United States
You have no items in your shopping cart.
Phosphodiesterases (PDE)
Inhibitory Selectivity
| Catalog No. | Inhibitor Name | PDE | PDE1 | PDE2 | PDE3 | PDE4 | PDE5 | PDE6 | PDE9A | PDE10A | Other |
|---|---|---|---|---|---|---|---|---|---|---|---|
| A10804 | Roflumilast | **** | |||||||||
| A10216 | Cilomilast | *** | |||||||||
| A10883 | Tadalafil | *** | |||||||||
| A10733 | Pimobendan | ** | |||||||||
| A11073 | GSK256066 | **** | |||||||||
| A11191 | PF-2545920 | **** | |||||||||
| A10805 | Rolipram | ** | |||||||||
| A10217 | Cilostazol | ** | |||||||||
| A10592 | Milrinone | ** | ** | ATPase | |||||||
| A12619 | Avanafil | **** | |||||||||
| A10066 | Aminophylline | * | adenosine receptor | ||||||||
| A15799 | TAK-063 | **** | |||||||||
| A13722 | Deltarasin | *** | |||||||||
| A10541 | Luteolin | * | * | * | * | * | |||||
| A10464 | Icariin | ** | mAChR,AChR | ||||||||
| A10480 | Irsogladine | ||||||||||
| A10319 | Dipyridamole | ||||||||||
| A10339 | Dyphylline | ||||||||||
| A11527 | PF-8380 | *** | |||||||||
| A10965 | Vardenafil | *** | **** | ||||||||
| A11019 | Ibudilast (KC-404) | ||||||||||
| A11289 | Apremilast (CC 10004) | *** | |||||||||
| A11326 | Bay 60-7550 | **** | |||||||||
| A11602 | Vinpocetine | Sodium channel | |||||||||
| A12550 | Zardaverine | ** | ** | ||||||||
| A12631 | Sildenafil | *** | *** | ||||||||
| A12776 | AN2728 | *** | |||||||||
| A13121 | PF-04447943 | *** | |||||||||
| A13467 | MK-0359 | ||||||||||
| A13596 | Cilostamide | *** | |||||||||
| A15191 | Nortadalafil | ||||||||||
| A15197 | Oglemilast | **** | |||||||||
| A15198 | Olprinone Hydrochloride |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
| Catalog No. | Product Name | Application | Product Information |
|---|---|---|---|
A10066 SALE |
Aminophylline |
- |
Aminophylline is a nonselective adenosine receptor antagonist and phosphodiesterase inhibitor capable of reversing ischemia-induced bradyasystole.
|
A12776 SALE |
AN2728 |
PDE4 inhibitor |
AN2728 is a topically administered, boron-containing, anti-inflammatory compound that inhibits PDE4 activity and thereby suppresses the release of TNFalpha, IL-12, IL-23 and other cytokines
|
A11289 SALE |
Apremilast (CC 10004) |
PDE4 Inhibitor |
Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis.
|
A12619 |
Avanafil |
PDE5 inhibitor |
Avanafil is a PDE5 Inhibitor for the Treatment of Erectile Dysfunction
|
A11326 |
Bay 60-7550 |
PDE-2 Inhibitor |
BAY 60-7550 is a potent PDE2 inhibitor with IC50 values of 2.0 nM (bovine) and 4.7 nM (human).
|
A10216 |
Cilomilast (SB-207499) |
PDE-4 inhibitor |
Cilomilast is orally active and acts as a selective Phosphodiesterase-4 inhibitor with antiinflammatory effects that target bronchoconstriction, mucus hypersecretion, and airway remodeling associated with COPD.
|
A13596 |
Cilostamide |
PDE3 inhibitor |
Cilostamide is a selective inhibitor of phosphodiesterase (PDE)3A and PDE3B with IC50 values of 27 and 50 nM, respectively.
