PLK

Catalog No.Inhibitor Name PLK1PLK2PLK3Other
A10134BI 2536
****
**
**
PI3Kα,Met,Tie-2
A10135Volasertib
****
A10673Rigosertib
**
A10442GSK461364
***
A12429MLN0905
***
A13245Ro3280
**
A14426SBE 13 HCl
****
*
A13045NMS-P937
***
A10452HMN-214
A11146TAK-960
****
**
*
A11438GW843682X
***
**

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. BI 2536

    Catalog No. A10134
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    PLK inhibitor
    BI 2536 is a selective inhibitor of Plk1, which inhibits Plk1 enzyme activity at low nanomolar concentrations. Learn More
  2. SBE 13 HCl

    Catalog No. A14426
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    PLK inhibitor
    SBE 13 HCl is a selective inhibitor of PLK1 (IC50 values are 200 pM, 875 nM and 66 μM for PLK1, PLK3 and PLK2 respectively). Learn More
  3. NMS-1286937

    Catalog No. A13045
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    PLK inhibitor
    NMS-1286937 is an orally bioavailable, small-molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Learn More
  4. RO3280

    Catalog No. A13245
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    PLK1 inhibitor
    RO3280 is a potent, highly selective inhibitor of Polo-like kinase 1 (PLK1) with IC50 of 3 nM. Learn More
  5. MLN 0905

    Catalog No. A12429
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    PLK1 inhibitor
    MLN0905 is a potent, selective small-molecule PLK1 inhibitor. MLN0905 inhibits cell proliferation in a broad range of human tumor cells including DLBCL cell lines. Learn More
  6. GW843682X

    Catalog No. A11438
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    PLK1/PLK3 inhibitor
    GW843682X is a selective inhibitor of polo-like kinase 1 (PLK1) and polo-like kinase 3 (PLK3) (IC50 values are 2.2 and 9.1 nM respectively). Learn More
  7. ON-01910 (rigosertib)

    Catalog No. A10673
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    PLK Inhibitor
    ON-01910 is selectively cytotoxic for chronic lymphocytic leukemia cells through a dual mechanism of action involving PI3K/AKT inhibition and induction of oxidative stress. Learn More
  8. BI6727 (Volasertib)

    Catalog No. A10135
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    PLK Inhibitor
    BI6727 is a highly potent and selective polo-like kinase (PLK) 1 inhibitor (enzyme IC50 = 0.87 nM, EC50 = 11-37 nM on a panel of cancer cell lines). Learn More
  9. TAK-960

    Catalog No. A11146
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    PLK1 inhibitor‎
    TAK-960 is a novel, orally available, selective inhibitor of polo-like kinase 1, shows broad-spectrum preclinical antitumor activity. Learn More
  10. HMN-214

    Catalog No. A10452
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    PLK Inhibitor
    HMN-214 inhibits polo-like and cyclin-dependent kinase activity, has potent antimicrotubular effects and results in profound apoptosis and antitumor activity in a broad spectrum of human xenografts. Learn More
  11. GSK461364

    Catalog No. A10442
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    PLK Inhibitor
    GSK461364 is an ATP-competitive inhibitor of polo-like kinase 1 (Plk1). Learn More
  12. LFM-A13

    Catalog No. A16261
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    BTK inhibitor
    LFM-A13 is a potent and selective inhibitor of Btk with IC50 of 17.2 uM; also inhibits PLK3 with IC50 of 7.2 uM. Learn More

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