Sodium Channels



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Catalog No. Product Name Application Product Information
A10795 SALE

Riluzole (Rilutek)

-
Riluzole preferentially blocks TTX-sensitive sodium channels, which are associated with damaged neurons.This reduces influx of calcium ions and indirectly prevents stimulation of glutamate receptors.
A13943

Oxcarbazepine

sodium channel protein inhibitor
Oxcarbazepine is a sodium channel protein inhibitor.
A13898

Encainide HCl

Sodium channel blocker
Encainide HCl is a sodium channel blocker and class Ic antiarrhythmic. Encainide is a non-chiral antiarrhythmic and benzanilide derivative.
A13900

Disopyramide

Sodium channel blocker
Disopyramide is an antiarrhythmic (class IA) and a sodium channel blocker.
A13773 SALE

ICA-121431

NaV1.3 and NaV1.1 channels inhibitor
ICA-121431 is a potent and selective inhibitor of human NaV1.3 and NaV1.1 channels (IC50 values are 13 and 23 nM respectively).
A14011

Tenapanor

NHE3 inhibitor
Tenapanor acts as an inhibitor of the sodium-proton exchanger NHE3. This antiporter protein is found in the kidney and intestines, and normally acts to regulate the levels of sodium absorbed and secreted by the body.
A15088

Flecainide acetate

Cardiac Na+ channel blocker
Flecainide is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential.
A15228 SALE

S0859

NBC inhibitor
S0859, an N-cyanosulphonamide compound, reversibly inhibit NBC-mediated pH(i) recovery (K (i)=1.7 microM, full inhibition at approximately 30 microM).
A15243

Sodium Channel inhibitor 1

Sodium Channel inhibitor
Sodium Channel inhibitor 1, one of 3-Oxoisoindoline-1-carboxamides, is a novel and selective voltage-gated sodium channel for pain treatment.
A15275 SALE

Vernakalant HCl

Ion channel blocker
Vernakalant Hcl is an investigational mixed ion channel blocker that can terminate acute atrial fibrillation (AF) in humans at 2 to 5 mg/kg and may be more atrial-selective than available agents; in treatment of antiarrhythmic.
A15422

beta-Pompilidotoxin

Slows neuronal Na+ channel inactivation
beta-Pompilidotoxin is a peptide with the sequence H2N-Arg.
A14361

GS967

late INa Inhibitor
GS967 is a novel, potent, and selective inhibitor of cardiac late sodium current(late INa); inhibits ATX-II-induced late I(Na) in ventricular myocytes and isolated hearts with IC(50) values of 0.13 and 0.21 uM, respectively.
A15979

Levobupivacaine

sodium channel inhibitor
Levobupivacaine is a local anaesthetic drug belonging to the amino amide group.
A16130

Benzocaine hydrochloride

-
Benzocaine hydrochloride is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
A16131

Procaine

voltage-gated sodium channel inhibitor
Procaine is a benzoic acid derivative with local anesthetic and antiarrhythmic properties.
A16362

Pilsicainide HCl

Sodium Channel Blocker
Pilsicainide is a water soluble selective Na+ channel blocker.
A16365

PF-05089771

Nav1.7 Inhibitor
PF-05089771 is a Selective Nav1.7 Inhibitor (IC50 = 11 nM) that interacts with the voltage-sensor domain (VSD) of domain IV.
A14560

Benzocaine

-
Benzocaine is the ethyl ester of p-aminobenzoic acid (PABA), it is a local anesthetic commonly used as a topical pain reliever or in cough drops.
A14260

Chloroprocaine HCl

-
Chloroprocaine HCl is a local anesthetic during surgical procedures.
A14240

Procainamide HCl

Sodium channel blocker/DNMT inhibitor
Procainamide HCl is a sodium channel blocker, and also a DNA methyltransferase inhibitor.
A14242 SALE

Digoxin

sodium-potassium pump inhibitor
Digoxin is a sodium-potassium pump inhibitor.
A11234 SALE

A 803467

Sodium channel Blocker
A 803467 is a selective blocker of NaV1.8 channels (IC50 values are 8, 2450, 6740, 7340 and 7380 nM for hNaV1.8, hNaV1.3, hNaV1.7, hNaV1.5 and hNaV1.2 channels respectively).
A10510 SALE

Lacosamide

-
Lacosamide is a medication developed for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain.
A10064 SALE

Amiloride HCl

Na+ channel blocker
Amiloride hydrochloride is a Na+ channel blocker, also inhibits TRPP3 channels and Na+/H+ exchanger (NHE).
A10168 SALE

Bupivacaine HCl

-
Bupivacaine is a more potent inhibitor of cAMP production than are chemically related local anesthetics that are less prone to produce cardiovascular toxicity.
A11102

PF-04971729

SGLT2 inhibitor
PF-04971729 is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2.
A11712 SALE

Orphenadrine citrate

-
Orphenadrine is known to have the following pharmacology: mACh receptor antagonist (anticholinergic); H1 receptor antagonist (antihistamine); NMDA receptor antagonist; NET blocker (norepinephrine reuptake inhibitor); Nav1.7, Nav1.8, and Nav1.9 sodium channel blocker; HERG potassium channel blocker.
A11715 SALE

Proparacaine HCl

Voltage-gated sodium channels antagonist
Proparacaine HCl is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.
A11728 SALE

Amiloride hydrochloride dihydrate

-
Amiloride hydrochloride dihydrate is a potent epithelial sodium channel blocker and selective low threshold (T-type) calcium channel protein inhibitor (KD=30μM).
A11750 SALE

Ibutilide fumarate

-
Ibutilide is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm. It exerts its antiarrhythmic effect by induction of slow inward sodium current, which prolongs action potential and refractory period (physiology) of myocardial cells.
A10179 SALE

Carbamazepine

-
Carbamazepine is an anticonvulsant and mood-stabilizing drug used primarily in the treatment of epilepsy and bipolar disorder, as well as trigeminal neuralgia.
A10530 SALE

Lidocaine (Alphacaine)

-
Lidocaine (Alphacaine) is an anasthetic and class Ib antiarrhythmic agent. Blocks voltage-gated sodium channels in the inactivated state.
A10721 SALE

Phenytoin (Lepitoin)

-
Phenytoin is a sodium channel protein inhibitor.
A10722 SALE

Phenytoin sodium (Dilantin)

-
Phenytoin sodium (Dilantin) is a sodium channel protein inhibitor.
A11873 SALE

Lamotrigine

-
Lamotrigine is a novel anticonvulsant drug for inhibition of 5-HT with IC50 of 240 μM and 474 μM in human platelets and rat brain synaptosomes, and also is a sodium channel blocker.
A13760 SALE

QX 314 chloride

Sodium channel Blocker
QX 314 chloride is a membrane impermeable quaternary derivative of lidocaine, a voltage-activated Na+ channel blocker
A11602

Vinpocetine

PDE1 inhibitor
Vinpocetine is a Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
A14139

ENIPORIDE

Na(+)/H(+) exchange inhibitor
ENIPORIDE is a potent Na+/H+ exchange inhibitor.
A16398

Ambroxol HCl

Sodium Channel inhibitor
AmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 uM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM. Phase 3.

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