Syk

Catalog No.Inhibitor Name SykOther
A10769R406 besylate
**
Flt3
A10770R406 (Tamatinib)
**
Flt3
A10771R788 Disodium
**
A12731PRT062607 HCl
****
FGR,MLK1,YES
A11926Fostamatinib
**
Adenosine A3 receptor,Adenosine transporter,Monoamine transporter
A16240MNS
*
p97,Src
A15524PRT-060318
****
A13884Entospletinib
***
A11320BAY-61-3606
***
A12162Piceatannol
Lyn,PKA,PKC
A11952P505-15 (PRT062607, BIIB057)
****
FGR, MLK1
A14161R112
*

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. R112

    Catalog No. A14161
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    Syk inhibitor
    R112 is a Syk inhibitor. R112 inhibited degranulation induced by anti-IgE cross-linking in mast cells and also blocked leukotriene C4 production and all proinflammatory cytokines tested. Learn More
  2. PRT-060318

    Catalog No. A15524
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    Syk inhibitor
    PRT-060318 is a novel selective inhibitor of the tyrosine kinase Syk, as an approach to HIT treatment. Learn More
  3. BAY 61-3606 dihydrochloride

    Catalog No. A15017
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    Syk Inhibitor
    BAY 61-3606 is a potent (Ki = 7.5 nM) and selective inhibitor of Syk kinase. Learn More
  4. R406 besylate

    Catalog No. A10769
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    Syk Inhibitor
    R406 is an orally available spleen tyrosine kinase inhibitor with an IC50 of 41 nM. Learn More
  5. PRT062607 HCL

    Catalog No. A12731
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    Syk Inhibitor
    PRT2607, also known as PRT062607, P505-15, and BIIB057, is a novel, highly selective, and orally bioavailable small molecule SYK inhibitor (SYK IC(50) = 1 nM) with anti-SYK activity that is at least 80-fold greater than its affinity for other kinases. Learn More
  6. GS-9973 (Entospletinib)

    Catalog No. A13884
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    Syk inhibitor
    GS-9973 is an oral inhibitor of spleen tyrosine kinase (Syk), with potential antineoplastic activity. Learn More
  7. Piceatannol

    Catalog No. A12162
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    Syk Inhibitor
    Piceatannol is an anti-inflammatory, immunomodulatory and antiproliferative agent. Inhibits p56lck and syk protein tyrosine kinases and inhibits TNF-induced NF-??B activation and gene expression. Learn More
  8. P505-15 (PRT062607, BIIB057)

    Catalog No. A11952
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    Syk inhibitor
    P505-15 (also known as PRT062607) is a novel, highly selective, and orally bioavailable small molecule SYK inhibitor (SYK IC(50) = 1 nM) with anti-SYK activity that is at least 80-fold greater than its affinity for other kinases. Learn More
  9. R788 (Fostamatinib)

    Catalog No. A11926
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    Syk inhibitor
    R788 (Fostamatinib) is an important spleen tyrosine kinase (Syk) inhibitor, showing efficacy against kinase-mediated IgG Fc gamma receptor signaling. Learn More
  10. BAY 61-3606

    Catalog No. A11320
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    Syk Inhibitor
    BAY 61-3606 is a cell-permeable imidazopyrimidine compound that acts as a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src. Learn More
  11. R935788 (Fostamatinib disodium, R788)

    Catalog No. A10771
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    Syk Inhibitor
    R935788 (Fostamatinib disodium) is a potent orally available inhibitor of Syk that inhibits tumor growth in the Eμ- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling. Learn More
  12. R406 (Tamatinib)

    Catalog No. A10770
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    Syk Inhibitor
    R406 is an orally available spleen tyrosine kinase inhibitor with an IC50 of 41 nM. Learn More
  13. MNS

    Catalog No. A16240
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    Src/Syk inhibitor
    MNS is a potent and selective inhibitor of Src and Syk tyrosine kinases. Learn More

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