PLK

Catalog No.Inhibitor Name PLK1PLK2PLK3Other
A10134BI 2536
****
**
**
PI3Kα,Met,Tie-2
A10135Volasertib
****
A10673Rigosertib
**
A10442GSK461364
***
A12429MLN0905
***
A13245Ro3280
**
A14426SBE 13 HCl
****
*
A13045NMS-P937
***
A10452HMN-214
A11146TAK-960
****
**
*
A11438GW843682X
***
**

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. BI 2536

    Catalog No. A10134
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    PLK inhibitor
    BI 2536 is a selective inhibitor of Plk1, which inhibits Plk1 enzyme activity at low nanomolar concentrations. Learn More
  2. Mps1-IN-2

    Catalog No. A22039
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    dual Mps1/Plk1 inhibitor
    Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor, with an IC50 and a Kd of 145 nM and 12 nM for Mps1 and a Kd of 61 nM for Plk1. Learn More
  3. TC-S 7005

    Catalog No. A19952
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    Plk inhibitor
    TC-S 7005 is a Polo-like kinases (Plks) inhibitor with IC50s of 4 nM, 24 nM and 214 nM for Plk2, Plk3, and Plk1, respectively. Learn More
  4. TAK-960 hydrochloride

    Catalog No. A21703
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    PLK1 inhibitor
    TAK-960 hydrochloride is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC50 of 0.8 nM at 10 μM ATP; TAK-960 hydrochloride also shows inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 and 50.2 nM, respectively. Learn More
  5. SBE13

    Catalog No. A21696
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    Plk1 inhibitor
    SBE13 is a potent and selective Plk1 inhibitor, with an IC50 of 200 pM; SBE13 poorly inhibits Plk2 (IC50>66?μM) or Plk3 (IC50=875?nM). Learn More
  6. Centrinone

    Catalog No. A20858
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    PLK4 inhibitor
    Centrinone (LCR-263) is a selective and reversible inhibitor of polo-like kinase 4 (PLK4) with a Ki of 0.16 nM. Learn More
  7. Centrinone-B

    Catalog No. A20855
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    PLK4 inhibitor
    Centrinone-B (LCR-323) is a potent and highly selective PLK4 inhibitor, with a Ki of 0.59 nM. Learn More
  8. Poloxin

    Catalog No. A11524
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    PLK1 inhibitor
    Poloxin is a non-ATP competitive Polo-like Kinase 1 (PLK1) inhibitor that targets the polo-box domain, with an IC50 of appr 4.8 μM. Learn More
  9. CFI-400945

    Catalog No. A22256
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    PLK4 inhibitor
    CFI-400945 is an orally active, potent and selective polo-like kinase 4(PLK4) inhibitor with Ki value of 0.26 nM. Learn More
  10. GW843682X

    Catalog No. A11438
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    PLK1/PLK3 inhibitor
    GW843682X is a selective inhibitor of polo-like kinase 1 (PLK1) and polo-like kinase 3 (PLK3) (IC50 values are 2.2 and 9.1 nM respectively). Learn More
  11. BI6727 (Volasertib)

    Catalog No. A10135
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    PLK Inhibitor
    BI6727 is a highly potent and selective polo-like kinase (PLK) 1 inhibitor (enzyme IC50 = 0.87 nM, EC50 = 11-37 nM on a panel of cancer cell lines). Learn More
  12. GSK461364

    Catalog No. A10442
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    PLK Inhibitor
    GSK461364 is an ATP-competitive inhibitor of polo-like kinase 1 (Plk1). Learn More
  13. HMN-214

    Catalog No. A10452
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    PLK Inhibitor
    HMN-214 inhibits polo-like and cyclin-dependent kinase activity, has potent antimicrotubular effects and results in profound apoptosis and antitumor activity in a broad spectrum of human xenografts. Learn More
  14. TAK-960

    Catalog No. A11146
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    PLK1 inhibitor‎
    TAK-960 is a novel, orally available, selective inhibitor of polo-like kinase 1, shows broad-spectrum preclinical antitumor activity. Learn More
  15. ON-01910 (rigosertib)

    Catalog No. A10673
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    PLK Inhibitor
    ON-01910 is selectively cytotoxic for chronic lymphocytic leukemia cells through a dual mechanism of action involving PI3K/AKT inhibition and induction of oxidative stress. Learn More
  16. NMS-1286937

    Catalog No. A13045
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    PLK inhibitor
    NMS-1286937 is an orally bioavailable, small-molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Learn More
  17. MLN 0905

    Catalog No. A12429
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    PLK1 inhibitor
    MLN0905 is a potent, selective small-molecule PLK1 inhibitor. MLN0905 inhibits cell proliferation in a broad range of human tumor cells including DLBCL cell lines. Learn More
  18. Poloxime

    Catalog No. A12145
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    PLK1 inhibitor
    Poloxime, a hydrolysis product of poloxin, is a non-ATP-competitive Plk1 inhibitor, with moderate Plk1 inhibitory activity. Learn More
  19. AAPK-25

    Catalog No. A19085
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    Aurora/PLK dual inhibitor
    AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in a prometaphase, reflecting by the biomarker histone H3Ser10 phosphorylation and followed by a surge in apoptosis. Learn More
  20. RO3280

    Catalog No. A13245
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    PLK1 inhibitor
    RO3280 is a potent, highly selective inhibitor of Polo-like kinase 1 (PLK1) with IC50 of 3 nM. Learn More
  21. SBE 13 HCl

    Catalog No. A14426
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    PLK inhibitor
    SBE 13 HCl is a selective inhibitor of PLK1 (IC50 values are 200 pM, 875 nM and 66 μM for PLK1, PLK3 and PLK2 respectively). Learn More
  22. LFM-A13

    Catalog No. A16261
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    BTK inhibitor
    LFM-A13 is a potent and selective inhibitor of Btk with IC50 of 17.2 uM; also inhibits PLK3 with IC50 of 7.2 uM. Learn More

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