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Phosphodiesterases (PDEs)



21 Item(s)

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Catalog No. Product Name Product Information
A12776

AN2728

AN2728 is a topically administered, boron-containing, anti-inflammatory compound that inhibits PDE4 activity and thereby suppresses the release of TNFalpha, IL-12, IL-23 and other cytokines Learn More
A11289

Apremilast (CC 10004)

Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis. Learn More
A12619

Avanafil

Avanafil is a PDE5 Inhibitor for the Treatment of Erectile Dysfunction Learn More
A11326

Bay 60-7550

BAY 60-7550 is a potent PDE2 inhibitor with IC50 values of 2.0 nM (bovine) and 4.7 nM (human). Learn More
A10216

Cilomilast (SB-207499)

Cilomilast is orally active and acts as a selective Phosphodiesterase-4 inhibitor with antiinflammatory effects that target bronchoconstriction, mucus hypersecretion, and airway remodeling associated with COPD. Learn More
A10217

Cilostazol

Cilostazol is a selective inhibitor of 3-type phosphodiesterase (PDE3) with therapeutic focus on cAMP. Learn More
A13722

Deltarasin HCl

Deltarasin is a novel small molecule inhibiting the KRAS PDEδ interaction and thus impairing oncogenic KRAS signalling. Learn More
A11073

GSK256066

GSK256066 is an exceptionally high affinity and selective inhibitor of PDE4 that inhibits PDE4 isoforms A-D with equal affinity and has a high HARBS (High-Affinity Rolipram Binding Site) ratio (>17). Learn More
A10449

Hesperetin

Hesperetin, a selective phosphodiesterase (PDE)4 inhibitor, is present in the traditional Chinese medicine, “Chen Pi.” Hesperetin is a citrus flavonoid that has been reported to lower plasma cholesterol. Hesperetin reduces the transcription of ACAT-2 mRNA in Hep-G2 cells and reduces ApoB protein synthesis in a dose-dependent manner. It also is a potential therapy for carcinoid cancer. Learn More
A11019

Ibudilast (KC-404)

Ibudilast, a pharmacologic phosphodiesterase inhibitor, prevents human immunodeficiency Virus-1 Tat-Mediated activation of microglial cells. Learn More
A10464

Icariin

Icariin is inhibitory to all three PDE5 isoforms that inhibits PDE5A1, A2, and A3 with an IC50 value of 1.0, 0.75, and 1.1 microM, respectively. Learn More
A10541

Luteolin

Luteolin is a PDE4 inhibitor, phosphodiesterase inhibitor, and an interleukin 6 inhibitor, affecting xylazine/ketamine-induced anesthesia in mice. Luteolin acts as a monoamine transporter activator, and is one of the few chemicals demonstrated to possess this property. Learn More
A10592

Milrinone (Primacor)

Milrinone(Primacor) is a a potent and selective phosphodiesterase 3 inhibitor with an IC50 of 0.42 μM for the inhibition of FIII PDE Learn More
A13121

PF-04447943

PF-04447943 is a potent, selective brain penetrant PDE9 inhibitor that increased indicators of hippocampal synaptic plasticity and improved cognitive function in a variety of cognition models in both rats and mice. Learn More
A11191

PF-2545920

PF-2545920 is a phosphodiesterase inhibitor selective for the PDE10A subtype.

Learn More
A10733

Pimobendan (Vetmedin)

Pimobendan (Vetmedin) is a calcium sensitizer with positive inotropic and vasodilator effects. It is also a selective inhibitor of phosphodiesterase III (PDE3). Learn More
A10804

Roflumilast

Roflumilast acts as a selective, long-acting inhibitor of the enzyme PDE-4. Learn More
A10805

Rolipram

Rolipram is a PDE4-inhibitor with IC50 = 2.0 μM. Learn More
A10883

Tadalafil

Tadalafil is a PDE5 inhibitor with an IC50 value of 1.8 nM. Learn More
A10965

Vardenafil

Vardenafil is a PDE5 inhibitor used for treating erectile dysfunction. Learn More
A12550

Zardaverine

Zardaverine is a phosphodiesterase inhibitor, selective for PDE3 and 4 (IC50 values are 0.5 and 0.8 ??M respectively). Learn More

21 Item(s)

per page

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Phosphodiesterases (PDEs)

Minimal Price: $40.00