GSK-3

Inhibitory Selectivity
Catalog No.Inhibitor Name GSK-3 GSK-3α GSK-3β Other Targets
A10825SB216763
**
**
A11085CHIR-98014
****
****
Cdc2
A11223TWS119
**
A11592Tideglusib
*
A11061SB415286
*
*
A10199CHIR-99021
***
****
A13060AZD2858
*
A12819AZD1080
***
**
A13728AR-A014418
**
A11941TDZD-8
*
A12741LY2090314
****
****
A15555BIO-acetoxime
***
***
A14196IM-12
**
A10471Indirubin
*
CDK2/CyclinA,CDK5/p35,CDK1/CyclinB
A15526Bikinin
A143031-Azakenpaullone
A16280Indirubin-3-monoxime
***
CDK1/5
A16230CP21R7

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



19 Item(s)

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Catalog No. Product Name Application Product Information
A14303

1-Azakenpaullone

-
1-Azakenpaullone is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25.
A13728 SALE

AR-A 014418

GSK-3 inhibitor
AR-A 014418 is a selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50 = 104 nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC50 values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.
A12819 SALE

AZD1080

GSK3 inhibitor
AZD1080 is a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans.
A13060 SALE

AZD2858

GSK-3β inhibitor
AZD2858 is a selective GSK-3 inhibitor with an IC50 of 68 nM, activating Wnt signaling, increases bone mass in rats.
A15526 SALE

Bikinin

-
Bikinin is a potent inhibitor of plant GSK-3/Shaggy-like kinase; activates BR signaling downstream of the BR receptor.
A15555 SALE

BIO-acetoxime

GSK-3 inhibitor
N/A
A11085 SALE

CHIR-98014

GSK-3 inhibitor
CHIR-98014 is a very potent, selective, cell-permeable reversible inhibitor of GSK-3.
A10199 SALE

CHIR-99021

GSK-3 Inhibitor
CHIR99021 is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively.
A16230 SALE

CP21R7

GSK-3β inhibitor
CP21R7 is a potent and selective GSK-3β inhibitor.
A15471

GSK-3b

GSK-3 beta Inhibitor
N/A
A14196 SALE

IM-12

GSK-3β inhibitor
IM-12 is a cell-permeable indolylmaleimide that acts as a Glycogen synthase kinase 3β (GSK-3β) inhibitor, activating downstream components of canonical Wnt signaling.
A10471 SALE

Indirubin

CDK & GSK-3β inhibitor
Indirubin, the active constituent of a Chinese antileukaemia medicine, is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 μM and 0.6 μM.
A16280

Indirubin-3-monoxime

GSK-3β inhibitor
Indirubin-3'-monoxime is a powerful inhibitor of GSK-3β with IC50 of 22nM, also inhibits CDK1/5 (IC50 = 180/100 nM).
A12741 SALE

LY2090314

GSK-3 inhibitor
LY2090314 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) which plays an important role in many pathways, including initiation of protein synthesis, cell proliferation, cell differentiation, and apoptosis.
A10825 SALE

SB 216763

GSK-3 inhibitor
SB 216763 is a potent and selective cell permeable ATP-competitive inhibitor of GSK3α with an IC50 value of 34 nM (similar potency for GSK3β).
A11061 SALE

SB 415286

GSK-3 inhibitor
SB 415286 is a potent and selective cell-permeable, ATP-competitive inhibitor of GSK3α with an IC50 value of 78 nM (similar potency for GSK3β) and a Ki value of 31 nM.
A11941 SALE

TDZD-8

GSK-3 Inhibitor
TDZD-8 protects the brain against I/R injury by inhibiting GSK-3beta activity
A11592 SALE

Tideglusib

GSK-3 Inhibitor
Tideglusib is a GSK-3 inhibitor currently in phase II clinical trials for the treatment of Alzheimer disease and progressive supranuclear palsy
A11223 SALE

TWS119

GSK-3 Inhibitor
TWS119 is a 4,6 disubstituted pyrrolopyrimidine that potently inhibits GSK3β with an IC50 value of 30 nM.1 At 400 nM.

19 Item(s)

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