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$0.00 ATM / ATR
| Catalog No. | Inhibitor Name | ATM | ATR | Other Targets |
|---|---|---|---|---|
| A10133 | Dactolisib | *** | p110α,p110γ,mTOR (p70S6K) | |
| A10506 | KU-55933 | **** | DNA-PK,mTOR,PI3K | |
| A10507 | KU-60019 | **** | ||
| A11605 | VE-821 | *** | ||
| A11161 | Wortmannin | ** | * | PI3K,DNA-PK,MLCK |
| A11586 | Torin 2 | *** | ** | mTOR,DNA-PK |
| A11086 | CP-466722 | ** | ||
| A13289 | VE-822 | * | *** | |
| A13328 | ETP-46464 | * | *** | mTOR,DNA-PK,PI3Kα |
| A13191 | CGK 733 | ** | ** | |
| A13205 | AZ20 | **** | mTOR | |
| A15794 | AZD6738 | **** | ||
| A11991 | Schisandrin B | * |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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KU-55933
Catalog No. A10506 ATM inhibitorKU-55933 is an ATM inhibitor by suppressing cell proliferation and induces apoptosis by blocking Akt in cancer cells with overactivated Akt. Learn More -
ATR inhibitor 2
Catalog No. A22162 ATR inhibitorATR inhibitor 2 is an ATP-competitive, orally active, and selective ATR inhibitor, with a Ki of <150 pM. Learn More -
ATM Inhibitor-1
Catalog No. A19931 ATM inhibitorATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibitor, with an IC50 of 0.7 nM. Learn More -
ATR inhibitor 1
Catalog No. A19874 ATR inhibitorATR inhibitor 1 is a ATR inhibitor extracted from patent WO2015187451A1, compound I-l, has a Ki value below 1 ?μ. Learn More -
BAY-1895344
Catalog No. A19454 ATR inhibitorBAY-1895344 is a potent, orally available and selective ATR inhibitor, with IC50 of 7 nM. Anti-tumor activity. Learn More -
Chloroquine Phosphate
Catalog No. A16445 Chloroquine phosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator. Learn More -
AZD0156
Catalog No. A16419 ATM inhibitorAZD0156 is a potent and selective inhibitors of ATM kinase, with potential chemo-/radio-sensitizing and antineoplastic activities. Learn More -
Mirin
Catalog No. A15842 ATM InhibitorMirin prevents ATM activation in response to double strand breaks (IC50 = 12 uM) and induces G2 cell cycle arrest. Learn More -
AZD6738 (Ceralasertib)
Catalog No. A15794 ATR inhibitorAZD6738 is a potent inhibitor of ATR kinase activity with an IC50 of 1 nM against the isolated enzyme and 74 nM against ATR kinase-dependent CHK1 phosphorylation in cells. Learn More -
VE-822
Catalog No. A13289 -
ETP-46464
Catalog No. A13328 ATR inhibitorETP-46464 is a potent and selective inhibitor of ATR with IC50 of 25 nM. Learn More -
AZ-20
Catalog No. A13205 ATR kinase inhibitorAZ20 is a potent and selective inhibitor of ATR with an IC50 value of 5 nM. Learn More -
CGK 733
Catalog No. A13191 ATM/ATR inhibitorCGK733 is a selective inhibitor of ATR and ATM kinases. Induces cell death in prematurely senescent breast cancer cells. Learn More -
Torin 2
Catalog No. A11586 mTOR inhibitorTorin 2 is a potent and selective mTOR inhibitor (IC50 = 2.1 nM). Displays 800-fold cellular selectivity for mTOR over PI3K (cellular EC50 values are 0.25 and 200 nM for mTOR and PI3K respectively). Learn More -
Schisandrin B
Catalog No. A11991 Schisandrin B is the most abundant dibenzocyclooctadiene isolated from the fruit of Schisandra chinensis (Turcz) Baillon or Wu-Wei-Zi (transliterally meaning "the fruit of five tastes" in Chinese), which is a commonly used tonic herb in Chinese medicine, particularly for the treatment of liver ailments. Learn More -
VE-821
Catalog No. A11605 ATM/ATR inhibitorVE-821 is a potent and selective inhibitor of protein kinase ATR. Learn More -
KU-60019
Catalog No. A10507 ATM InhibitorKU-60019 is a potent and specific ATM inhibitor with IC50 of 6.3 nM. Learn More -
Wortmannin
Catalog No. A11161 PI3K inhibitorWortmannin is a potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC50 = 2 - 4 nM) which also potently inhibits polo-like kinase 1 (PLK1) (IC50 = 5.8 nM).
Learn More -
CP-466722
Catalog No. A11086 ATM inhibitorCP-466722 is a specific ATM inhibitor that inhibits cellular ATM-dependent phosphorylation events and disruption of ATM function resulted in characteristic cell cycle checkpoint defects. Learn More -
BEZ235 (NVP-BEZ235, Dactolisib)
Catalog No. A10133 PI3K/mTOR InhibitorBEZ235 (NVP-BEZ235) inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. Learn More -
NU6027
Catalog No. A14136 ATR/CDK inhibitorNU6027 is a potent inhibitor of cellular ATR activity (IC(50)=6.7 μM) and enhanced hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner. Learn More -
AZ32
Catalog No. A16814 ATM inhibitorAZ32 is a specific inhibitor of the ATM kinase that possesses good BBB penetration in mouse with an IC50 value of <0.0062 μM for ATM enzyme. It shows adequate selectivity over ATR and also has high cell permeability. Learn More -
AZ31
Catalog No. A16813 ATM inhibitorAZ31 is a selective and novel ATM inhibitor with an IC50 of <0.0012 μM. It shows excellent selectivity over closely related enzymes (>500 fold selective over DNA-PK and PI3Kα and >1000 fold selective over mTOR, PI3Kβ and PI3Kγ). Learn More -
AZD1390
Catalog No. A16798 ATM inhibitorAZD1390 is a first-in-class orally available and CNS penetrant ATM inhibitor with an IC50 of 0.78 nM in cells and >10,000-fold selectivity over closely related members of the PIKK family of enzymes and excellent selectivity across a broad panel of kinases. Learn More -
KU 59403
Catalog No. A20928
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