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PTC124 (Ataluren)
Catalog No. A10758 CFTR inhibitorPTC124 also known as Ataluren is CFTR-G542X nonsense allele inhibitor. Learn More -
VX-770 (Ivacaftor)
Catalog No. A10985 CFTR activatorVX-770 (Ivacaftor) is known as a CFTR potentiator. Learn More -
VX-809 (Lumacaftor)
Catalog No. A10986 CFTR modulatorVX-809 is the second investigational oral candidate compound for the treatment of cystic fibrosis (CF). Learn More -
VX-661
Catalog No. A12519 CFTR correctorVX-661 is another cystic fibrosis transmembrane conductance regulator (CFTR) corrector in development for the treatment of cystic fibrosis. Learn More -
Glyburide
Catalog No. A10433 -
CFTR-Inhibitor-II
Catalog No. A13723 CFTR inhibitorCFTR inhibitor II, also known as GlyH-101, is a glycine hydrazide that selectively and reversibly blocks the CFTR channel (Ki = 4.3 uM). Learn More -
PPQ-102
Catalog No. A13000 CFTR chloride channel inhibitorPPQ-102 is a compound that targets intracellular nucleotide binding domain(s) of CFTR and inhibits CFTR- mediated chloride current in a voltage-dependent and reversible manner. Learn More -
Oridonin (Isodonol)
Catalog No. A10675 CFTR InhibitorOridonin (Isodonol), an entkaurane diterpenoid isolated from Rabdosia rubescens, is an important traditional Chinese herbal remedy. Learn More -
CFTRinh-172
Catalog No. A12897 CFTR inhibitorCFTRinh-172 is a voltage-independent, selective CFTR inhibitor Learn More -
KM 11060
Catalog No. A15843 F508del-CFTR trafficking correctorKM 11060 corrects F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma membrane (~75%) and Inhibits PDE5 activity Learn More -
PG 01
Catalog No. A18315 CFTR potentiatorPG 01 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. PG 01 is effective on G970R although with a significant decrease in potency relative to E193K and δF508. Learn More -
CFTR corrector 2
Catalog No. A18528 CFTR correctorCFTR corrector 2 is a cystic fibrosis transmembrane conductance corrector (CFTR), extracted from patent US20140274933. Learn More -
GLPG2451
Catalog No. A18919 CFTR potentiatorGLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC50 of 11.1 nM. Learn More -
Ivacaftor benzenesulfonate
Catalog No. A15132 CFTR potentiatorIvacaftor benzenesulfonate is an orally bioavailable CFTR potentiator, used for cystic fibrosis treatment. Learn More -
Ivacaftor hydrate
Catalog No. A15133 CFTR potentiatorIvacaftor hydrate is an orally bioavailable CFTR potentiator, used for cystic fibrosis treatment. Learn More
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