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Pim
Inhibitory Selectivity
| Catalog No. | Inhibitor Name | Pim1 | Pim2 | Pim3 | Other |
|---|---|---|---|---|---|
| A10838 | SGI-1776 free base | *** | * | * | FLT3 |
| A11945 | SMI-4a | ** | |||
| A14275 | CX-6258 HCl | *** | ** | ** | |
| A13203 | AZD1208 | **** | *** | **** | |
| A11967 | TCS PIM-1 4a | ** | * | ||
| A12896 | CX-6258 | *** | ** | ** | |
| A15368 | PIM-1 Inhibitor 2 | * | |||
| A15369 | TCS PIM-1 1 | * |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
10 Item(s)
per page
| Catalog No. | Product Name | Application | Product Information |
|---|---|---|---|
A10838 SALE |
SGI-1776 (free base) |
PIM1 Inhibitor |
SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. Phase 1.
|
A15368 |
PIM-1 Inhibitor 2
|
PIM-1 Inhibitor |
PIM-1 inhibitor 2 is a potent Pim-1 kinase inhibitor (Ki = 91 nM).
|
A15055 |
CX-6258 hydrochloride hydrate |
Pim Inhibitor |
CX-6258 hydrochloride hydrate is a potent, orally efficacious Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor with excellent biochemical potency and kinase selectivity.
|
A14420 |
LGB-321 HCl |
Pan-PIM kinase inhibitor |
LGB-321 HCl is a potent and selective ATP-competitive small molecule inhibitor of PIM kinases (Pan-PIM kinase inhibitor).
|
A14275 |
CX-6258 HCl |
Pan-PIM kinase inhibitor |
CX-6258 HCl is a potent, orally efficacious pan-Pim kinase inhibitor with IC50 of 5 nM, 25 nM and 16 nM for Pim1, Pim2, and Pim3.
|
A12896 |
CX-6258 |
Pim Inhibitor |
CX-6258 is a potent, selective, and orally efficacious pan-Pim kinases inhibitor.
|
A11967 |
TCS PIM-1 4a |
Pim inhibitor |
TCS PIM-1 4a is a selective and ATP-competitive Pim kinase inhibitor (IC50 values = 24 and 100 nM for Pim-1 and Pim-2, respectively).
|
A13203 SALE |
AZD1208 |
pan-Pim kinase inhibitor |
AZD1208 is orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity.
|
A11945 SALE |
SMI-4a |
Pim Inhibitor |
SIM-4a is a Pim kinase inhibitor that blocks mTORC1 activity via activation of AMPK. Mostly potent to Pim-2, does not significantly inhibit any other serine/threonine- or tyrosine-kinases.
|
A15369 SALE |
TCS PIM-1 1 |
Pim-1 Kinase Inhibitor |
TCS PIM-1 1 is a potent and selective ATP-competitive Pim-1 kianse inhibitor with IC50 of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2(IC50s >20,000 nM).
|
10 Item(s)
per page
