ROCK

Inhibitory Selectivity
Catalog No.Inhibitor Name ROCKROCK1ROCK2Other
A11001Y-27632 2HCl
*
*
A10928Thiazovivin
*
A10381Fasudil HCl
*
PKA,PKG,PKC
A10441GSK429286A
***
**
A13067RKI-1447
***
***
A12348GSK269962
****
****
MSK1,RSK1
A15888Ripasudil
**
**
A15239KD025
**
A12464AT13148
***
****
PKA,p70S6K,Akt1

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A11001 SALE

Y-27632 2HCl

ROCK Inhibitor
Y-27632 is a Rho-Associated Coil Kinase (ROCK) inhibitor that increases the cloning efficiency of human embryonic stem cells (hESCs).
A10928 SALE

Thiazovivin

ROCK inhibitor
Thiazovivin is a selective inhibitor of Rho-associated kinase (ROCK).
A10441 SALE

GSK429286A

ROCK Inhibitor
GSK429286A is a cell-permeable, selective small molecule inhibitor of Rho-associated, coiled-coil containing protein kinase (ROCK).
A12348

GSK 269962

ROCK inhibotor
GSK 269962 is a potent Rho kinase (ROCK) inhibitor (IC50 values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively).
A10381 SALE

Fasudil HCl (HA-1077)

ROCK inhibitor
Fasudil HCl is a cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 μM).
A13785

HA-1077 dihydrochloride

ROCK Inhibitor
HA-1077 inhibits vascular smooth muscle contraction by acting as an intracellular Ca2+ antagonist.
A11610

Y-33075

ROCK inhibitor
Y-33075 is ROCK (Rho-associated coiled coil-forming protein kinase) inhibitor.
A13067 SALE

RKI-1447

ROCK1/ROCK2 inhibitor
RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer.
A12464

AT13148

multi-AGC kinase inhibitor
AT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors.
A15045

chroman 1

ROCK Inhibitor
Chroman 1 is a highly potent and selective ROCK II inhibitor.
A15101 SALE

H-1152

ROCK inhibitor
H-1152, an isoquinolinesulfonamide derivative, is a more specific, stronger and membrane-permeable inhibitor of Rho-kinase with a Ki value of 1.6 nM, but poor inhibitor of other serine/threonine kinases.
A13659

Glycyl-H 1152 2HCl

ROCK inhibitor
Glycyl-H 1152 2HCl is a selective and potent ROCK inhibitor (IC50 values are 0.0118, 2.35, 2.57, 3.26, > 10 and >10 uM for ROCKII, Aurora A, CAMKII, PKG, PKA and PKC respectively.)
A15102

H-1152 dihydrochloride

ROCK inhibitor
H-1152 dihydrochloride, an isoquinolinesulfonamide derivative, is a more specific, stronger and membrane-permeable inhibitor of Rho-kinase with a Ki value of 1.6 nM, but poor inhibitor of other serine/threonine kinases.
A15239

SLx-2119 (KD025)

ROCK2 Inhibitor
SLx-2119 is a small molecule and selective inhibitor of ROCK2 with IC50 of 105 nM; > 200 fold selecivity over ROCK1(IC50 =24 uM).
A15921 SALE

SAR407899 HCl

ROCK inhibitor
SAR407899 is a potent and selective Rho kinase inhibitor with promising antihypertensive activity.
A15888

Ripasudil

ROCK inhibitor
Ripasudil (K-115) is potent ROCK inhibitor with IC50 of 51 nM and 19 nM for ROCK1 and ROCK2, respectively, used for the treatment of glaucoma and ocular hypertension.
A16211

LX7101

LIMK2 inhibitor
LX7101 is a pyrrolopyrimidine-based, topically-delivered inhibitor of LIM domain kinase 2 (LIMK2), a kinase associated with the regulation of intraocular pressure.
A15226

ROCK inhibitor-1

ROCK inhibitor
N/A
A15225

ROCK inhibitor

ROCK inhibitor
ROCK inhibitor is a highly potent inhibitor of human ROCK-1 and ROCK-2 isoenzymes with IC50 values of 0.6 and 1.1 nM, respectively.
A15178

Narciclasine

ROCK activator
Narciclasine is a Rho/Rho kinase/LIM kinase/cofilin signaling pathway activator.
A15118 SALE

Hydroxyfasudil

ROCK inhibitor
Hydroxyfasudil, metabolite of Fasudil, is a potent Rho-kinase inhibitor and vasodilator.
A15119

Hydroxyfasudil hydrochloride

ROCK inhibitor
Hydroxyfasudil hydrochloride, metabolite of Fasudil, is a potent Rho-kinase inhibitor and vasodilator.
A12674

SR 3677 dihydrochloride

ROCK inhibitor
SR 3677 dihydrochloride is a potent and selective Rho-kinase inhibitor (IC50 values are 3 and 56 nM for ROCK-II and ROCK-I respectively).

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