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Phosphodiesterases (PDEs)
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- Inhibitor (22)
25 Item(s)
per page
| Catalog No. | Product Name | Product Information |
|---|---|---|
A12776 |
AN2728 |
AN2728 is a topically administered, boron-containing, anti-inflammatory compound that inhibits PDE4 activity and thereby suppresses the release of TNFalpha, IL-12, IL-23 and other cytokines Learn More
|
A11289 |
Apremilast (CC 10004) |
Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis. Learn More
|
A11326 |
Bay 60-7550 |
BAY 60-7550 is a potent PDE2 inhibitor with IC50 values of 2.0 nM (bovine) and 4.7 nM (human). Learn More
|
A10216 |
Cilomilast (SB-207499) |
Cilomilast is orally active and acts as a selective Phosphodiesterase-4 inhibitor with antiinflammatory effects that target bronchoconstriction, mucus hypersecretion, and airway remodeling associated with COPD. Learn More
|
A10217 |
Cilostazol |
Cilostazol is a selective inhibitor of 3-type phosphodiesterase (PDE3) with therapeutic focus on cAMP. Learn More
|
A13722 |
Deltarasin HCl |
Deltarasin is a novel small molecule inhibiting the KRAS PDEδ interaction and thus impairing oncogenic KRAS signalling.
Learn More
|
A11073 |
GSK256066 |
GSK256066 is an exceptionally high affinity and selective inhibitor of PDE4 that inhibits PDE4 isoforms A-D with equal affinity and has a high HARBS (High-Affinity Rolipram Binding Site) ratio (>17). Learn More
|
A15097 |
GSK256066 2,2,2-trifluoroacetic acid |
GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380,000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7. Learn More
|
A10449 |
Hesperetin |
Hesperetin, a selective phosphodiesterase (PDE)4 inhibitor, is present in the traditional Chinese medicine, “Chen Pi.” Hesperetin is a citrus flavonoid that has been reported to lower plasma cholesterol. Hesperetin reduces the transcription of ACAT-2 mRNA in Hep-G2 cells and reduces ApoB protein synthesis in a dose-dependent manner. It also is a potential therapy for carcinoid cancer. Learn More
|
A11019 |
Ibudilast (KC-404) |
Ibudilast, a pharmacologic phosphodiesterase inhibitor, prevents human immunodeficiency Virus-1 Tat-Mediated activation of microglial cells. Learn More
|
A10464 |
Icariin |
Icariin is inhibitory to all three PDE5 isoforms that inhibits PDE5A1, A2, and A3 with an IC50 value of 1.0, 0.75, and 1.1 microM, respectively. Learn More
|
A10541 |
Luteolin |
Luteolin is a PDE4 inhibitor, phosphodiesterase inhibitor, and an interleukin 6 inhibitor, affecting xylazine/ketamine-induced anesthesia in mice. Luteolin acts as a monoamine transporter activator, and is one of the few chemicals demonstrated to possess this property. Learn More
|
A10592 |
Milrinone (Primacor) |
Milrinone(Primacor) is a a potent and selective phosphodiesterase 3 inhibitor with an IC50 of 0.42 μM for the inhibition of FIII PDE
Learn More
|
A15198 |
Olprinone Hydrochloride |
Olprinone is a selective phosphodiesterase 3 (PDE3) inhibitor. Learn More
|
A13121 |
PF-04447943 |
PF-04447943 is a potent, selective brain penetrant PDE9 inhibitor that increased indicators of hippocampal synaptic plasticity and improved cognitive function in a variety of cognition models in both rats and mice. Learn More
|
A11191 |
PF-2545920 |
PF-2545920 is a phosphodiesterase inhibitor selective for the PDE10A subtype. Learn More |
A10733 |
Pimobendan (Vetmedin) |
Pimobendan (Vetmedin) is a calcium sensitizer with positive inotropic and vasodilator effects. It is also a selective inhibitor of phosphodiesterase III (PDE3). Learn More
|
A10804 |
Roflumilast |
Roflumilast acts as a selective, long-acting inhibitor of the enzyme PDE-4. Learn More
|
A15799 |
TAK-063 |
TAK-063 is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM; >15000-fold selectivity over other PDEs. Learn More
|
A12550 |
Zardaverine |
Zardaverine is a phosphodiesterase inhibitor, selective for PDE3 and 4 (IC50 values are 0.5 and 0.8 ??M respectively). Learn More
|
25 Item(s)
per page
Phosphodiesterases (PDEs)
Minimal Price: $32.00