catalog No. A12774 Smoothened InhibitorLDE225 is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. Learn More -
PF-5274857
Catalog No. A12775 Smoothened InhibitorPF-5274857 is a novel Smo antagonist that specifically binds to Smo with a K(i) of 4.6 ± 1.1 nmol/L and completely blocks the transcriptional activity of the downstream gene Gli1 with an IC(50) of 2.7 ± 1.4 nmol/L in cells. Learn More -
BMS-833923 (XL-139)
Catalog No. A13204 Smoothened inhibitorBMS-833923 (or XL-139) is an orally bioavailable small-molecule SMO (Smoothened) inhibitor with potential antineoplastic activity. Learn More -
Glasdegib (PF-04449913)
Catalog No. A13881 Smoothened inhibitorPF-04449913 is a potent and orally bioavailable inhibitor of smoothened. Learn More -
SAG
Catalog No. A13627 SMO agonistSAG is a chlorobenzothiophene-containing compound which acts as a SMO agonist (EC50 = 3 nM) but inhibits hedgehog signaling at high concentrations (>1 uM). Learn More -
Jervine
Catalog No. A16221 SMO inhibitorJervine is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog(Shh) signaling; Jervine is an inhibitor of Smo. Learn More -
ALLO-2
Catalog No. A18698 Smo mutant antagonistALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM. Learn More -
Saridegib
Catalog No. A12966 Smo inhibitorSaridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway. Learn More -
LEQ506
Catalog No. A20941 Smo inhibitorLEQ506 is a second-generation inhibitor of smoothened (Smo) with IC50s of 2 and 4 nM in human and mouse, respectively. Learn More -
SAG hydrochloride
Catalog No. A21678 Smo receptor agonistSAG (hydrochloride) is a potent Smo receptor agonist, and activates the Hedgehog signaling pathway, with a Kd of 59 nM. Learn More -
20(S)-Hydroxycholesterol
Catalog No. A21850 Smo allosteric activator20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog (Hh) signaling pathway with an EC50 of 3 μM in a gene transcription reporter assay using NIH3T3 cells. Learn More -
MRT-83
Catalog No. A21020 Smo antagonistMRT-83 is a potent antagonist of Smo, with an IC50 in the nanomolar range. MRT-83 also blocks Hedgehog (Hh) signaling. Learn More -
LDE225 (NVP-LDE225, Sonidegib)
Catalog No. A10520 Smo AntagonistLDE225 (NVP-LDE225) is a potent, selective and orally bioavailable Smoothened (SMO) antagonist that inhibits hedgehog (Hh) signaling pathway via antagonism of the Smoothened receptor (SMO). Learn More
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