Pim

Catalog No.Inhibitor Name Pim1Pim2Pim3Other
A10838SGI-1776 free base
***
*
*
FLT3
A11945SMI-4a
**
A14275CX-6258 HCl
***
**
**
A13203AZD1208
****
***
****
A11967TCS PIM-1 4a
**
*
A12896CX-6258
***
**
**
A15368PIM-1 Inhibitor 2
*
A15369TCS PIM-1 1
*

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. AZD1208

    Catalog No. A13203
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    pan-Pim kinase inhibitor
    AZD1208 is orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity. Learn More
  2. SGI-1776 (free base)

    Catalog No. A10838
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    PIM1 Inhibitor
    SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. Phase 1. Learn More
  3. LGB-321 HCl

    Catalog No. A14420
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    Pan-PIM kinase inhibitor
    LGB-321 HCl is a potent and selective ATP-competitive small molecule inhibitor of PIM kinases (Pan-PIM kinase inhibitor). Learn More
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    SMI-16a

    Catalog No. A17157
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    Pim kinase inhibitor
    SMI-16a is a selective Pim kinase inhibitor with IC50 values of 0.15, 0.02 and 48 μM for Pim1, Pim2 and PC3 cells, respectively. Learn More
  4. (Z)-SMI-4a

    Catalog No. A11945
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    Pim Inhibitor
    SIM-4a is a Pim kinase inhibitor that blocks mTORC1 activity via activation of AMPK. Mostly potent to Pim-2, does not significantly inhibit any other serine/threonine- or tyrosine-kinases. Learn More
  5. AZD1208 HCl

    Catalog No. A16927
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    PIM kinases inhibitor
    AZD1208 hydrochloride is a novel, orally bioavailable, highly selective PIM kinases inhibitor. Learn More
  6. PIM447 (LGH447)

    Catalog No. A16807
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    Pim inhibitor
    PIM447 is a novel pan-PIM kinase inhibitor with Ki values of 6 pM, 18 pM, 9 pM for PIM1, PIM2, PIM3 respectively. It also inhibits GSK3β, PKN1, and PKCτ, but at a significantly lower potency with IC50 between 1 and 5 μM (>105-fold differential relative to the Ki on PIMs). Learn More
  7. TCS PIM-1 1

    Catalog No. A15369
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    Pim-1 Kinase Inhibitor
    TCS PIM-1 1 is a potent and selective ATP-competitive Pim-1 kianse inhibitor with IC50 of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2(IC50s >20,000 nM). Learn More
  8. PIM-1 Inhibitor 2

    Catalog No. A15368
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    PIM-1 Inhibitor
    PIM-1 inhibitor 2 is a potent Pim-1 kinase inhibitor (Ki = 91 nM). Learn More
  9. CX-6258 hydrochloride hydrate

    Catalog No. A15055
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    Pim Inhibitor
    CX-6258 hydrochloride hydrate is a potent, orally efficacious Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor with excellent biochemical potency and kinase selectivity. Learn More
  10. CX-6258 HCl

    Catalog No. A14275
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    Pan-PIM kinase inhibitor
    CX-6258 HCl is a potent, orally efficacious pan-Pim kinase inhibitor with IC50 of 5 nM, 25 nM and 16 nM for Pim1, Pim2, and Pim3. Learn More
  11. CX-6258

    Catalog No. A12896
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    Pim Inhibitor
    CX-6258 is a potent, selective, and orally efficacious pan-Pim kinases inhibitor. Learn More
  12. TCS PIM-1 4a (SMI-4a)

    Catalog No. A11967
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    Pim inhibitor
    TCS PIM-1 4a is a selective and ATP-competitive Pim kinase inhibitor (IC50 values = 24 and 100 nM for Pim-1 and Pim-2, respectively). Learn More

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