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| Catalog No. | Inhibitor Name | Syk | Other |
|---|---|---|---|
| A10769 | R406 besylate | ** | Flt3 |
| A10770 | R406 (Tamatinib) | ** | Flt3 |
| A10771 | R788 Disodium | ** | |
| A12731 | PRT062607 HCl | **** | FGR,MLK1,YES |
| A11926 | Fostamatinib | ** | Adenosine A3 receptor,Adenosine transporter,Monoamine transporter |
| A16240 | MNS | * | p97,Src |
| A15524 | PRT-060318 | **** | |
| A13884 | Entospletinib | *** | |
| A11320 | BAY-61-3606 | *** | |
| A12162 | Piceatannol | Lyn,PKA,PKC | |
| A11952 | P505-15 (PRT062607, BIIB057) | **** | FGR, MLK1 |
| A14161 | R112 | * |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
21 Item(s)
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BAY 61-3606
Catalog No. A11320 Syk InhibitorBAY 61-3606 is a cell-permeable imidazopyrimidine compound that acts as a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src. Learn More -
R788 (Fostamatinib)
Catalog No. A11926 Syk inhibitorR788 (Fostamatinib) is an important spleen tyrosine kinase (Syk) inhibitor, showing efficacy against kinase-mediated IgG Fc gamma receptor signaling. Learn More -
P505-15 (PRT062607, BIIB057)
Catalog No. A11952 Syk inhibitorP505-15 (also known as PRT062607) is a novel, highly selective, and orally bioavailable small molecule SYK inhibitor (SYK IC(50) = 1 nM) with anti-SYK activity that is at least 80-fold greater than its affinity for other kinases. Learn More -
TAK-659 hydrochloride
Catalog No. A21885 Syk inhibitorTAK-659 hydrochloride is a potent, selective and orally available spleen tyrosine kinase (Syk) inhibitor with an IC50 of 3.2 nM. Learn More -
Fostamatinib disodium hexahydrate
Catalog No. A21873 Syk inhibitorFostamatinib disodium hexahydrate (R788 disodium hexahydrate), a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM. Learn More -
PRT 062070 (Cerdulatinib)
Catalog No. A14147 Dual Syk and JAK inhibitorPRT062070 is a novel, oral, dual spleen tyrosine kinase (Syk) and janus kinase (JAK) inhibitor. Cerdulatinib preferentially inhibited JAK1 and JAK3 dependent cytokine mediated signaling and functional responses in various cell types. Learn More -
BAY 61-3606 dihydrochloride
Catalog No. A15017 Syk InhibitorBAY 61-3606 is a potent (Ki = 7.5 nM) and selective inhibitor of Syk kinase. Learn More -
PRT-060318
Catalog No. A15524 Syk inhibitorPRT-060318 is a novel selective inhibitor of the tyrosine kinase Syk, as an approach to HIT treatment. Learn More -
R112
Catalog No. A14161 Syk inhibitorR112 is a Syk inhibitor. R112 inhibited degranulation induced by anti-IgE cross-linking in mast cells and also blocked leukotriene C4 production and all proinflammatory cytokines tested. Learn More -
Lanraplenib
Catalog No. A12959 SYK inhibitorLanraplenib (GS-9876) is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases. Learn More -
RO9021
Catalog No. A16686 ATP-competitive SYK inhibitorRO9021 is an orally bioavailable, novel ATP-competitive inhibitor of SYK, with an average IC50 of 5.6 nM. Learn More -
SRX3207
Catalog No. A22305 Syk/PI3K inhibitorSRX3207 is an orally active and first-in-class dual Syk/PI3K inhibitor, with IC50 values of 10.7 nM and 861 nM for Syk and PI3Kα, respectively. SRX3207 relieves tumor immunosuppression. Learn More -
R406 besylate
Catalog No. A10769 Syk InhibitorR406 is an orally available spleen tyrosine kinase inhibitor with an IC50 of 41 nM. Learn More -
TAK-659
Catalog No. A20450 SYK/FLT3 inhibitorTAK-659 is a highly potent, selective, reversible and orally available dual inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), with an IC50 of 3.2 nM and 4.6 nM for SYK and FLT3, respectively. Learn More -
Gusacitinib
Catalog No. A19883 SYK/JAK inhibitorGusacitinib (ASN-002) is a potent dual inhibitor of spleen tyrosine kinase (SYK) and janus kinase (JAK) with IC50 values of 5-46 nM. Learn More -
MNS
Catalog No. A16240 Src/Syk inhibitorMNS is a potent and selective inhibitor of Src and Syk tyrosine kinases. Learn More -
PRT062607 HCL
Catalog No. A12731 Syk InhibitorPRT2607, also known as PRT062607, P505-15, and BIIB057, is a novel, highly selective, and orally bioavailable small molecule SYK inhibitor (SYK IC(50) = 1 nM) with anti-SYK activity that is at least 80-fold greater than its affinity for other kinases. Learn More -
GS-9973 (Entospletinib)
Catalog No. A13884 Syk inhibitorGS-9973 is an oral inhibitor of spleen tyrosine kinase (Syk), with potential antineoplastic activity. Learn More -
Piceatannol
Catalog No. A12162 Syk InhibitorPiceatannol is an anti-inflammatory, immunomodulatory and antiproliferative agent. Inhibits p56lck and syk protein tyrosine kinases and inhibits TNF-induced NF-??B activation and gene expression. Learn More -
R935788 (Fostamatinib disodium, R788)
Catalog No. A10771 Syk InhibitorR935788 (Fostamatinib disodium) is a potent orally available inhibitor of Syk that inhibits tumor growth in the Eμ- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling. Learn More -
R406 (Tamatinib)
Catalog No. A10770 Syk InhibitorR406 is an orally available spleen tyrosine kinase inhibitor with an IC50 of 41 nM. Learn More
21 Item(s)
per page
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