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| Catalog No. | Inhibitor Name | STAT1 | STAT3 | STAT5 | Other |
|---|---|---|---|---|---|
| A10817 | S3I-201 | * | |||
| A12733 | Stattic | ** | |||
| A14249 | SH-4-54 | **** | **** | ||
| A10244 | Cryptotanshinone | ** | |||
| A10396 | Fludarabine | ||||
| A16220 | Nifuroxazide | ||||
| A13474 | Napabucasin | ||||
| A15363 | Cucurbitacin I | JAK2 | |||
| A15364 | SD 1008 | JAK2 | |||
| A15366 | ZM 449829 | JAK3, EGFR, JAK1, CDK4 | |||
| A15729 | Corylifol A | * | |||
| A15885 | HO-3867 | ||||
| A10087 | Artesunate | EXP1(a membrane glutathione S-transferase) |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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SD 1008
Catalog No. A15364 JAK2/STAT3 inhibitorSD 1008 is reported to be a JAK2/STAT3 signaling pathway inhibitor which additionally inhibits Src. SD 1008 is noted to induce apoptosis in cell lines that express constitutively active tyrosine-phosphorylated STAT3. Learn More -
Cucurbitacin I
Catalog No. A15363 JAK2/STAT3 inhibitorCucurbitacin I, Cucumis sativus L. has been found to suppress levels of phosphotyrosine Stat3 (signal transducer and activator of transcription 3) in v-Src-transformed NIH 3T3 cells. Learn More -
Nitidine chloride
Catalog No. A14701 STAT inhibitorNitidine chloride, a natural benzophenanthridine alkaloid, has been shown to inhibit cancer growth via induction of cell apoptosis and suppression of cancer angiogenesis. Learn More -
STA-21
Catalog No. A15885 STAT-3 inhibitorSTA-21 is a promising STAT-3 inhibitor that reciprocally regulates Th17 and Treg cells, inhibits osteoclastogenesis in mice and humans and alleviates autoimmune inflammation in an experimental model of rheumatoid arthritis. Learn More -
Corylifol A
Catalog No. A15729 STAT3 inhibitorCorylifol A is a phenolic compounds isolated from Psoralea corylifolia; inhibits IL-6-induced STAT3 activation and phosphorylation(IC50=0.8 uM). Learn More -
Nifuroxazide
Catalog No. A16220 STAT inhibitorNifuroxazide is an inhibitor of STAT activation and signaling activity, is an oral nitrofuran antibiotic, used to treat colitis and diarrhea in humans and non-humans. Learn More -
ZM 449829
Catalog No. A15366 JAK/STAT inhibitorJAK3 Inhibitor V is a potent, selective inhibitor of JAK3 (Janus tyrosine kinase 3) which binds competitively to the JAK3 ATP site. Learn More -
HJC0152
Catalog No. A16806 STAT3 inhibitorHJC0152 is a STAT3 inhibitor with remarkably improved aqueous solubility. Learn More -
C188-9
Catalog No. A16804 STAT3 inhibitorC188-9 is a potent inhibitor of STAT3 that binds to STAT3 with high affinity (KD=4.7±0.4 nM). C188-9 is well tolerated in mice, shows good oral bioavailability, and is concentrated in tumors. Learn More -
AS-1517499
Catalog No. A16802 STAT6 inhibitorAS1517499 is a novel and potent STAT6 inhibitor with an IC50 value of 21 nM. Learn More -
Napabucasin
Catalog No. A13474 STAT inhibitorNapabucasin is an orally-administered small molecule which can block cancer stem cell (CSC) self-renewal and induces cell death in CSCs as well as non-stem cancer cells. Learn More -
AC-4-130
Catalog No. A18314 STAT5 SH2 domain inhibitorAC-4-130 is a novel, potent STAT5 SH2 domain inhibitor, binds to and efficiently blocks STAT5 activation and subsequent transcriptional activity, shows high selectivity for STAT5 over STAT1 and STAT3. Learn More -
STAT3-IN-3
Catalog No. A18479 STAT3 inhibitorSTAT3-IN-3 is a potent and selective inhibitor of signal transducer and activator of transcription 3 (STAT3). Learn More -
S3I-201 (NSC 74859)
Catalog No. A10817 Stat3 InhibitorS3I-201 (NSC 74859) is a novel inhibitor of Stat3 that inhibits Stat3, Stat3 complex formation and Stat3-DNA binding activity in vitro (IC50 = 86 ± 33 µM) and Stat3-dependent transcriptional activities. Learn More -
Artesunate
Catalog No. A10087 cytochrome oxidase inhibitorArtesunate is a semisynthetic derivative of artemisinin used to treat malaria. It has also been shown to effective against other parasites such as liver flukes. Artesunate also demonstrates cytotoxic action against cancer cell lines of different tumor types. Artesunate has been shown to inhibit TNF--induced production of proinflammatory cytokines via inhibition of NF-B and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes.Learn More -
Cryptotanshinone
Catalog No. A10244 Stat3 inhibitorCryptotanshinone, a natural compound isolated from the roots of Salvia miltiorrhiza Bunge (Danshen), dramatically blocks STAT3 Tyr705 phosphorylation but not STAT3 Ser727 phosphorylation in DU145 cells, and significantly inhibits JAK2 phosphorylation with IC50 of ~5 μM without affecting the phosphorylation of upstream kinases c-Src and EGFR. Learn More -
Fludarabine Phosphate (Fludara)
Catalog No. A10395 Fludarabine or fludarabine phosphate (Fludara) is a chemotherapy drug used in the treatment of hematological malignancies (cancers of blood cells such as leukemias and lymphomas) .Fludarabine inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase. It is active against both dividing and resting cells. Learn More -
Fludarabine (Fludara)
Catalog No. A10396 STAT inhibitorFludarabine or fludarabine phosphate (Fludara) is a chemotherapy drug used in the treatment of hematological malignancies (cancers of blood cells such as leukemias and lymphomas) .Fludarabine inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase. It is active against both dividing and resting cells. Learn More -
HO-3867
Catalog No. A14264 -
SH-4-54
Catalog No. A14249 Stat inhibitorSH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5. Learn More -
Stattic
Catalog No. A12733 STAT3 inhibitorStattic is a small molecule shown to selectively inhibit the activation of the Stat3 transcription factor by blocking phosphorylation and dimerization events. Learn More -
STAT5 Inhibitor
Catalog No. A13628 STAT InhibitorSTAT5 Inhibitor is a cell-permeable, nonpetidic nicotinoyl hydrazone that suppresses STAT5 by targeting its SH2 domain (IC50 = 47 μM against STAT5?? SH2 domain EPO peptide binding activity). Learn More -
Homoharringtonine
Catalog No. A14490 Stat3 inhibitor & Apoptosis inducerHomoharringtonine is a cephalotaxine alkaloid which inhibits the formation of diphenylalanine and acetylphenylalanyl-puromycin in liver ribosomes. Learn More -
STAT3-IN-1
Catalog No. A12232 STAT3 inhibitorSTAT3-IN-1 (compound 7d) is an excellent, selective and orally active STAT3 inhibitor, with IC50 values of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 (compound 7d) induces tumor apoptosis. Learn More
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