CCR

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  1. Teijin compound 1

    Catalog No. A13380
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    CCR 2 antagonist
    Teijin compound 1 is a specific CCR 2 antagonist with IC50s of 24 and 180 nM in chemotaxis and binding assay, respectively. Learn More
  2. BX471 hydrochloride

    Catalog No. A21886
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    non-peptide CCR1 antagonist
    BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective non-peptide CCR1 antagonist with Ki of 1 nM for human CCR1, and exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4. Learn More
  3. Vercirnon

    Catalog No. A21315
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    CCR9 antagonist
    Vercirnon (GSK-1605786) is an orally bioavailable, selective, and potent antagonist of CCR9, with an IC50 of 10 nM, used in the research of inflammatory bowel diseases. Learn More
  4. RS102895 hydrochloride

    Catalog No. A20918
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    CCR2 antagonist
    RS102895 hydrochloride is a potent CCR2 antagonist, with an IC50 of 360 nM, and shows no effect on CCR1. Learn More
  5. PF-4136309

    Catalog No. A15127
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    CCR2 antagonist
    PF-4136309 is a potent, selective, and orally bioavailable CCR2 antagonist, with IC50s of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2. Learn More
  6. GSK2239633A

    Catalog No. A12175
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    CCR4 antagonist
    GSK2239633A is a CC-chemokine receptor 4 (CCR4) antagonist, which inhibits the binding of [125I]-TARC to human CCR4 with a pIC50 of 7.96±0.11. Learn More
  7. ZK-756326 dihydrochloride

    Catalog No. A16363
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    CCR8 agonist
    ZK-756326 is a potent, selective and non-peptide CCR8 chemokine receptor agonist. ZK 756326 inhibited the binding of the CCR8 ligand I-309 (CCL1), with an IC(50) value of 1.8 μM. Learn More
  8. BMS-813160

    Catalog No. A17040
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    CCR2/CCR5 antagonist
    BMS-813160 is a potent and selective CCR2/CCR5 antagonist with potential immunomodulating and antineoplastic activities. Learn More
  9. Cenicriviroc Mesylate

    Catalog No. A17028
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    CCR2/5 receptors inhibitor
    Cenicriviroc, also known as TAK-652 and TBR-652, is an inhibitor of CCR2 and CCR5 receptors, allowing it to function as an entry inhibitor which prevents the virus from entering into a human cell. CAS: 199673-74-0(LY 334370 hydrochloride); 182563-08-2 (LY 334370 Free Base) Learn More
  10. BI-639667

    Catalog No. A18747
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    Human CCR1 antagonist
    BI-639667 is a potent and selective antagonist of human CCR1. Learn More
  11. PF-04634817

    Catalog No. A18659
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    CCR2 /CCR5 dual antagonist
    PF-04634817 is an orally administered CCR2 and CCR5 chemokine receptor antagonist, for the treatment of diabetic nephropathies and diabetic macular oedema. Learn More
  12. LMD-009

    Catalog No. A18643
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    CCR8 agonist
    LMD-009 is a selective CCR8 nonpeptide agonist. LMD-009 mediates chemotaxis, inositol phosphate accumulation, and calcium release in high potencies with EC50s from 11 to 87 nM. Learn More
  13. INCB3344

    Catalog No. A11465
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    CCR2 antagonist
    INCB3344 is a potent, selective and orally bioavailable CCR2 antagonist with IC50 values of 5.1 nM (hCCR2) and 9.5 nM (mCCR2) in binding antagonism and 3.8 nM (hCCR2) and 7.8 nM (mCCR2) in antagonism of chemotaxis activity. Learn More
  14. GW 766994

    Catalog No. A20039
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    CCR3 antagonist
    GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist, which has entered clinical trial for asthma and eosinophilic bronchitis. Learn More
  15. AZ084

    Catalog No. A19143
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    CCR8 antagonist
    AZ084 is a potent, selective, allosteric and oral active CCR8 antagonist, with a Ki of 0.9 nM. Has potential to treat asthma. Learn More
  16. ML604086

    Catalog No. A18969
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    CCR8 inhibitor
    ML604086 is a selective CCR8 inhibitor, inhibiting CCL1 binding to CCR8 on circulating T-cells. ML604086 inhibits CCL1 mediated chemotaxis and increases in intracellular Ca2+ concentrations. Learn More
  17. NSC5844

    Catalog No. A15924
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    CCR1 agonist
    NSC5844 is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic properties. Learn More
  18. Vicriviroc maleate

    Catalog No. A15276
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    CCR5 antagonist
    Vicriviroc maleate is a CCR5 antagonist with IC50 of 0.91 nM in clinical development for the treatment of HIV-1. Learn More
  19. Maraviroc (UK-427857)

    Catalog No. A10556
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    CCR antagonist
    Maraviroc is an antiretroviral drug in the CCR5 receptor antagonist class used in the treatment of HIV infection. Learn More
  20. Vicriviroc Malate

    Catalog No. A10971
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    CCR5 antagonist
    Vicriviroc Malate is a second generation orally active CCR5 antagonist, which is also a potent inhibitor of HIV-1 entry into target cells, with a mean IC50 =0.46 nM and IC50 =1~10 nM to HIV isolates (n=52). Learn More
  21. INCB8761 (PF-4136309)

    Catalog No. A11136
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    CCR2 Antagonist
    INCB8761(PF-4136309) is a potent, selective, and orally bioavailable CCR2 antagonist. Learn More
  22. INCB 3284 dimesylate

    Catalog No. A11104
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    HCCR2 antagonist
    INCB 3284 dimesylate is a potent, selective hCCR2 antagonist that exhibits potenct antagonism against monocyte chemoattractant molecule binding to hCCR2 and chemotaxis activity. Learn More
  23. MK-0812

    Catalog No. A11127
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    CCR2 antagonist
    MK-0812 is a potent and selective CCR2 antagonist with low nM affinity for CCR2 on human monocytes and low nM in the chemotaxis assay. It has good PK profiles in preclinical species and demonstrated efficacy in animal models. Learn More
  24. BX471

    Catalog No. A14409
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    CCR1 antagonist
    BX471 is a potent, selective non-peptide CCR1 antagonist (Ki = 1 nM for human CCR1), exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4. Learn More
  25. TAK-779

    Catalog No. A13846
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    CCR5 antagonist
    TAK-779 is a novel, potent and selective small-molecule antagonists of CCR5 with the IC50 value of 1.4nM in binding assay. Learn More
  26. Cenicriviroc

    Catalog No. A13643
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    CCR2/CCR5 inhibitor
    Cenicriviroc is an experimental drug candidate for the treatment of HIV infection.Cenicriviroc is an inhibitor of CCR2 and CCR5 receptors, allowing it to function as an entry inhibitor which prevents the virus from entering into a human cell. Learn More
  27. Aplaviroc

    Catalog No. A13471
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    CCR5 entry inhibitor
    Aplaviroc is a CCR5 entry inhibitor developed for the treatment of HIV infection. Learn More
  28. RS 504393

    Catalog No. A15227
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    CCR2 antagonist.
    RS 504393 is a selective CCR2 chemokine receptor antagonist (IC50 values are 98 nM and > 100 uM for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Learn More
  29. CCR4 antagonist 2

    Catalog No. A18471
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    CCR4 antagonist
    CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues. Learn More

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