Dehydrogenases

Catalog No.Inhibitor Name Dehydrogenase
A10613Mycophenolate Mofetil
***
A12902AGI-5198
**
A11403MK-8245
****
A15892NCT-501
**
A15798SW033291
****
A12997Vidofludimus
*
A12903AGI-6780
***
A11786CPI-613
A10521Leflunomide
A10320Disulfiram
A10949Trilostane
A12899PluriSIn #1 (NSC 14613)
A10070Ammonium Glycyrrhizinate
A11682Gimeracil
A14795Gossypol Acetate
A10353Enoxolone
A10348Emodin

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

29 Item(s)

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  1. AG-120 (Ivosidenib)

    Catalog No. A14386
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    IDH1 inhibitor
    AG-120 is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Learn More
  2. Enasidenib

    Catalog No. A15808
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    IDH2 inhibitor
    Enasidenib is a potent and selective IDH2 inhibitor with potential anticancer activity (IDH2 = Isocitrate dehydrogenase 2). Learn More
  3. Ammonium Glycyrrhizinate (AMGZ)

    Catalog No. A10070
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    Dehydrogenase inhibitor
    Mono-ammonium glycyrrhizinate(AMGZ) is a unique product derived from Licorice root and has an extremely sweet taste. Learn More
  4. Vidofludimus (4SC-101)

    Catalog No. A12997
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    DHODH inhibitor
    Vidofludimus is a novel orally active and potent DHODH inhibitor. Learn More
  5. AZD4017

    Catalog No. A13542
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    HSD1 inhibitor
    AZD4017 is a potent, selective, and orally bioavailable11b-HSD1 inhibitor (11b-hydroxysteroid dehydrogenase type 1 inhibitor). Learn More
  6. Monoammoniumglycyrrhizinate

    Catalog No. A14599
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    Monoammoniumglycyrrhizinate is a constituent of the licorice root that has vital anti-viral activities that have been shown to inhibit the expression of 11_?HSD2 (11_?hydroxysteroid dehydrogenase type 2) via an indirect mechanism. Learn More
  7. MK-8245 Trifluoroacetate

    Catalog No. A15170
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    Liver-targeting SCD Inhibitor‎
    MK-8245 trifluoroacetate is a liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy. Learn More
  8. SW033291

    Catalog No. A15798
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    15-PGDH enzyme inhibitor
    SW033291 is a small-molecule inhibitor of 15-PGDH (Ki=0.1 nM) that increases prostaglandin PGE2 levels in bone marrow and other tissues. Learn More
  9. Alda 1

    Catalog No. A15805
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    ALDH2 Activator
    Alda 1 is an activator of aldehyde dehydrogenase 2 (ALDH2). Learn More
  10. NCT-501

    Catalog No. A15892
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    hALDH1 Inhibitor‎
    NCT-501 is a potent and selective inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1) with IC50 of 40 nM. Learn More
  11. AG-120

    Catalog No. A15869
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    Dehydrogenase Inhibitor
    AG-120 is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Learn More
  12. Trilostane

    Catalog No. A10949
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    Trilostane is an inhibitor of 3??-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome. Learn More
  13. Fomepizole

    Catalog No. A16164
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    alcohol dehydrogenase inhibitor
    Fomepizole is an alcohol dehydrogenase inhibitor used for the treatment of ethylene glycol and methanol poisonings in adults. Learn More
  14. ASP9521

    Catalog No. A14412
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    ASP9521 is a novel, selective, orally bioavailable inhibitor of 17??-hydroxysteroid dehydrogenase type 5 (17bHSD5, AKR1C3). Learn More
  15. AGI-6780

    Catalog No. A12903
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    IDH2 R140Q inhibitor
    AGI-6780 is a potent, selective inhibitor of mutant IDH2 with an IC50 value of 23 nM. Learn More
  16. AGI-5198 (IDH-C35)

    Catalog No. A12902
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    IDH1 inhibitor
    AGI-5198, also know as IDH-C35, is the a very potent and selective mutant IDH1 inhibitor that was shown to potential anticancer activity. Learn More
  17. Glycyrrhetinic acid (Enoxolone)

    Catalog No. A10353
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    15-PGDH inhibitor
    Glycyrrhetinic acid inhibits the enzymes (15-hydroxyprostaglandin dehydrogenase and delta-13-prostaglandin) that metabolize the prostaglandins PGE-2 and PGF-2α to their respective 15-keto-13,14-dihydro metabolites which are inactive. Learn More
  18. MK-8245

    Catalog No. A11403
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    SCD inhibitor
    MK-8245 is a Liver-Targeted Stearoyl-CoA Desaturase (SCD) Inhibitor. MK-8245 is useful for the Treatment of Diabetes and Dyslipidemia. Learn More
  19. Celastrol

    Catalog No. A10192
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    Celastrol is a triterpenoid antioxidant compound isolated from the Chinese Thunder of God vine (T. wilfordii). In an isolated rat liver assay of lipid peroxidation, celastrol had an IC50 value of 7 µM, equivalent to about 15 times the antioxidant potency of α-tocopherol.

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  20. Mycophenolate mofetil (CellCept)

    Catalog No. A10613
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    IMPDH inhibitor
    Mycophenolate mofetil is a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH) in purine biosynthesis (specifically guanine synthesis) which is necessary for the growth of T cells and B cells. Learn More
  21. Gossypol

    Catalog No. A10435
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    Gossypol is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. Learn More
  22. Leflunomide

    Catalog No. A10521
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    Dehydrogenase inhibitor
    Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs. Leflunomide is used to relieve symptoms caused by rheumatoid arthritis, such as inflammation, swelling, stiffness, and joint pain. Learn More
  23. Gimeracil

    Catalog No. A11682
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    Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase, inhibits the early step in homologous recombination. Learn More
  24. CPI-613

    Catalog No. A11786
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    Dehydrogenase Inhibitor
    CPI-613 is a racemic mixture of the enantiomers of a synthetic alpha-lipoic lipoic acid analogue with potential chemopreventive and antineoplastic activities. Learn More
  25. Ranolazine

    Catalog No. A10780
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    Ranolazine is a partial fatty acid oxidation inhibitor, shifts ATP production from fatty acid to more oxygen-efficient carbohydrate oxidation. Learn More
  26. Disulfiram

    Catalog No. A10320
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    Disulfiram blocks the processing of alcohol in the body by inhibiting acetaldehyde dehydrogenase thus causing an unpleasant reaction when alcohol is consumed. Learn More
  27. Brequinar

    Catalog No. A12442
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    Dihydroorotate Dehydrogenase Inhibitor
    Brequinar is an inhibitor of dihydroorotate dehydrogenase, an enzyme that is required for de novo pyrimidine biosynthesis. Learn More
  28. CGP 3466B maleate

    Catalog No. A12385
    GAPDH inhibitor
    CGP 3466B maleate is an orally active glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor. Learn More
  29. CBR 5884

    Catalog No. A16176
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    PHGDH inhibitor
    CBR 5884 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells with an IC50 value of 33 uM. Learn More

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