Estrogen Receptors

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Catalog No. Product Name Application Product Information
A11018 SALE

TAK-875 (Fasiglifam)

GPR agonist
TAK-875 is a potent, selective, and orally bioavailable GPR40 agonist.
A13740 SALE


Zearalenone is a phytoestrogenic mycotoxin usually produced by Fusarium species, is shown to be a cytotoxic compound, but alos binds to the estrogen receptor (ER) (IC50 values are 166 and 240 nM for ERβ and ERα respectively) and was found to stimulate the transcriptional activity of both subtypes at concentrations between 1 - 10 nM.

Arzoxifene HCl

Arzoxifene HCl is the hydrochloride salt of arzoxifene, a synthetic aromatic derivative with anti-estrogenic properties. Arzoxifene binds to estrogen receptors as a mixed estrogen agonist/antagonist.
A13299 SALE

XCT 790

ERRα antagonist/inverse agonist
XCT 790 is a potent and specific inverse agonist of ERRα.


estrogen receptor modulator
Ospemifene is a non-hormonal selective estrogen receptor modulator (SERM).


ETBR antagonist
IRL-2500 is a potent, selective ETBR antagonist. It shows some selectivity for ETB receptors (IC50 values are 1.3 and 94 nM for ETB and ETA receptors respectively).


Estrogen modulator
Bazedoxifene is a third generation selective modulator of estrogen receptor.


ERRβ and ERRγ agonist
DY131(GSK 9089) is a novel selective agonist of ERRα and ERRβ.


Estrogen receptor modulator
Toremifene is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis.
A12639 SALE


Estrogen receptor antagonist
Endoxifen is a secondary metabolite of tamoxifen. It is a primary metabolite responsible for the effectiveness of tamoxifen in ER-positive breast cancer.


estrogen receptor downregulator and antagonist
AZD9496 is a potent and orally bioavailable selective estrogen receptor downregulator and antagonist.


Estrogen receptor antagonist
4-Hydroxytamoxifen is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer.

RAD1901 HCl salt

RAD1901 is an orally available, selective estrogen receptor degrader (SERD) and selective estrogen receptor modulator (SERM), with potential antineoplastic and estrogen-like activities.


Estrogen receptor degrader
GDC-0810 an orally bioavailable Selective Estrogen Receptor Degrader (SERD) that demonstrates robust activity in tamoxifen-resistant breast cancer xenografts.

Acolbifene (EM 652, SCH57068)

estrogen receptor modulator
acolbifene is a substance being studied in the prevention of breast cancer in women at high risk of breast cancer. Acolbifene hydrochloride binds to estrogen receptors in the body and blocks the effects of estrogen in the breast. It is a type of selective estrogen receptor modulator (SERM).


Liquiritigenin is a plant-derived highly selective estrogen receptor ?? agonist
A10410 SALE

Fulvestrant (Faslodex)

Aromatase inhibitor
Fulvestrant is an estrogen receptor antagonist with no agonist effects, which works both by down-regulating and by degrading the estrogen receptor.
A10308 SALE


Dienogest is an oral progestin that has antiandrogenic activity and as a result can improve androgenic symptoms.
A10495 SALE


ERRα and ERRγ inverse agonist
Kaempferol is found to inhibit bovine aorta myosin light chain kinase with a Ki of 0.3-0.5 microM and also is found to inhibit VEGF expression and in vitro angiogenesis through a novel ERK-NFκB-cMyc-p21 pathway.
A10451 SALE


Estrogen/progestogen Receptor agonist
Hexestrol is a carcinogenic synthetic estrogen that inhibits microtubule polymerization and the formation of ribbon structures. It is an inhibitor of lipid peroxidation.
A10375 SALE

Evista (Raloxifene HCl)

Raloxifene is an oral selective estrogen receptor modulator (SERM) that has estrogenic actions on bone and anti-estrogenic actions on the uterus and breast. It is used in the prevention of osteoporosis in postmenopausal women.
A10439 SALE


GPR119 agonist
GSK-1292263 is a novel GPR119 agonist.


ER?? agonist
LY500307 is a potent, selective estrogen receptor beta agonist with an EC50 of 0.66 nM.

Bazedoxifene acetate

Bazedoxifene is a third generation selective estrogen receptor modulator (SERM). Bazedoxifene acetate significantly prevents bone mass loss at 20 mg/day in healthy postmenopausal women with normal or low bone mineral density.
A11667 SALE


Ethisterone is a progestogen hormone.
A10230 SALE

Clomifene citrate

Clomifene inhibits estrogen receptors in hypothalamus, inhibiting negative feedback of estrogen on gonadotropin release, leading to up-regulation of the hypothalamic-Cpituitary-Cadrenal axis.


Drospirenone is a synthetic hormone used in birth control pills.


GPR40 Inhibitor
GW 9508 is a cell-permeable aminophenylpropanoate that acts as a potent and selective agonist for the G-protein coupled receptor (GPCR) GRP40/FFA1 receptor (EC50 ?50 nM) with reduced activity towards family members GRP120 (EC50 ?3.5 μM), GRP41/GRP43 (EC50 >50 μM), as well as a panel of eight other free fatty acid (FFA) and prostaglandin receptors.

Mifepristone (Mifeprex)

Mifepristone, an antioxidant and glucocorticoid receptor antagonist, demonstrates the ability to suppress activation of NFκB, a nuclear transcription factor that affects the expression of various adhesion molecules and several inflammatory genes.

Endoxifen E-isomer hydrochloride

Endoxifen (E-isomer hydrochloride) is a tamoxifen metabolite and potent Selective Estrogen Response Modifier (SERM).

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