Stat

Catalog No.Inhibitor Name STAT1STAT3STAT5Other
A10817S3I-201
*
A12733Stattic
**
A14249SH-4-54
****
****
A10244Cryptotanshinone
**
A10396Fludarabine
A16220Nifuroxazide
A13474Napabucasin
A15363Cucurbitacin I
JAK2
A15364SD 1008
JAK2
A15366ZM 449829
JAK3, EGFR, JAK1, CDK4
A15729Corylifol A
*
A15885HO-3867
A10087Artesunate
EXP1(a membrane glutathione S-transferase)

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

21 Item(s)

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  1. Nitidine chloride

    Catalog No. A14701
    STAT inhibitor
    Nitidine chloride, a natural benzophenanthridine alkaloid, has been shown to inhibit cancer growth via induction of cell apoptosis and suppression of cancer angiogenesis. Learn More
  2. SD 1008

    Catalog No. A15364
    JAK2/STAT3 inhibitor
    SD 1008 is reported to be a JAK2/STAT3 signaling pathway inhibitor which additionally inhibits Src. SD 1008 is noted to induce apoptosis in cell lines that express constitutively active tyrosine-phosphorylated STAT3. Learn More
  3. ZM 449829

    Catalog No. A15366
    JAK/STAT inhibitor
    JAK3 Inhibitor V is a potent, selective inhibitor of JAK3 (Janus tyrosine kinase 3) which binds competitively to the JAK3 ATP site. Learn More
  4. STA-21

    Catalog No. A15885
    STAT-3 inhibitor
    STA-21 is a promising STAT-3 inhibitor that reciprocally regulates Th17 and Treg cells, inhibits osteoclastogenesis in mice and humans and alleviates autoimmune inflammation in an experimental model of rheumatoid arthritis. Learn More
  5. Corylifol A

    Catalog No. A15729
    STAT3 inhibitor
    Corylifol A is a phenolic compounds isolated from Psoralea corylifolia; inhibits IL-6-induced STAT3 activation and phosphorylation(IC50=0.8 uM). Learn More
  6. Nifuroxazide

    Catalog No. A16220
    STAT inhibitor
    Nifuroxazide is an inhibitor of STAT activation and signaling activity, is an oral nitrofuran antibiotic, used to treat colitis and diarrhea in humans and non-humans. Learn More
  7. Cucurbitacin I

    Catalog No. A15363
    JAK2/STAT3 inhibitor
    Cucurbitacin I, Cucumis sativus L. has been found to suppress levels of phosphotyrosine Stat3 (signal transducer and activator of transcription 3) in v-Src-transformed NIH 3T3 cells. Learn More
  8. Napabucasin

    Catalog No. A13474
    STAT inhibitor
    Napabucasin is an orally-administered small molecule which can block cancer stem cell (CSC) self-renewal and induces cell death in CSCs as well as non-stem cancer cells. Learn More
  9. HJC0152

    Catalog No. A16806
    STAT3 inhibitor
    HJC0152 is a STAT3 inhibitor with remarkably improved aqueous solubility. Learn More
  10. C188-9

    Catalog No. A16804
    STAT3 inhibitor
    C188-9 is a potent inhibitor of STAT3 that binds to STAT3 with high affinity (KD=4.7±0.4 nM). C188-9 is well tolerated in mice, shows good oral bioavailability, and is concentrated in tumors. Learn More
  11. S3I-201 (NSC 74859)

    Catalog No. A10817
    Stat3 Inhibitor
    S3I-201 (NSC 74859) is a novel inhibitor of Stat3 that inhibits Stat3, Stat3 complex formation and Stat3-DNA binding activity in vitro (IC50 = 86 ± 33 µM) and Stat3-dependent transcriptional activities. Learn More
  12. Homoharringtonine

    Catalog No. A14490
    Stat3 inhibitor & Apoptosis inducer
    Homoharringtonine is a cephalotaxine alkaloid which inhibits the formation of diphenylalanine and acetylphenylalanyl-puromycin in liver ribosomes. Learn More
  13. Artesunate

    Catalog No. A10087
    cytochrome oxidase inhibitor
    Artesunate is a semisynthetic derivative of artemisinin used to treat malaria. It has also been shown to effective against other parasites such as liver flukes. Artesunate also demonstrates cytotoxic action against cancer cell lines of different tumor types. Artesunate has been shown to inhibit TNF--induced production of proinflammatory cytokines via inhibition of NF-B and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes.
    Learn More
  14. Cryptotanshinone

    Catalog No. A10244
    Stat3 inhibitor
    Cryptotanshinone, a natural compound isolated from the roots of Salvia miltiorrhiza Bunge (Danshen), dramatically blocks STAT3 Tyr705 phosphorylation but not STAT3 Ser727 phosphorylation in DU145 cells, and significantly inhibits JAK2 phosphorylation with IC50 of ~5 μM without affecting the phosphorylation of upstream kinases c-Src and EGFR. Learn More
  15. Fludarabine or fludarabine phosphate (Fludara) is a chemotherapy drug used in the treatment of hematological malignancies (cancers of blood cells such as leukemias and lymphomas) .Fludarabine inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase. It is active against both dividing and resting cells. Learn More
  16. Fludarabine (Fludara)

    Catalog No. A10396
    STAT inhibitor
    Fludarabine or fludarabine phosphate (Fludara) is a chemotherapy drug used in the treatment of hematological malignancies (cancers of blood cells such as leukemias and lymphomas) .Fludarabine inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase. It is active against both dividing and resting cells. Learn More
  17. HO-3867

    Catalog No. A14264
    STAT3 inhibitor
    HO-3867 is a selective STAT3 inhibitor. Learn More
  18. SH-4-54

    Catalog No. A14249
    Stat inhibitor
    SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5. Learn More
  19. Stattic

    Catalog No. A12733
    STAT3 inhibitor
    Stattic is a small molecule shown to selectively inhibit the activation of the Stat3 transcription factor by blocking phosphorylation and dimerization events. Learn More
  20. STAT5 Inhibitor

    Catalog No. A13628
    STAT Inhibitor
    STAT5 Inhibitor is a cell-permeable, nonpetidic nicotinoyl hydrazone that suppresses STAT5 by targeting its SH2 domain (IC50 = 47 μM against STAT5?? SH2 domain EPO peptide binding activity). Learn More
  21. AS-1517499

    Catalog No. A16802
    STAT6 inhibitor
    AS1517499 is a novel and potent STAT6 inhibitor with an IC50 value of 21 nM. Learn More

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