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- Naltrexone is an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence.
- Heparin, also known as unfractionated heparin, a highly sulfated glycosaminoglycan, is widely used as an injectable anticoagulant, and has the highest negative charge density of any known biological molecule.
- Geniposide is an iridoid glycoside with a variety of biological activities including neuroprotective, anti-diabetic, antiproliferative, and antioxidative activity.
- Atracurium besylate is a neuromuscular blocking agent with ED95 of 0.2 mg/kg.
- Azacyclonol, also known as γ-pipradol, is a drug used to diminish hallucinations in psychotic individuals.
- Articaine is a dental local anesthetic which contains an additional ester group that is metabolized by estearases in blood and tissue.
- Altrenogest is a progestogen structurally related to veterinary steroid trenbolone.
- ENOblock (AP-III-a4) is a novel small molecule which is the first, nonsubstrate analogue that directly binds to enolase and inhibits its activity (IC50=0.576 uM); inhibit cancer cell metastasis in vivo.
- Rachel Polcyn, .et al. , Neurochem Int, 2020, Jul 7;104788 PMID: 32650031
- Yakarsonmez S, .et al. , Mol Divers, 2019, Nov 21 PMID: 31754915
- Ibandronate sodium is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis.
- Levosimendan is a Ca2+ sensitizer that increases contractile force of the myocardium by enhancing the sensitivity of myofilaments to calcium without increasing intracellular calcium concentration.
- Nadifloxacin is a cell-permeable, synthetic, broad-spectrum fluoroquinolone antibiotic that inhibits the growth of both gram-positive and gram-negative microbes.
- Moxalactam is a synthetically derived, structurally unique beta-lactam antibiotic. Its antimicrobial activity encompasses a wide spectrum and includes some strains of pseudomonal species.
- Carnosic acid is a diterpene compound exhibiting antioxidative, anticancer, anti-angiogenic, anti-inflammatory, anti-metabolic disorder, and hepatoprotective and neuroprotective activities.
- (2-Hydroxypropyl)-β-cyclodextrin is a widely used drug delivery vehicle to improve the stability and bioavailability.
- Butylphthalide is an antioxidant and one of the chemical constituents in celery oil, along with sedanolide, which is primarily responsible for the aroma and taste of celery.
- Dimethyl 4-hydroxyisophthalate is a methyl salicylate analogue.
- Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog which can be intercalated into membrane phospholipids without being oxidized or hydrolyzed.
- Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobin tetramer and decreasing hemoglobin-oxygen binding affinity.
- Halofuginone is a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities.
- Satoshi Endo, .et al. , J Biochem, 2021, Mar 17 PMID: 33729485
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fast-skeletal-troponin activator
Tirasemtiv amplifies skeletal muscle response to nerve activation in humans. - Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors.
- Pyronaridine Tetraphosphate is a common antimalarial agent that has been found to enhance the antitumor activity of doxorubicin against multidrug-resistant cancers K562/A02 and MCF-7/ADR.
- Vancomycin is a glycopeptide antibiotic used in the prophylaxis and treatment of infections caused by Gram-positive bacteria
- Viktoria Lazar, .et al. , Nature, 2022, 610: 540-546 PMID: 36198788
- Zewen Wen, .et al. , J Antibiot (Tokyo), 2022, Sep;75(9):498-508 PMID: 35896611
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synthesized plant gowth regulator
Prohydrojasmon racemate is a synthesized plant gowth regulator. - Tirapazamine is a bioreductive, anti-neoplastic, anti-cancer agent that is selectively toxic to cells under hypoxic conditions.
- Zhu R, .et al. , Biomacromolecules, 2019, May 24 PMID: 31125209
- Ibutamoren mesylate (MK-0677) is an orally active nonpeptide growth hormone (GH) secretagogue.
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Histone-H2A peptide
Histone H2A is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. - Sapacitabine is an orally bioavailable pyrimidine analogue prodrug with potential antineoplastic activity.
- Sally L George, .et al. , EBioMedicine, 2020, Aug 23;59:102971 PMID: 32846370
- D2PM (hydrochloride) is a psychoactive designer drug that has recently been demonstrated to have toxic effects in humans.
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O-GlcNAcase inhibitor
Thiamet G is a potent, selective O-GlcNAcase inhibitor with Kiof 21 nM, while exhibiting 37,000-fold selectivity over human lysosomal-hexosaminidase.- Kefan Wu, .et al. , Biomedicines, 2023, Apr 24;11(5):1259 PMID: 37238930
- Wei Zhong Zhu, .et al. , PLoS One, 2022, Oct 26;17(10):e0276285 PMID: 36288343
- Zhu WZ, .et al. , J Am Heart Assoc, 2019, Jun 4;8(11):e011260 PMID: 31131693