ATM / ATR

Catalog No.Inhibitor Name ATM ATR Other Targets
A10133Dactolisib
***
p110α,p110γ,mTOR (p70S6K)
A10506KU-55933
****
DNA-PK,mTOR,PI3K
A10507KU-60019
****
A11605VE-821
***
A11161Wortmannin
**
*
PI3K,DNA-PK,MLCK
A11586Torin 2
***
**
mTOR,DNA-PK
A11086CP-466722
**
A13289VE-822
*
***
A13328ETP-46464
*
***
mTOR,DNA-PK,PI3Kα
A13191CGK 733
**
**
A13205AZ20
****
mTOR
A15794AZD6738
****
A11991Schisandrin B
*

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. BEZ235 (NVP-BEZ235, Dactolisib)

    Catalog No. A10133
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    PI3K/mTOR Inhibitor
    BEZ235 (NVP-BEZ235) inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. Learn More
  2. Chloroquine Phosphate

    Catalog No. A16445
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    Chloroquine phosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator. Learn More
  3. AZD0156

    Catalog No. A16419
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    ATM inhibitor
    AZD0156 is a potent and selective inhibitors of ATM kinase, with potential chemo-/radio-sensitizing and antineoplastic activities. Learn More
  4. Mirin

    Catalog No. A15842
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    ATM Inhibitor
    Mirin prevents ATM activation in response to double strand breaks (IC50 = 12 uM) and induces G2 cell cycle arrest. Learn More
  5. AZD6738

    Catalog No. A15794
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    ATR inhibitor
    AZD6738 is a potent inhibitor of ATR kinase activity with an IC50 of 1 nM against the isolated enzyme and 74 nM against ATR kinase-dependent CHK1 phosphorylation in cells. Learn More
  6. VE-822

    Catalog No. A13289
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    ATR inhibitor
    VE-822 is an potent ATR inhibitor. Learn More
  7. ETP-46464

    Catalog No. A13328
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    ATR inhibitor
    ETP-46464 is a potent and selective inhibitor of ATR with IC50 of 25 nM. Learn More
  8. AZ-20

    Catalog No. A13205
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    ATR kinase inhibitor
    AZ20 is a potent and selective inhibitor of ATR with an IC50 value of 5 nM. Learn More
  9. CGK 733

    Catalog No. A13191
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    ATM/ATR inhibitor
    CGK733 is a selective inhibitor of ATR and ATM kinases. Induces cell death in prematurely senescent breast cancer cells. Learn More
  10. Torin 2

    Catalog No. A11586
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    mTOR inhibitor
    Torin 2 is a potent and selective mTOR inhibitor (IC50 = 2.1 nM). Displays 800-fold cellular selectivity for mTOR over PI3K (cellular EC50 values are 0.25 and 200 nM for mTOR and PI3K respectively). Learn More
  11. KU-55933

    Catalog No. A10506
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    ATM inhibitor
    KU-55933 is an ATM inhibitor by suppressing cell proliferation and induces apoptosis by blocking Akt in cancer cells with overactivated Akt. Learn More
  12. CP-466722

    Catalog No. A11086
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    ATM inhibitor
    CP-466722 is a specific ATM inhibitor that inhibits cellular ATM-dependent phosphorylation events and disruption of ATM function resulted in characteristic cell cycle checkpoint defects. Learn More
  13. Wortmannin

    Catalog No. A11161
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    PI3K inhibitor

    Wortmannin is a potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC50 = 2 - 4 nM) which also potently inhibits polo-like kinase 1 (PLK1) (IC50 = 5.8 nM).

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  14. KU-60019

    Catalog No. A10507
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    ATM Inhibitor
    KU-60019 is a potent and specific ATM inhibitor with IC50 of 6.3 nM. Learn More
  15. VE-821

    Catalog No. A11605
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    ATM/ATR inhibitor
    VE-821 is a potent and selective inhibitor of protein kinase ATR. Learn More
  16. Schisandrin B

    Catalog No. A11991
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    Schisandrin B is the most abundant dibenzocyclooctadiene isolated from the fruit of Schisandra chinensis (Turcz) Baillon or Wu-Wei-Zi (transliterally meaning "the fruit of five tastes" in Chinese), which is a commonly used tonic herb in Chinese medicine, particularly for the treatment of liver ailments. Learn More
  17. NU6027

    Catalog No. A14136
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    ATR/CDK inhibitor
    NU6027 is a potent inhibitor of cellular ATR activity (IC(50)=6.7 μM) and enhanced hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner. Learn More
  18. AZ32

    Catalog No. A16814
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    ATM inhibitor
    AZ32 is a specific inhibitor of the ATM kinase that possesses good BBB penetration in mouse with an IC50 value of <0.0062 μM for ATM enzyme. It shows adequate selectivity over ATR and also has high cell permeability. Learn More
  19. AZ31

    Catalog No. A16813
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    ATM inhibitor
    AZ31 is a selective and novel ATM inhibitor with an IC50 of <0.0012 μM. It shows excellent selectivity over closely related enzymes (>500 fold selective over DNA-PK and PI3Kα and >1000 fold selective over mTOR, PI3Kβ and PI3Kγ). Learn More
  20. AZD1390

    Catalog No. A16798
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    ATM inhibitor
    AZD1390 is a first-in-class orally available and CNS penetrant ATM inhibitor with an IC50 of 0.78 nM in cells and >10,000-fold selectivity over closely related members of the PIKK family of enzymes and excellent selectivity across a broad panel of kinases. Learn More

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