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| Catalog No. | Inhibitor Name | PLK1 | PLK2 | PLK3 | Other |
|---|---|---|---|---|---|
| A10134 | BI 2536 | **** | ** | ** | PI3Kα,Met,Tie-2 |
| A10135 | Volasertib | **** | |||
| A10673 | Rigosertib | ** | |||
| A10442 | GSK461364 | *** | |||
| A12429 | MLN0905 | *** | |||
| A13245 | Ro3280 | ** | |||
| A14426 | SBE 13 HCl | **** | * | ||
| A13045 | NMS-P937 | *** | |||
| A10452 | HMN-214 | ||||
| A11146 | TAK-960 | **** | ** | * | |
| A11438 | GW843682X | *** | ** |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
22 Item(s)
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CFI-400945
Catalog No. A22256 PLK4 inhibitorCFI-400945 is an orally active, potent and selective polo-like kinase 4(PLK4) inhibitor with Ki value of 0.26 nM. Learn More -
Mps1-IN-2
Catalog No. A22039 dual Mps1/Plk1 inhibitorMps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor, with an IC50 and a Kd of 145 nM and 12 nM for Mps1 and a Kd of 61 nM for Plk1. Learn More -
TC-S 7005
Catalog No. A19952 Plk inhibitorTC-S 7005 is a Polo-like kinases (Plks) inhibitor with IC50s of 4 nM, 24 nM and 214 nM for Plk2, Plk3, and Plk1, respectively. Learn More -
BI6727 (Volasertib)
Catalog No. A10135 PLK InhibitorBI6727 is a highly potent and selective polo-like kinase (PLK) 1 inhibitor (enzyme IC50 = 0.87 nM, EC50 = 11-37 nM on a panel of cancer cell lines). Learn More -
TAK-960 hydrochloride
Catalog No. A21703 PLK1 inhibitorTAK-960 hydrochloride is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC50 of 0.8 nM at 10 μM ATP; TAK-960 hydrochloride also shows inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 and 50.2 nM, respectively. Learn More -
GW843682X
Catalog No. A11438 PLK1/PLK3 inhibitorGW843682X is a selective inhibitor of polo-like kinase 1 (PLK1) and polo-like kinase 3 (PLK3) (IC50 values are 2.2 and 9.1 nM respectively). Learn More -
SBE13
Catalog No. A21696 Plk1 inhibitorSBE13 is a potent and selective Plk1 inhibitor, with an IC50 of 200 pM; SBE13 poorly inhibits Plk2 (IC50>66?μM) or Plk3 (IC50=875?nM). Learn More -
Centrinone
Catalog No. A20858 PLK4 inhibitorCentrinone (LCR-263) is a selective and reversible inhibitor of polo-like kinase 4 (PLK4) with a Ki of 0.16 nM. Learn More -
Centrinone-B
Catalog No. A20855 PLK4 inhibitorCentrinone-B (LCR-323) is a potent and highly selective PLK4 inhibitor, with a Ki of 0.59 nM. Learn More -
Poloxin
Catalog No. A11524 PLK1 inhibitorPoloxin is a non-ATP competitive Polo-like Kinase 1 (PLK1) inhibitor that targets the polo-box domain, with an IC50 of appr 4.8 μM. Learn More -
BI 2536
Catalog No. A10134 PLK inhibitorBI 2536 is a selective inhibitor of Plk1, which inhibits Plk1 enzyme activity at low nanomolar concentrations. Learn More -
LFM-A13
Catalog No. A16261 BTK inhibitorLFM-A13 is a potent and selective inhibitor of Btk with IC50 of 17.2 uM; also inhibits PLK3 with IC50 of 7.2 uM. Learn More -
Poloxime
Catalog No. A12145 PLK1 inhibitorPoloxime, a hydrolysis product of poloxin, is a non-ATP-competitive Plk1 inhibitor, with moderate Plk1 inhibitory activity. Learn More -
AAPK-25
Catalog No. A19085 Aurora/PLK dual inhibitorAAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in a prometaphase, reflecting by the biomarker histone H3Ser10 phosphorylation and followed by a surge in apoptosis. Learn More -
SBE 13 HCl
Catalog No. A14426 PLK inhibitorSBE 13 HCl is a selective inhibitor of PLK1 (IC50 values are 200 pM, 875 nM and 66 μM for PLK1, PLK3 and PLK2 respectively). Learn More -
NMS-1286937
Catalog No. A13045 PLK inhibitorNMS-1286937 is an orally bioavailable, small-molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Learn More -
RO3280
Catalog No. A13245 PLK1 inhibitorRO3280 is a potent, highly selective inhibitor of Polo-like kinase 1 (PLK1) with IC50 of 3 nM. Learn More -
MLN 0905
Catalog No. A12429 PLK1 inhibitorMLN0905 is a potent, selective small-molecule PLK1 inhibitor. MLN0905 inhibits cell proliferation in a broad range of human tumor cells including DLBCL cell lines. Learn More -
ON-01910 (rigosertib)
Catalog No. A10673 PLK InhibitorON-01910 is selectively cytotoxic for chronic lymphocytic leukemia cells through a dual mechanism of action involving PI3K/AKT inhibition and induction of oxidative stress. Learn More -
TAK-960
Catalog No. A11146 PLK1 inhibitorTAK-960 is a novel, orally available, selective inhibitor of polo-like kinase 1, shows broad-spectrum preclinical antitumor activity. Learn More -
HMN-214
Catalog No. A10452 PLK InhibitorHMN-214 inhibits polo-like and cyclin-dependent kinase activity, has potent antimicrotubular effects and results in profound apoptosis and antitumor activity in a broad spectrum of human xenografts. Learn More -
GSK461364
Catalog No. A10442 PLK InhibitorGSK461364 is an ATP-competitive inhibitor of polo-like kinase 1 (Plk1). Learn More
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