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Phosphodiesterases (PDEs)
| Catalog No. | Product Name | Application | Product Information |
|---|---|---|---|
A12776 SALE |
AN2728 |
PDE4 inhibitor |
AN2728 is a topically administered, boron-containing, anti-inflammatory compound that inhibits PDE4 activity and thereby suppresses the release of TNFalpha, IL-12, IL-23 and other cytokines
|
A11289 SALE |
Apremilast (CC 10004) |
PDE4 Inhibitor |
Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis.
|
A12619 |
Avanafil |
PDE5 inhibitor |
Avanafil is a PDE5 Inhibitor for the Treatment of Erectile Dysfunction
|
A11326 |
Bay 60-7550 |
PDE-2 Inhibitor |
BAY 60-7550 is a potent PDE2 inhibitor with IC50 values of 2.0 nM (bovine) and 4.7 nM (human).
|
A10216 |
Cilomilast (SB-207499) |
PDE-4 inhibitor |
Cilomilast is orally active and acts as a selective Phosphodiesterase-4 inhibitor with antiinflammatory effects that target bronchoconstriction, mucus hypersecretion, and airway remodeling associated with COPD.
|
A13596 |
Cilostamide |
PDE3 inhibitor |
Cilostamide is a selective inhibitor of phosphodiesterase (PDE)3A and PDE3B with IC50 values of 27 and 50 nM, respectively.
|
A10217 |
Cilostazol |
PDE3 inhibitor |
Cilostazol is a selective inhibitor of 3-type phosphodiesterase (PDE3) with therapeutic focus on cAMP.
|
A13722 SALE |
Deltarasin HCl |
PDE-KRAS inhibitor |
Deltarasin is a novel small molecule inhibiting the KRAS PDEδ interaction and thus impairing oncogenic KRAS signalling.
|
A11073 |
GSK256066 |
PDE Inhibitor |
GSK256066 is an exceptionally high affinity and selective inhibitor of PDE4 that inhibits PDE4 isoforms A-D with equal affinity and has a high HARBS (High-Affinity Rolipram Binding Site) ratio (>17).
|
A15097 |
GSK256066 2,2,2-trifluoroacetic acid |
PDE Inhibitor |
GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380,000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7.
|
A10449 SALE |
Hesperetin |
PDE4 inhibitor |
Hesperetin, a selective phosphodiesterase (PDE)4 inhibitor, is present in the traditional Chinese medicine, “Chen Pi.” Hesperetin is a citrus flavonoid that has been reported to lower plasma cholesterol. Hesperetin reduces the transcription of ACAT-2 mRNA in Hep-G2 cells and reduces ApoB protein synthesis in a dose-dependent manner. It also is a potential therapy for carcinoid cancer.
|
A11019 SALE |
Ibudilast (KC-404) |
PDE Inhibitor |
Ibudilast, a pharmacologic phosphodiesterase inhibitor, prevents human immunodeficiency Virus-1 Tat-Mediated activation of microglial cells.
|
A10464 SALE |
Icariin |
PDE5 inhibitor |
Icariin is inhibitory to all three PDE5 isoforms that inhibits PDE5A1, A2, and A3 with an IC50 value of 1.0, 0.75, and 1.1 microM, respectively.
|
A10541 SALE |
Luteolin |
PDE4 inhibitor |
Luteolin is a PDE4 inhibitor, phosphodiesterase inhibitor, and an interleukin 6 inhibitor, affecting xylazine/ketamine-induced anesthesia in mice. Luteolin acts as a monoamine transporter activator, and is one of the few chemicals demonstrated to possess this property.
|
A10592 SALE |
Milrinone (Primacor) |
PDE3 inhibitor |
Milrinone(Primacor) is a a potent and selective phosphodiesterase 3 inhibitor with an IC50 of 0.42 μM for the inhibition of FIII PDE
|
A13467 |
MK-0359 |
PDE4 inhibitor |
MK-0359 is a selective and potent oral PDE4 inhibitor, in chronic asthma.
|
A15191 |
Nortadalafil |
PDE5 inhibitor |
Nortadalafil is demethyl Tadalafil, which is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) under the name Cialis; and under the name Adcirca for the treatment of pulmonary arterial hypertension.
|
A15197 |
Oglemilast |
PDE4 inhibitor |
Oglemilast is a potent inhibitor of PDE4.
|
A15198 |
Olprinone Hydrochloride |
PDE3 inhibitor |
Olprinone is a selective phosphodiesterase 3 (PDE3) inhibitor.
|
A13121 |
PF-04447943 |
PDE9 inhibitor |
PF-04447943 is a potent, selective brain penetrant PDE9 inhibitor that increased indicators of hippocampal synaptic plasticity and improved cognitive function in a variety of cognition models in both rats and mice.
|
A11191 SALE |
PF-2545920 |
PDE10A inhibitor |
PF-2545920 is a phosphodiesterase inhibitor selective for the PDE10A subtype. |
A10733 |
Pimobendan (Vetmedin) |
PDE inhibitor |
Pimobendan (Vetmedin) is a calcium sensitizer with positive inotropic and vasodilator effects. It is also a selective inhibitor of phosphodiesterase III (PDE3).
|
A10804 SALE |
Roflumilast |
PDE inhibitor |
Roflumilast acts as a selective, long-acting inhibitor of the enzyme PDE-4.
|
A10805 SALE |
Rolipram |
PDE4 inhibitor |
Rolipram is a PDE4-inhibitor with IC50 = 2.0 μM.
|
A12631 |
Sildenafil |
PDE5 inhibitor |
Sildenafil, one of the selective phosphodiesterase-5 (PDE5) inhibitors(IC50= 5.22 nM), is considered the best treatment for erectile dysfunction.
|
