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Cytoskeleton



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Catalog No. Product Name Application Product Information
A15915

Dyngo-4a

Dynamin inhibitor
Dyngo-4a is a potent dynamin inhibitor with IC50 of 0.38 uM, 1.1uM, and 2.3 uM for DynI (brain), DynI (rec), and DynII (rec), respectively.
A12726 SALE

Dynasore

Dynamin inhibitor
Dynasore is a non-competitive inhibitor of dynamin 1, dynamin 2 and mitochondrial dynamin (Drp1) GTPase activity
A14316 SALE

Mdivi-1

DRP1 inhibitor
Mdivi-1 is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with IC50 of 1-10 uM.
A13968

Leukadherin 1

Integrin agonist
Leukadherin 1 is an allosteric activator of CD11b/CD18. Increases CD11b/CD18-dependent cell adhesion to fibrinogen (EC50 = 4 μM).
A11614

Zaurategrast (CDP323)

VCAM-1 antagonist
CDP323 is a small-molecule prodrug antagonist of the vascular cell adhesion molecule 1 binding to ??4-integrins
A15456 SALE

E7820

lpha-2-integrin inhibitor
E7820 is a small molecule and aromatic sulfonamide derivative with potential antiangiogenic and antitumor activities. E7820 inhibits angiogenesis by suppressing integrin alpha 2, a cell adhesion molecule expressed on endothelial cells.
A12876

Pyrintegrin

-
Pyrintegrin is a cell-permeable small molecule that promotes human embryonic stem cell (hESC) survival by > 30-fold.
A12372 SALE

Cilengitide

-
Cilengitide is a cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(v)beta(3) and alpha(v)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis.
A15538

RGD (Arg-Gly-Asp) Peptides

Inhibits integrin binding to RGD motifs
RGD (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.
A14923

Cyclo (-RGDfK)

αvβ3 integrin inhibitor
Cyclo (-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin.
A12787 SALE

Firategrast (SB 683699)

α4β1/α4β7 integrin antagonist
Firategrast is an orally bioavailable alpha4 beta1/alpha4 beta7 integrin antagonist designed to reduce trafficking of lymphocytes into the central nervous system (CNS).
A15918

Cyclo(RGDyK)

Integrin inhibitor
Cyclo(RGDyK) is a potent and selective alphaVbeta3 integrin inhibitor with IC50 of 20 nM.
A12371

Cilengitide trifluoroacetate

Integrin inhibitor
Cilengitide is a cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(v)beta(3) and alpha(v)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis.
A15967

CWHM12

αV integrins inhibitor
CWHM 12 can suppress all 5 alpha V integrins. CWHM12 not only worked the same way to prevent fibrosis as the genetic deletion method, it also prevent the progression of existing fibrosis in the liver and lungs and reversed some of the damage caused by fibrosis to those organs.
A15841 SALE

Dimethylenastron

Kinesin Eg5 inhibitor
Dimethylenastron is an inhibitor of mitotic motor kinesin Eg5 with IC50 value of 200 nM.
A10486 SALE

Ispinesib (SB-715992)

KSP Inhibitor
Ispinesib (SB-715992) is a potent inhibitor of kinesin spindle protein, a kinesin motor protein essential for the formation of a bipolar mitotic spindle and cell cycle progression through mitosis.
A11170 SALE

AZ 3146

Mps1 inhibitor

AZ 3146 is a potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM). It interferes with chromosome alignment and overrides spindle assembly checkpoint and also Inhibits the recruitment of Mad1, Mad2 and centromere protein E (CENP-E) to kinetochores.

A15956

EMD534085

Kinesin inhibitor
EMD534085 is a kinesin inhibitor currently in clinical development.
A15844 SALE

K 858

Kinesin Eg5 inhibitor
K 858 is a selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor with IC50 value of 1.3 uM.
A15001

ARRY-520 R enantiomer

KSP inhibitor
ARRY-520 R enantiomer is the R form of ARRY-520, which is a synthetic, small molecule kinesin spindle protein (KSP) inhibitor with IC50 of 6 nM.
A14234

ARQ 621

Eg5 mitotic motor protein inhibitor
ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor.
A14290

MPI-0479605

Mps1 inhibitor
MPI-0479605 is an ATP competitive and selective inhibitor of mitotic kinase Mps1
A10828 SALE

SB 743921

KSP Inhibitor
SB 743921, a second generation KSP inhibitor, is a highly potent and active therapeutic in preclinical models of cancer.
A11976

Monastrol

Kinesin-5(KIF11) inhibitor
Monastrol is a potent, cell permeable non-tubulin-interacting mitosis inhibitor. Monastrol blocks mitosis (IC5N/A = 14 ?M) by binding to the mitotic kinesin Eg5, a motor protein required for spindle bipolarity.
A11435 SALE

GSK-923295

CENP-E inhibitor
GSK-923295, is a small-molecule inhibitor of the mitotic kinesin centromere-associated protein E, (CENP-E).
A11050

Arry-520 (Filanesib)

KSP inhibitor
KSP inhibitor ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5) with potential antineoplastic activity.
A11218

Mps1-IN-1

Mps1 inhibitor
Mps1-IN-1 is a highly potent and selectibe Mpsl inhibitor with IC50 of 367 nM; >1000-fold selectivity relative to the 352 member kinase panel with the major exceptions of Alk and Ltk.
A11593

Tonabersat (SB-220453)

gap-junction modulator
Tonabersat is a novel benzopyran derivative that blocks the cortical spreading depression proposed to be associated with migraine attacks.
A14865

Gap 26

Gap junction blocker
Gap 26 is a connexin mimetic peptide, corresponding to residues 63-75 of connexin 43, which is a gap junction blocker.
A14866 SALE

Gap 27

Gap junction blocker
Gap 27 is a peptide derived from connexin 43 that is a selective gap junction blocker.
A14876

GnRH Associated Peptide (GAP) (1-13), human

-
N/A
A14920

10Panx

Panx-1 mimetic inhibitor
10Panx, Panx-1 mimetic inhibitory peptide, is a blocker of pannexin-1 gap junctions.
A14921

Scrambled 10Panx

Panx-1 mimetic inhibitor
Scrambled 10Panx, Panx-1 mimetic inhibitory peptide, is a blocker of pannexin-1 gap junctions.
A15091

GAP-134 (Danegaptide)

Gap Junction Modifier
GAP-134 , a small modified dipeptide, has been identified as a potent and selective second generation gap junction modifier with oral bioavailability.
A15092

GAP-134 Hydrochloride

Gap-junction modifier
GAP-134 Hydrochloride, a small modified dipeptide, has been identified as a potent and selective second generation gap junction modifier with oral bioavailability.

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