DPP-4

Catalog No.Inhibitor Name DPP-4
A10848Sitagliptin phosphate monohydrate
**
A11224Linagliptin
****
A12528Vildagliptin (LAF-237)
***
A11109Saxagliptin
*
A13571Alogliptin
***
A14293Trelagliptin

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Vildagliptin dihydrate

    Catalog No. A21898
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    DPP4 inhibitor
    Vildagliptin (LAF237 dihydrate;NVP-LAF 237 dihydrate) is a dipeptidyl peptidase 4 (DPP4) inhibitor that delays the degradation of glucagon-like peptide-1 (GLP-1). Learn More
  2. Teneligliptin

    Catalog No. A15505
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    DPP-4 inhibitor
    Teneligliptin is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 values of approximately 1 nM. Learn More
  3. AZD7986

    Catalog No. A17095
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    DPPI inhibitor
    AZD7986, also known as INS 1007, is a second generation reversible covalent, potent and selective DPP1 inhibitor potentially for the treatment of chronic obstructive pulmonary disease (COPD) with predicted human PK properties suitable for once daily human dosing. Learn More
  4. 1G244

    Catalog No. A18709
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    DPP8/9 inhibitor
    1G244 is a novel potent and selective DPP8/9 inhibitor. Learn More
  5. Talabostat

    Catalog No. A14079
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    DPP-IV inhibitor
    Talabostat (Val-boroPro; PT100) is an orally active and nonselective dipeptidyl peptidase IV (DPP-IV) inhibitor (IC50 < 4 nM; Ki = 0.18 nM) and the first clinical inhibitor of fibroblast activation protein (FAP) (IC50 = 560 nM). Learn More
  6. Saxagliptin hydrate

    Catalog No. A16694
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    DPP4 inhibitor
    Saxagliptin H2O(BMS477118 H2O) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM and Ki of 1.3 nM. Learn More
  7. Gemigliptin

    Catalog No. A21285
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    DPP4 inhibitor
    Gemigliptin is a highly selective dipeptidyl peptidase 4 (DPP4) inhibitor with a KD of 7.25 nM. Learn More
  8. Teneligliptin hydrobromide hydrate

    Catalog No. A21465
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    DPP-4 inhibitor
    Teneligliptin hydrobromide hydrate is a potent chemotype prolylthiazolidine-based DPP-4 inhibitor, which competitively inhibits human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50s of approximately 1 nM. Learn More
  9. Diprotin A TFA

    Catalog No. A21475
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    DPP IV inhibitor
    Diprotin A (TFA) is an inhibitor of dipeptidyl peptidase IV (DPP-IV). Learn More
  10. Gosogliptin

    Catalog No. A21566
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    DPP-IV inhibitor
    Gosogliptin is a potent and selective inhibitor of dipeptidyl peptidase-IV (DPP-IV). Learn More
  11. Dutogliptin

    Catalog No. A21573
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    DPP4 inhibitor
    Dutogliptin (PHX-1149 free base) is an orally available, potent, and selective dipeptidyl peptidase-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus. Learn More
  12. DBPR108

    Catalog No. A21833
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    DPP4 inhibitor
    DBPR108 is a potent, selective, and orally bioavailable dipeptide-derived inhibitor of DPP4 with IC50 of 15 nM; no inhibition on DDP8 and DPP9. Learn More
  13. NVP DPP 728 dihydrochloride

    Catalog No. A15320
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    DPP-4 inhibitor
    NVP DPP 728 dihydrochloride is a potent and orally active inhibitor of dipeptidyl peptidase (DPP)-IV with Ki and IC50 values of 11 nM and 14 nM, respectively. Learn More
  14. PK 44 phosphate

    Catalog No. A15309
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    DPP-4 inhibitor
    PK 44 phosphate is a potent inhibitor of dipeptidyl peptidase IV (DPP-IV) with an IC50 value of 15.8 nM. Learn More
  15. DPPI 1c hydrochloride

