Sodium Channels

Actions
  1. Antagonist (1)
  2. Blocker (3)
  3. Inhibitor (2)


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Catalog No. Product Name Application Product Information
A11234

A 803467

Sodium channel Blocker
A 803467 is a selective blocker of NaV1.8 channels (IC50 values are 8, 2450, 6740, 7340 and 7380 nM for hNaV1.8, hNaV1.3, hNaV1.7, hNaV1.5 and hNaV1.2 channels respectively).
A10064

Amiloride HCl

Na+ channel blocker
Amiloride hydrochloride is a Na+ channel blocker, also inhibits TRPP3 channels and Na+/H+ exchanger (NHE).
A11728

Amiloride hydrochloride dihydrate

-
Amiloride hydrochloride dihydrate is a potent epithelial sodium channel blocker and selective low threshold (T-type) calcium channel protein inhibitor (KD=30μM).
A11750

Ibutilide fumarate

-
Ibutilide is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm. It exerts its antiarrhythmic effect by induction of slow inward sodium current, which prolongs action potential and refractory period (physiology) of myocardial cells.
A10510

Lacosamide

-
Lacosamide is a medication developed for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain.
A10530

Lidocaine (Alphacaine)

-
Lidocaine (Alphacaine) is an anasthetic and class Ib antiarrhythmic agent. Blocks voltage-gated sodium channels in the inactivated state.
A11102

PF-04971729

SGLT2 inhibitor
PF-04971729 is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2.
A10721

Phenytoin (Lepitoin)

-
Phenytoin is a sodium channel protein inhibitor.
A10722

Phenytoin sodium (Dilantin)

-
Phenytoin sodium (Dilantin) is a sodium channel protein inhibitor.
A11715

Proparacaine HCl

Voltage-gated sodium channels antagonist
Proparacaine HCl is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.
A13760

QX 314 chloride

Sodium channel Blocker
QX 314 chloride is a membrane impermeable quaternary derivative of lidocaine, a voltage-activated Na+ channel blocker
A10795

Riluzole (Rilutek)

-
Riluzole preferentially blocks TTX-sensitive sodium channels, which are associated with damaged neurons.This reduces influx of calcium ions and indirectly prevents stimulation of glutamate receptors.
A11602

Vinpocetine

PDE1 inhibitor
Vinpocetine is a Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.

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