CFTR

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  1. PTC124 (Ataluren)

    Catalog No. A10758
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    CFTR inhibitor
    PTC124 also known as Ataluren is CFTR-G542X nonsense allele inhibitor. Learn More
  2. PPQ-102

    Catalog No. A13000
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    CFTR chloride channel inhibitor
    PPQ-102 is a compound that targets intracellular nucleotide binding domain(s) of CFTR and inhibits CFTR- mediated chloride current in a voltage-dependent and reversible manner. Learn More
  3. CFTR-Inhibitor-II

    Catalog No. A13723
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    CFTR inhibitor
    CFTR inhibitor II, also known as GlyH-101, is a glycine hydrazide that selectively and reversibly blocks the CFTR channel (Ki = 4.3 uM). Learn More
  4. IOWH032

    Catalog No. A13511
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    CFTR inhibitor
    IOWH032 is a CFTR inhibitor. Learn More
  5. VX-661

    Catalog No. A12519
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    CFTR corrector
    VX-661 is another cystic fibrosis transmembrane conductance regulator (CFTR) corrector in development for the treatment of cystic fibrosis. Learn More
  6. VX-809 (Lumacaftor)

    Catalog No. A10986
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    CFTR modulator
    VX-809 is the second investigational oral candidate compound for the treatment of cystic fibrosis (CF). Learn More
  7. VX-770 (Ivacaftor)

    Catalog No. A10985
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    CFTR activator
    VX-770 (Ivacaftor) is known as a CFTR potentiator. Learn More
  8. Oridonin (Isodonol)

    Catalog No. A10675
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    CFTR Inhibitor
    Oridonin (Isodonol), an entkaurane diterpenoid isolated from Rabdosia rubescens, is an important traditional Chinese herbal remedy. Learn More
  9. CFTRinh-172

    Catalog No. A12897
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    CFTR inhibitor
    CFTRinh-172 is a voltage-independent, selective CFTR inhibitor Learn More
  10. KM 11060

    Catalog No. A15843
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    F508del-CFTR trafficking corrector
    KM 11060 corrects F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma membrane (~75%) and Inhibits PDE5 activity Learn More

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