|
A10217 |
Cilostazol |
PDE3 inhibitor |
Cilostazol is a selective inhibitor of 3-type phosphodiesterase (PDE3) with therapeutic focus on cAMP.
|
A13722 SALE |
Deltarasin HCl |
PDE-KRAS inhibitor |
Deltarasin is a novel small molecule inhibiting the KRAS PDEδ interaction and thus impairing oncogenic KRAS signalling.
|
A10319 |
Dipyridamole |
- |
Dipyridamole (Persantine) is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells.
|
A10339 SALE |
Dyphylline |
- |
Dyphylline is a xanthine derivative with bronchodilator and vasodilator effects. It acts as an adenosine receptor antagonist and phosphodiesterase inhibitor.
|
A11073 |
GSK256066 |
PDE Inhibitor |
GSK256066 is an exceptionally high affinity and selective inhibitor of PDE4 that inhibits PDE4 isoforms A-D with equal affinity and has a high HARBS (High-Affinity Rolipram Binding Site) ratio (>17).
|
A15097 |
GSK256066 2,2,2-trifluoroacetic acid |
PDE Inhibitor |
GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380,000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7.
|
A10449 SALE |
Hesperetin |
PDE4 inhibitor |
Hesperetin, a selective phosphodiesterase (PDE)4 inhibitor, is present in the traditional Chinese medicine, “Chen Pi.” Hesperetin is a citrus flavonoid that has been reported to lower plasma cholesterol. Hesperetin reduces the transcription of ACAT-2 mRNA in Hep-G2 cells and reduces ApoB protein synthesis in a dose-dependent manner. It also is a potential therapy for carcinoid cancer.
|
A11019 SALE |
Ibudilast (KC-404) |
PDE Inhibitor |
Ibudilast, a pharmacologic phosphodiesterase inhibitor, prevents human immunodeficiency Virus-1 Tat-Mediated activation of microglial cells.
|
A10464 SALE |
Icariin |
PDE5 inhibitor |
Icariin is inhibitory to all three PDE5 isoforms that inhibits PDE5A1, A2, and A3 with an IC50 value of 1.0, 0.75, and 1.1 microM, respectively.
|
A10480 SALE |
Irsogladine |
- |
Rsogladine is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding.
|
A10541 SALE |
Luteolin |
PDE4 inhibitor |
Luteolin is a PDE4 inhibitor, phosphodiesterase inhibitor, and an interleukin 6 inhibitor, affecting xylazine/ketamine-induced anesthesia in mice. Luteolin acts as a monoamine transporter activator, and is one of the few chemicals demonstrated to possess this property.
|
A10592 SALE |
Milrinone (Primacor) |
PDE3 inhibitor |
Milrinone(Primacor) is a a potent and selective phosphodiesterase 3 inhibitor with an IC50 of 0.42 μM for the inhibition of FIII PDE
|
A13467 |
MK-0359 |
PDE4 inhibitor |
MK-0359 is a selective and potent oral PDE4 inhibitor, in chronic asthma.
|
A15191 |
Nortadalafil |
PDE5 inhibitor |
Nortadalafil is demethyl Tadalafil, which is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) under the name Cialis; and under the name Adcirca for the treatment of pulmonary arterial hypertension.
|
A15197 |
Oglemilast |
PDE4 inhibitor |
Oglemilast is a potent inhibitor of PDE4.
|
A15198 |
Olprinone Hydrochloride |
PDE3 inhibitor |
Olprinone is a selective phosphodiesterase 3 (PDE3) inhibitor.
|
A13121 |
PF-04447943 |
PDE9 inhibitor |
PF-04447943 is a potent, selective brain penetrant PDE9 inhibitor that increased indicators of hippocampal synaptic plasticity and improved cognitive function in a variety of cognition models in both rats and mice.
|
A11191 SALE |
PF-2545920 |
PDE10A inhibitor |
PF-2545920 is a phosphodiesterase inhibitor selective for the PDE10A subtype. |
