PPAR

Actions
  1. Agonist (11)
  2. Antagonist (6)


23 Item(s)

per page

Set Descending Direction
Catalog No. Product Name Application Product Information
A12492

Aleglitazar

PPAR-α/γ agonist
Aleglitazar is a new dual PPAR-α/γ agonist with IC50 of 2.8 nM/4.6 nM.
A15013

Balaglitazone

PPAR-γ partial agonist
Balaglitazone is a novel partial agonist of PPAR-gamma (γ).
A15836

BMS-687453

PPAR agonist
BMS-687453 is a potent and selective peroxisome proliferator activated receptor (PPAR) alpha agonist, with an EC(50) of 10 nM for human PPARalpha and approximately 410-fold selectivity vs human PPARgamma in PPAR-GAL4 transactivation assays.
A16308

CDDO-Im

PPARγ Agonist
CDDO-Im is a novel synthetic triterpenoid more potent than its parent compound CDDO both in vitro and in vivo; PPARγ Agonist.
A11137

Cetaben

Peroxisome Proliferator
Cetaben is a unique, PPARα-independent peroxisome proliferator with hypolipidemic activity that inhibits cholesterol synthesis in the human hepatoma Hep-G2 cells resulting in reversible changes in Golgi morphology.
A11727

Ciprofibrate

-
Ciprofibrate is a fibrate.
A16309

DG172 dihydrochloride

PPARβ/δ inverse agonist
DG-172 is an orally active potent PPARβ/δ inverse agonist (IC50 = 26.9 nM). DG-172 inhibits Angptl4 gene expression in mouse myoblasts (IC50 = 9.5 nM) in vitro.
A15454

Elafibranor

PPAR agonist
Elafibranor is an agonist of the peroxisome proliferator-activated Receptor-α and -δ, induces resolution of nonalcoholic steatohepatitis without fibrosis worsening.
A10424

Gemfibrozil (Lopid)

-
Gemfibrozil (Lopid) is a compound used to lower lipid levels.
A12392

GSK 0660

PPARδ antagonist
GSK 0660 is a selective PPARβ antagonist (IC50 values are 0.155, > 10 and ≥ 10 µM at PPARβ, PPARα and PPARγ respectively).
A12391

GSK-3787

PPAR antagonist
GSK-3787 is a potent and selective peroxisome proliferator-activated receptor δ (PPARδ) antagonist (pIC50 = 6.6).
A11437

GW 501516

PPARδ receptor agonist
GW501516 (GW1516 or GSK-516) is a drug that acts as a PPAR?? modulator.
A11982

GW 7647

-
GW 7647 is a potent and highly selective PPARα agonist (EC50 values are 6, 1100 and 6200 nM for human PPARα, PPARγ and PPARδ receptors respectively).
A11984

GW 9662

PPARγ antagonist
GW 9662 is a selective PPARγ antagonist (IC50 values are 3.3, 32 and 2000 nM for PPARγ, PPARα and PPARδ respectively).
A14958

GW0742

PPAR agonist
GW0742 is a selective agonist of PPARδ with EC50 value of 1.1 nM.
A15099

GW1929

PPAR agonist
GW1929 is a synthetic peroxisome proliferator-activated receptor-?? (PPAR??) agonist with IC50 of 6.2 nM and 13 nM for human and mouse, respectively.
A12413

GW6471

PPARα antagonist
GW6471 is a PPARα antagonist, shown to completely inhibit GW409544-induced activation of PPARα.
A11983

L-165,041

-
L-165,041 is a potent PPARδ agonist (Ki = 6 nM); displays > 100-fold selectivity for both mouse and human PPARδ receptors over other subtypes.
A12360

pirinixic acid (WY 14643)

PPARα agonist
WY 14643 is a highly potent PPARα agonist.
A10807

Rosiglitazone (BRL-49653)

PPAR agonist
Rosiglitazone works as an insulin sensitizer, by binding to the PPAR receptors in fat cells and making the cells more responsive to insulin.
A10809

Rosiglitazone maleate

PPAR agonist
Rosiglitazone maleate, an antidiabetic drug, works as an insulin sensitizer, by binding to the PPAR receptors in fat cells and making the cells more responsive to insulin.
A11588

T0070907

PPAR-γ antagonist
T0070907 was identified as a potent and selective PPARgamma antagonist. With an apparent binding affinity (concentration at 50% inhibition of [(3)H]rosiglitazone binding or IC(50)) of 1 nm, T0070907 covalently modifies PPARgamma on cysteine 313 in helix 3 of human PPARgamma2.
A11981

Troglitazone

-
Troglitazone is a selective PPARγ receptor agonist (EC50 values are 780 and 555 nM at murine and human PPARγ receptors respectively).

23 Item(s)

per page

Set Descending Direction