Estrogen Receptors

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  1. Agonist (4)
  2. Antagonist (1)
  3. Inhibitor (2)


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Catalog No. Product Name Application Product Information
A11665

Bazedoxifene acetate

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Bazedoxifene is a third generation selective estrogen receptor modulator (SERM). Bazedoxifene acetate significantly prevents bone mass loss at 20 mg/day in healthy postmenopausal women with normal or low bone mineral density.
A10230

Clomifene citrate

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Clomifene inhibits estrogen receptors in hypothalamus, inhibiting negative feedback of estrogen on gonadotropin release, leading to up-regulation of the hypothalamic-Cpituitary-Cadrenal axis.
A10308

Dienogest

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Dienogest is an oral progestin that has antiandrogenic activity and as a result can improve androgenic symptoms.
A10336

Drospirenone

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Drospirenone is a synthetic hormone used in birth control pills.
A11667

Ethisterone

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Ethisterone is a progestogen hormone.
A10375

Evista (Raloxifene HCl)

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Raloxifene is an oral selective estrogen receptor modulator (SERM) that has estrogenic actions on bone and anti-estrogenic actions on the uterus and breast. It is used in the prevention of osteoporosis in postmenopausal women.
A10410

Fulvestrant (Faslodex)

Aromatase inhibitor
Fulvestrant is an estrogen receptor antagonist with no agonist effects, which works both by down-regulating and by degrading the estrogen receptor.
A10439

GSK1292263

GPR119 agonist
GSK-1292263 is a novel GPR119 agonist.
A11965

GW9508

GPR40 Inhibitor
GW 9508 is a cell-permeable aminophenylpropanoate that acts as a potent and selective agonist for the G-protein coupled receptor (GPCR) GRP40/FFA1 receptor (EC50 ?50 nM) with reduced activity towards family members GRP120 (EC50 ?3.5 μM), GRP41/GRP43 (EC50 >50 μM), as well as a panel of eight other free fatty acid (FFA) and prostaglandin receptors.
A10451

Hexestrol

Estrogen/progestogen Receptor agonist
Hexestrol is a carcinogenic synthetic estrogen that inhibits microtubule polymerization and the formation of ribbon structures. It is an inhibitor of lipid peroxidation.
A10550

LY500307

ER?? agonist
LY500307 is a potent, selective estrogen receptor beta agonist with an EC50 of 0.66 nM.
A10591

Mifepristone (Mifeprex)

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Mifepristone, an antioxidant and glucocorticoid receptor antagonist, demonstrates the ability to suppress activation of NFκB, a nuclear transcription factor that affects the expression of various adhesion molecules and several inflammatory genes.
A11018

TAK-875 (Fasiglifam)

GPR agonist
TAK-875 is a potent, selective, and orally bioavailable GPR40 agonist.
A13299

XCT 790

ERRα antagonist/inverse agonist
XCT 790 is a potent and specific inverse agonist of ERRα.
A13740

Zearalenone

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Zearalenone is a phytoestrogenic mycotoxin usually produced by Fusarium species, is shown to be a cytotoxic compound, but alos binds to the estrogen receptor (ER) (IC50 values are 166 and 240 nM for ERβ and ERα respectively) and was found to stimulate the transcriptional activity of both subtypes at concentrations between 1 - 10 nM.

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