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| Catalog No. | Inhibitor Name | Pim1 | Pim2 | Pim3 | Other |
|---|---|---|---|---|---|
| A10838 | SGI-1776 free base | *** | * | * | FLT3 |
| A11945 | SMI-4a | ** | |||
| A14275 | CX-6258 HCl | *** | ** | ** | |
| A13203 | AZD1208 | **** | *** | **** | |
| A11967 | TCS PIM-1 4a | ** | * | ||
| A12896 | CX-6258 | *** | ** | ** | |
| A15368 | PIM-1 Inhibitor 2 | * | |||
| A15369 | TCS PIM-1 1 | * |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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SGI-1776 (free base)
Catalog No. A10838 PIM1 InhibitorSGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. Phase 1. Learn More -
TCS PIM-1 1
Catalog No. A15369 Pim-1 Kinase InhibitorTCS PIM-1 1 is a potent and selective ATP-competitive Pim-1 kianse inhibitor with IC50 of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2(IC50s >20,000 nM). Learn More -
PIM-1 Inhibitor 2
Catalog No. A15368 PIM-1 InhibitorPIM-1 inhibitor 2 is a potent Pim-1 kinase inhibitor (Ki = 91 nM). Learn More -
CX-6258 hydrochloride hydrate
Catalog No. A15055 Pim InhibitorCX-6258 hydrochloride hydrate is a potent, orally efficacious Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor with excellent biochemical potency and kinase selectivity. Learn More -
LGB-321 HCl
Catalog No. A14420 Pan-PIM kinase inhibitorLGB-321 HCl is a potent and selective ATP-competitive small molecule inhibitor of PIM kinases (Pan-PIM kinase inhibitor). Learn More -
CX-6258 HCl
Catalog No. A14275 Pan-PIM kinase inhibitorCX-6258 HCl is a potent, orally efficacious pan-Pim kinase inhibitor with IC50 of 5 nM, 25 nM and 16 nM for Pim1, Pim2, and Pim3. Learn More -
CX-6258
Catalog No. A12896 Pim InhibitorCX-6258 is a potent, selective, and orally efficacious pan-Pim kinases inhibitor. Learn More -
TCS PIM-1 4a (SMI-4a)
Catalog No. A11967 Pim inhibitorTCS PIM-1 4a is a selective and ATP-competitive Pim kinase inhibitor (IC50 values = 24 and 100 nM for Pim-1 and Pim-2, respectively). Learn More -
AZD1208
Catalog No. A13203 pan-Pim kinase inhibitorAZD1208 is orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity. Learn More -
(Z)-SMI-4a
Catalog No. A11945 Pim InhibitorSIM-4a is a Pim kinase inhibitor that blocks mTORC1 activity via activation of AMPK. Mostly potent to Pim-2, does not significantly inhibit any other serine/threonine- or tyrosine-kinases. Learn More -
PIM447 (LGH447)
Catalog No. A16807 Pim inhibitorPIM447 is a novel pan-PIM kinase inhibitor with Ki values of 6 pM, 18 pM, 9 pM for PIM1, PIM2, PIM3 respectively. It also inhibits GSK3β, PKN1, and PKCτ, but at a significantly lower potency with IC50 between 1 and 5 μM (>105-fold differential relative to the Ki on PIMs). Learn More -
AZD1208 HCl
Catalog No. A16927 PIM kinases inhibitorAZD1208 hydrochloride is a novel, orally bioavailable, highly selective PIM kinases inhibitor. Learn More -
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New
SMI-16a
Catalog No. A17157 Pim kinase inhibitorSMI-16a is a selective Pim kinase inhibitor with IC50 values of 0.15, 0.02 and 48 μM for Pim1, Pim2 and PC3 cells, respectively. Learn More -
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GDC-0339
Catalog No. A20920 Pim kinase inhibitorGDC-0339 is a potent, orally bioavailable and well tolerated pan-Pim kinase inhibitor, with Kis of 0.03 nM, 0.1 nM and 0.02 nM for Pim1, Pim2 and Pim3, respectively. GDC-0339 is discovered as a potential treatment of multiple myeloma. Learn More -
INCB053914 phosphate
Catalog No. A21444 Pim inhibitorINCB053914 phosphate is an inhibitor of Pim extracted from patent WO 2017044730 A1, compound 1; has an IC50 of less than 35 nM. Learn More
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