CCR

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  1. Maraviroc (UK-427857)

    Catalog No. A10556
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    CCR antagonist
    Maraviroc is an antiretroviral drug in the CCR5 receptor antagonist class used in the treatment of HIV infection. Learn More
  2. NSC5844

    Catalog No. A15924
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    CCR1 agonist
    NSC5844 is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic properties. Learn More
  3. Vicriviroc maleate

    Catalog No. A15276
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    CCR5 antagonist
    Vicriviroc maleate is a CCR5 antagonist with IC50 of 0.91 nM in clinical development for the treatment of HIV-1. Learn More
  4. RS 504393

    Catalog No. A15227
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    CCR2 antagonist.
    RS 504393 is a selective CCR2 chemokine receptor antagonist (IC50 values are 98 nM and > 100 uM for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Learn More
  5. Aplaviroc

    Catalog No. A13471
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    CCR5 entry inhibitor
    Aplaviroc is a CCR5 entry inhibitor developed for the treatment of HIV infection. Learn More
  6. Cenicriviroc

    Catalog No. A13643
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    CCR2/CCR5 inhibitor
    Cenicriviroc is an experimental drug candidate for the treatment of HIV infection.Cenicriviroc is an inhibitor of CCR2 and CCR5 receptors, allowing it to function as an entry inhibitor which prevents the virus from entering into a human cell. Learn More
  7. TAK-779

    Catalog No. A13846
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    CCR5 antagonist
    TAK-779 is a novel, potent and selective small-molecule antagonists of CCR5 with the IC50 value of 1.4nM in binding assay. Learn More
  8. BX471

    Catalog No. A14409
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    CCR1 antagonist
    BX471 is a potent, selective non-peptide CCR1 antagonist (Ki = 1 nM for human CCR1), exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4. Learn More
  9. MK-0812

    Catalog No. A11127
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    CCR2 antagonist
    MK-0812 is a potent and selective CCR2 antagonist with low nM affinity for CCR2 on human monocytes and low nM in the chemotaxis assay. It has good PK profiles in preclinical species and demonstrated efficacy in animal models. Learn More
  10. INCB 3284 dimesylate

    Catalog No. A11104
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    HCCR2 antagonist
    INCB 3284 dimesylate is a potent, selective hCCR2 antagonist that exhibits potenct antagonism against monocyte chemoattractant molecule binding to hCCR2 and chemotaxis activity. Learn More
  11. INCB8761 (PF-4136309)

    Catalog No. A11136
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    CCR2 Antagonist
    INCB8761(PF-4136309) is a potent, selective, and orally bioavailable CCR2 antagonist. Learn More
  12. Vicriviroc Malate

    Catalog No. A10971
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    CCR5 antagonist
    Vicriviroc Malate is a second generation orally active CCR5 antagonist, which is also a potent inhibitor of HIV-1 entry into target cells, with a mean IC50 =0.46 nM and IC50 =1~10 nM to HIV isolates (n=52). Learn More
  13. ZK-756326 dihydrochloride

    Catalog No. A16363
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    CCR8 agonist
    ZK-756326 is a potent, selective and non-peptide CCR8 chemokine receptor agonist. ZK 756326 inhibited the binding of the CCR8 ligand I-309 (CCL1), with an IC(50) value of 1.8 μM. Learn More

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