DPP-4

Catalog No.Inhibitor Name DPP-4
A10848Sitagliptin phosphate monohydrate
**
A11224Linagliptin
****
A12528Vildagliptin (LAF-237)
***
A11109Saxagliptin
*
A13571Alogliptin
***
A14293Trelagliptin

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Teneligliptin

    Catalog No. A15505
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    DPP-4 inhibitor
    Teneligliptin is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 values of approximately 1 nM. Learn More
  2. NVP DPP 728 dihydrochloride

    Catalog No. A15320
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    DPP-4 inhibitor
    NVP DPP 728 dihydrochloride is a potent and orally active inhibitor of dipeptidyl peptidase (DPP)-IV with Ki and IC50 values of 11 nM and 14 nM, respectively. Learn More
  3. PK 44 phosphate

    Catalog No. A15309
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    DPP-4 inhibitor
    PK 44 phosphate is a potent inhibitor of dipeptidyl peptidase IV (DPP-IV) with an IC50 value of 15.8 nM. Learn More
  4. DPPI 1c hydrochloride

    Catalog No. A15298
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    DPP-4 inhibitor
    DPPI 1c hydrochloride is a dicyanopyrrolidine compound that acts as a slow-binding and active site-targeting inhibitor of CD26 (DPP 4), with an IC50 = 106 nM and little activity against DPP II, DPP III, DPP VIII, DPP IX, FAP, or APP even at concentrations as high as 30 μM. Learn More
  5. Teneligliptin hydrobromide

    Catalog No. A15258
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    DPP-4 inhibitor
    Teneligliptin is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 values of approximately 1 nM. Learn More
  6. Saxagliptin (BMS-477118)

    Catalog No. A11109
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    DPP-4 Inhibitor
    Saxagliptin (BMS-477118) is a new dipeptidyl peptidase-4 (DPP-4) inhibitor with IC50 of 50 nM. Learn More
  7. UAMC 00039 dihydrochloride

    Catalog No. A16047
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    DPP-II inhibitor
    UAMC 00039 dihydrochloride is a potent inhibitor of dipeptidyl peptidase II (DPP-II) (IC50 = 0.48 nM). Exhibits selectivity for DPP-II against DPP-9, DPP-8 and DPP-IV (IC50 values are 78.6, 142 and 165 μM, respectively). Learn More
  8. Anagliptin

    Catalog No. A13529
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    DPP-4 inhibitor
    Anagliptin is a potent and selective DPP-4 inhibitor(IC50= 3.8 nM); > 10 fold less potent for DPP-8 and DPP-9. Learn More
  9. Alogliptin

    Catalog No. A13571
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    DPP-4 inhibitor
    Alogliptin is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. Learn More
  10. Sitagliptin

    Catalog No. A14377
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    DDP-4 inhibitor
    Sitagliptin is an oral antihyperglycemic (anti-diabetic drug) of the dipeptidyl peptidase-4 (DPP-4) inhibitor class. Learn More
  11. Trelagliptin

    Catalog No. A14293
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    DPP-4 inhibitor
    Trelagliptin is a highly selective, long-acting DPP-4 inhibitor. Learn More
  12. Trelagliptin Succinate (SYR-472)

    Catalog No. A13312
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    DPP-4 inhibitor
    Trelagliptin is a long acting dipeptidyl peptidase-4 (DPP-4) inhibitor that is being developed for the treatment of type 2 diabetes (T2D). Learn More
  13. Alogliptin Benzoate

    Catalog No. A13311
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    DPP-4 inhibitor
    Alogliptin Benzoate is a dipeptidyl-peptidase-4 (DPP 4) inhibitor Learn More
  14. MK-3102

    Catalog No. A13310
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    DPP-4 inhibitor
  15. Vildagliptin

    Catalog No. A12528
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    DPP-IV Inhibitor
    Vildagliptin is a dipeptidyl peptidase-4 (CD26) inhibitor. Learn More
  16. Linagliptin (BI-1356)

    Catalog No. A11224
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    DPP-4 Inhibitor
    Linagliptin is a DPP-4 inhibitor, an enzyme that degrades the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Learn More
  17. Sitagliptin phosphate monohydrate

    Catalog No. A10848
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    DDP-4 inhibitor
    Sitagliptin phosphate is an anti-diabetic (antihyperglycemic) drug of the dipeptidyl peptidase-4 (DPP-4) class. Inhibition of the enzyme DPP-4 is thought to increase Glucagon-like peptide-1 (GLP-1) which inhibits glucagon release , stimulates the insulin release and lowers blood glucose. Learn More
  18. Talabostat mesylate

    Catalog No. A14080
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    DPP-4 inhibitor
    Talabostat mesylate is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM. Learn More

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