    Catalog No. A15298
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    DPP-4 inhibitor
    DPPI 1c hydrochloride is a dicyanopyrrolidine compound that acts as a slow-binding and active site-targeting inhibitor of CD26 (DPP 4), with an IC50 = 106 nM and little activity against DPP II, DPP III, DPP VIII, DPP IX, FAP, or APP even at concentrations as high as 30 μM. Learn More
  16. Teneligliptin hydrobromide

    Catalog No. A15258
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    DPP-4 inhibitor
    Teneligliptin is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 values of approximately 1 nM. Learn More
  17. Sitagliptin phosphate monohydrate

    Catalog No. A10848
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    DDP-4 inhibitor
    Sitagliptin phosphate is an anti-diabetic (antihyperglycemic) drug of the dipeptidyl peptidase-4 (DPP-4) class. Inhibition of the enzyme DPP-4 is thought to increase Glucagon-like peptide-1 (GLP-1) which inhibits glucagon release , stimulates the insulin release and lowers blood glucose. Learn More
  18. Linagliptin (BI-1356)

    Catalog No. A11224
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    DPP-4 Inhibitor
    Linagliptin is a DPP-4 inhibitor, an enzyme that degrades the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Learn More
  19. Vildagliptin

    Catalog No. A12528
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    DPP-IV Inhibitor
    Vildagliptin is a dipeptidyl peptidase-4 (CD26) inhibitor. Learn More
  20. MK-3102

    Catalog No. A13310
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    DPP-4 inhibitor
    Omarigliptin (MK-3102) is a competitive, reversible inhibitor of DPP-4 (IC50 = 1.6 nM, Ki = 0.8 nM). It is highly selective over all proteases tested (IC50 > 67 μM), including QPP, FAP, PEP, DPP8, and DPP9 and has weak ion channel activity (IC50 > 30 μM at IKr, Caγ1.2, and Naγ1.5). Learn More
  21. Alogliptin Benzoate

    Catalog No. A13311
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    DPP-4 inhibitor
    Alogliptin Benzoate is a dipeptidyl-peptidase-4 (DPP 4) inhibitor Learn More
  22. Trelagliptin Succinate (SYR-472)

    Catalog No. A13312
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    DPP-4 inhibitor
    Trelagliptin is a long acting dipeptidyl peptidase-4 (DPP-4) inhibitor that is being developed for the treatment of type 2 diabetes (T2D). Learn More
  23. Trelagliptin

    Catalog No. A14293
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    DPP-4 inhibitor
    Trelagliptin is a highly selective, long-acting DPP-4 inhibitor. Learn More
  24. Sitagliptin

    Catalog No. A14377
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    DDP-4 inhibitor
    Sitagliptin is an oral antihyperglycemic (anti-diabetic drug) of the dipeptidyl peptidase-4 (DPP-4) inhibitor class. Learn More
  25. Alogliptin

    Catalog No. A13571
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    DPP-4 inhibitor
    Alogliptin is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. Learn More
  26. Anagliptin

    Catalog No. A13529
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    DPP-4 inhibitor
    Anagliptin is a potent and selective DPP-4 inhibitor(IC50= 3.8 nM); > 10 fold less potent for DPP-8 and DPP-9. Learn More
  27. Talabostat mesylate

    Catalog No. A14080
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    DPP-4 inhibitor
    Talabostat mesylate is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM. Learn More
  28. UAMC 00039 dihydrochloride

    Catalog No. A16047
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    DPP-II inhibitor
    UAMC 00039 dihydrochloride is a potent inhibitor of dipeptidyl peptidase II (DPP-II) (IC50 = 0.48 nM). Exhibits selectivity for DPP-II against DPP-9, DPP-8 and DPP-IV (IC50 values are 78.6, 142 and 165 μM, respectively). Learn More
  29. Saxagliptin (BMS-477118)

    Catalog No. A11109
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    DPP-4 Inhibitor
    Saxagliptin (BMS-477118) is a new dipeptidyl peptidase-4 (DPP-4) inhibitor with IC50 of 50 nM. Learn More

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