GSK-3

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  1. Antagonist (1)
  2. Inhibitor (17)


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Catalog No. Product Name Application Product Information
A13728

AR-A 014418

GSK-3 inhibitor
AR-A 014418 is a selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50 = 104 nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC50 values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.
A12819

AZD1080

GSK3 inhibitor
AZD1080 is a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans.
A13060

AZD2858

GSK-3β inhibitor
AZD2858 is a selective GSK-3 inhibitor with an IC50 of 68 nM, activating Wnt signaling, increases bone mass in rats.
A15555

BIO-acetoxime

GSK-3 inhibitor
N/A
A11085

CHIR-98014

GSK-3 inhibitor
CHIR-98014 is a very potent, selective, cell-permeable reversible inhibitor of GSK-3.
A10199

CHIR-99021

GSK-3 Inhibitor
CHIR99021 is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively.
A16230

CP21R7

GSK-3β inhibitor
CP21R7 is a potent and selective GSK-3β inhibitor.
A15471

GSK-3b

GSK-3 beta Inhibitor
N/A
A14196

IM-12

GSK-3β inhibitor
IM-12 is a cell-permeable indolylmaleimide that acts as a Glycogen synthase kinase 3β (GSK-3β) inhibitor, activating downstream components of canonical Wnt signaling.
A10471

Indirubin

CDK inhibitor
Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases.
A16280

Indirubin-3-monoxime

GSK-3β inhibitor
Indirubin-3'-monoxime is a powerful inhibitor of GSK-3β with IC50 of 22nM, also inhibits CDK1/5 (IC50 = 180/100 nM).
A12741

LY2090314

GSK-3 inhibitor
LY2090314 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) which plays an important role in many pathways, including initiation of protein synthesis, cell proliferation, cell differentiation, and apoptosis.
A10825

SB 216763

GSK-3 inhibitor
SB 216763 is a potent and selective cell permeable ATP-competitive inhibitor of GSK3α with an IC50 value of 34 nM (similar potency for GSK3β).
A11061

SB 415286

GSK-3 inhibitor
SB 415286 is a potent and selective cell-permeable, ATP-competitive inhibitor of GSK3α with an IC50 value of 78 nM (similar potency for GSK3β) and a Ki value of 31 nM.
A11143

SB-705498

TRPV1 antagonist
SB-705498 is a potent, selective and orally bioavailable TRPV1 antagonist.
A11941

TDZD-8

GSK-3 Inhibitor
TDZD-8 protects the brain against I/R injury by inhibiting GSK-3beta activity
A11592

Tideglusib

GSK-3 Inhibitor
Tideglusib is a GSK-3 inhibitor currently in phase II clinical trials for the treatment of Alzheimer disease and progressive supranuclear palsy
A11223

TWS119

GSK-3 Inhibitor
TWS119 is a 4,6 disubstituted pyrrolopyrimidine that potently inhibits GSK3β with an IC50 value of 30 nM.1 At 400 nM.

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